Oocyte-associated transcription factors in reprogramming after somatic cell nuclear transfer: a review
Oocytes are unique cells with the inherent capability to reprogram nuclei. The reprogramming of the somatic nucleus from its original cellular state to a totipotent state is essential for term development after somatic cell nuclear transfer. The nuclear-associated factors contained within oocytes ar...
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| Format: | Article |
| Language: | English |
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Higher Education Press
2014-06-01
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| Series: | Frontiers of Agricultural Science and Engineering |
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| Online Access: | http://academic.hep.com.cn/fase/fileup/2095-7505/PDF/2095-7505-2014-2-104.pdf |
| _version_ | 1818694609077796864 |
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| author | Fengxia YIN,Hui LIU,Shorgan BOU,Guangpeng LI |
| author_facet | Fengxia YIN,Hui LIU,Shorgan BOU,Guangpeng LI |
| author_sort | Fengxia YIN,Hui LIU,Shorgan BOU,Guangpeng LI |
| collection | DOAJ |
| description | Oocytes are unique cells with the inherent capability to reprogram nuclei. The reprogramming of the somatic nucleus from its original cellular state to a totipotent state is essential for term development after somatic cell nuclear transfer. The nuclear-associated factors contained within oocytes are critical for normal fertilization by sperm or for somatic cell nuclear reprogramming. The chromatin of somatic nuclei can be reprogrammed by factors in the egg cytoplasm whose natural function is to reprogram sperm chromatin. The oocyte first obtains its reprogramming capability in the early fetal follicle, and then its capacity is enriched in the late growth phase and reaches its highest capability for reprogramming as fully-grown germinal vesicle oocytes. The cytoplasmic milieu most likely contains all of the specific transcription and/or reprogramming factors necessary for cellular reprogramming. Certain transcription factors in the cytoplast may be critical as has been demonstrated for induced pluripotent stem cells. The maternal pronucleus exerts a predominant, transcription-dependent effect on embryo cytofragmentation, with a lesser effect imposed by the ooplasm and the paternal pronucleus. With deep analysis of transcriptomics in oocytes and early developmental stage embryos more maternal transcription factors inducing cellular reprogramming will be identified. |
| first_indexed | 2024-12-17T13:32:18Z |
| format | Article |
| id | doaj.art-ddd0a521fcb94f628fc8a615e4477a79 |
| institution | Directory Open Access Journal |
| issn | 2095-7505 |
| language | English |
| last_indexed | 2024-12-17T13:32:18Z |
| publishDate | 2014-06-01 |
| publisher | Higher Education Press |
| record_format | Article |
| series | Frontiers of Agricultural Science and Engineering |
| spelling | doaj.art-ddd0a521fcb94f628fc8a615e4477a792022-12-21T21:46:32ZengHigher Education PressFrontiers of Agricultural Science and Engineering2095-75052014-06-011210411310.15302/J-FASE-2014003Oocyte-associated transcription factors in reprogramming after somatic cell nuclear transfer: a reviewFengxia YIN,Hui LIU,Shorgan BOU,Guangpeng LI0The Key Laboratory of National Education Ministry for Mammalian Reproductive Biology and Biotechnology, Inner Mongolia University, Hohhot 010070, ChinaOocytes are unique cells with the inherent capability to reprogram nuclei. The reprogramming of the somatic nucleus from its original cellular state to a totipotent state is essential for term development after somatic cell nuclear transfer. The nuclear-associated factors contained within oocytes are critical for normal fertilization by sperm or for somatic cell nuclear reprogramming. The chromatin of somatic nuclei can be reprogrammed by factors in the egg cytoplasm whose natural function is to reprogram sperm chromatin. The oocyte first obtains its reprogramming capability in the early fetal follicle, and then its capacity is enriched in the late growth phase and reaches its highest capability for reprogramming as fully-grown germinal vesicle oocytes. The cytoplasmic milieu most likely contains all of the specific transcription and/or reprogramming factors necessary for cellular reprogramming. Certain transcription factors in the cytoplast may be critical as has been demonstrated for induced pluripotent stem cells. The maternal pronucleus exerts a predominant, transcription-dependent effect on embryo cytofragmentation, with a lesser effect imposed by the ooplasm and the paternal pronucleus. With deep analysis of transcriptomics in oocytes and early developmental stage embryos more maternal transcription factors inducing cellular reprogramming will be identified.http://academic.hep.com.cn/fase/fileup/2095-7505/PDF/2095-7505-2014-2-104.pdfnuclear reprogramming|somatic cell|transcription factors|transcriptomics |
| spellingShingle | Fengxia YIN,Hui LIU,Shorgan BOU,Guangpeng LI Oocyte-associated transcription factors in reprogramming after somatic cell nuclear transfer: a review Frontiers of Agricultural Science and Engineering nuclear reprogramming|somatic cell|transcription factors|transcriptomics |
| title | Oocyte-associated transcription factors in reprogramming after somatic cell nuclear transfer: a review |
| title_full | Oocyte-associated transcription factors in reprogramming after somatic cell nuclear transfer: a review |
| title_fullStr | Oocyte-associated transcription factors in reprogramming after somatic cell nuclear transfer: a review |
| title_full_unstemmed | Oocyte-associated transcription factors in reprogramming after somatic cell nuclear transfer: a review |
| title_short | Oocyte-associated transcription factors in reprogramming after somatic cell nuclear transfer: a review |
| title_sort | oocyte associated transcription factors in reprogramming after somatic cell nuclear transfer a review |
| topic | nuclear reprogramming|somatic cell|transcription factors|transcriptomics |
| url | http://academic.hep.com.cn/fase/fileup/2095-7505/PDF/2095-7505-2014-2-104.pdf |
| work_keys_str_mv | AT fengxiayinhuiliushorganbouguangpengli oocyteassociatedtranscriptionfactorsinreprogrammingaftersomaticcellnucleartransferareview |