Knockdown of SHMT2 enhances the sensitivity of gastric cancer cells to radiotherapy through the Wnt/β-catenin pathway
Gastric cancer (GC) is one of the most common malignant tumors. The mechanism of GC radioresistance and new radiosensitizers must be revealed and developed to treat GC. Serine hydroxymethyltransferase 2 (SHMT2) is responsible for encoding the mitochondrial form of the pyridoxal phosphate-dependent e...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2022-09-01
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| Series: | Open Life Sciences |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/biol-2022-0480 |
| _version_ | 1818027530901258240 |
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| author | Mao Yu Zhang Tiyong |
| author_facet | Mao Yu Zhang Tiyong |
| author_sort | Mao Yu |
| collection | DOAJ |
| description | Gastric cancer (GC) is one of the most common malignant tumors. The mechanism of GC radioresistance and new radiosensitizers must be revealed and developed to treat GC. Serine hydroxymethyltransferase 2 (SHMT2) is responsible for encoding the mitochondrial form of the pyridoxal phosphate-dependent enzyme. SHMT2 plays a critical role in several types of cancers, while its possible effect on the radiological resistance in GC is still unclear. In this study, we investigated the role of SHMT2 in the radiological resistance of GC. Our data confirmed that SHMT2 was highly expressed in radiation-resistant GC cells. SHMT2 reduced the radiosensitivity of GC cells. In addition, SHMT2 is involved in radiation-induced GC cell apoptosis. Further, SHMT2 regulated the Wnt/β-catenin pathway, therefore reducing the radiosensitivity of GC cells in vivo. In conclusion, we revealed that depletion of SHMT2 enhanced the sensitivity of GC cells to interventional radiotherapy through the Wnt/β-catenin pathway. |
| first_indexed | 2024-12-10T04:49:22Z |
| format | Article |
| id | doaj.art-ddd0fe50da304c6793f045b78ab10703 |
| institution | Directory Open Access Journal |
| issn | 2391-5412 |
| language | English |
| last_indexed | 2024-12-10T04:49:22Z |
| publishDate | 2022-09-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Life Sciences |
| spelling | doaj.art-ddd0fe50da304c6793f045b78ab107032022-12-22T02:01:39ZengDe GruyterOpen Life Sciences2391-54122022-09-011711249125510.1515/biol-2022-0480Knockdown of SHMT2 enhances the sensitivity of gastric cancer cells to radiotherapy through the Wnt/β-catenin pathwayMao Yu0Zhang Tiyong1Department of General Surgery Unit 1, Yuhuan People’s Hospital, Taizhou, Zhejiang Province, 317699, ChinaDepartment of Radiology, Qianjiang Central Hospital of Chongqing Municipality, No. 63, West Ninth Road, Qianjiang District City, Chongqing, 409000, ChinaGastric cancer (GC) is one of the most common malignant tumors. The mechanism of GC radioresistance and new radiosensitizers must be revealed and developed to treat GC. Serine hydroxymethyltransferase 2 (SHMT2) is responsible for encoding the mitochondrial form of the pyridoxal phosphate-dependent enzyme. SHMT2 plays a critical role in several types of cancers, while its possible effect on the radiological resistance in GC is still unclear. In this study, we investigated the role of SHMT2 in the radiological resistance of GC. Our data confirmed that SHMT2 was highly expressed in radiation-resistant GC cells. SHMT2 reduced the radiosensitivity of GC cells. In addition, SHMT2 is involved in radiation-induced GC cell apoptosis. Further, SHMT2 regulated the Wnt/β-catenin pathway, therefore reducing the radiosensitivity of GC cells in vivo. In conclusion, we revealed that depletion of SHMT2 enhanced the sensitivity of GC cells to interventional radiotherapy through the Wnt/β-catenin pathway.https://doi.org/10.1515/biol-2022-0480gastric cancershmt2apoptosisradiosensitivitywnt/β-catenin pathway |
| spellingShingle | Mao Yu Zhang Tiyong Knockdown of SHMT2 enhances the sensitivity of gastric cancer cells to radiotherapy through the Wnt/β-catenin pathway Open Life Sciences gastric cancer shmt2 apoptosis radiosensitivity wnt/β-catenin pathway |
| title | Knockdown of SHMT2 enhances the sensitivity of gastric cancer cells to radiotherapy through the Wnt/β-catenin pathway |
| title_full | Knockdown of SHMT2 enhances the sensitivity of gastric cancer cells to radiotherapy through the Wnt/β-catenin pathway |
| title_fullStr | Knockdown of SHMT2 enhances the sensitivity of gastric cancer cells to radiotherapy through the Wnt/β-catenin pathway |
| title_full_unstemmed | Knockdown of SHMT2 enhances the sensitivity of gastric cancer cells to radiotherapy through the Wnt/β-catenin pathway |
| title_short | Knockdown of SHMT2 enhances the sensitivity of gastric cancer cells to radiotherapy through the Wnt/β-catenin pathway |
| title_sort | knockdown of shmt2 enhances the sensitivity of gastric cancer cells to radiotherapy through the wnt β catenin pathway |
| topic | gastric cancer shmt2 apoptosis radiosensitivity wnt/β-catenin pathway |
| url | https://doi.org/10.1515/biol-2022-0480 |
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