Paracoccidioidomycosis Diagnosed in Europe—A Systematic Literature Review
Paracoccidioidomycosis is a systemic mycosis that is endemic in geographical regions of Central and South America. Cases that occur in nonendemic regions of the world are imported through migration and travel. Due to the limited number of cases in Europe, most physicians are not familiar with paraco...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Journal of Fungi |
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| Online Access: | https://www.mdpi.com/2309-608X/7/2/157 |
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| author | Gernot Wagner Deddo Moertl Anna Glechner Verena Mayr Irma Klerings Casey Zachariah Miriam Van den Nest Gerald Gartlehner Birgit Willinger |
| author_facet | Gernot Wagner Deddo Moertl Anna Glechner Verena Mayr Irma Klerings Casey Zachariah Miriam Van den Nest Gerald Gartlehner Birgit Willinger |
| author_sort | Gernot Wagner |
| collection | DOAJ |
| description | Paracoccidioidomycosis is a systemic mycosis that is endemic in geographical regions of Central and South America. Cases that occur in nonendemic regions of the world are imported through migration and travel. Due to the limited number of cases in Europe, most physicians are not familiar with paracoccidioidomycosis and its close clinical and histopathological resemblance to other infectious and noninfectious disease. To increase awareness of this insidious mycosis, we conducted a systematic review to summarize the evidence on cases diagnosed and reported in Europe. We searched PubMed and Embase to identify cases of paracoccidioidomycosis diagnosed in European countries. In addition, we used Scopus for citation tracking and manually screened bibliographies of relevant articles. We conducted dual abstract and full-text screening of references yielded by our searches. To identify publications published prior to 1985, we used the previously published review by Ajello et al. Overall, we identified 83 cases of paracoccidioidomycosis diagnosed in 11 European countries, published in 68 articles. Age of patients ranged from 24 to 77 years; the majority were male. Time from leaving the endemic region and first occurrence of symptoms considerably varied. Our review illustrates the challenges of considering systemic mycosis in the differential diagnosis of people returning or immigrating to Europe from endemic areas. Travel history is important for diagnostic-workup, though it might be difficult to obtain due to possible long latency period of the disease. |
| first_indexed | 2024-03-09T00:36:56Z |
| format | Article |
| id | doaj.art-ddd1aaa3ea1240f1a3d93ff4e4d34e6b |
| institution | Directory Open Access Journal |
| issn | 2309-608X |
| language | English |
| last_indexed | 2024-03-09T00:36:56Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Fungi |
| spelling | doaj.art-ddd1aaa3ea1240f1a3d93ff4e4d34e6b2023-12-11T18:06:35ZengMDPI AGJournal of Fungi2309-608X2021-02-017215710.3390/jof7020157Paracoccidioidomycosis Diagnosed in Europe—A Systematic Literature ReviewGernot Wagner0Deddo Moertl1Anna Glechner2Verena Mayr3Irma Klerings4Casey Zachariah5Miriam Van den Nest6Gerald Gartlehner7Birgit Willinger8Department for Evidence-Based Medicine and Evaluation, Danube University Krems, Dr.-Karl-Dorrek-Strasse 30, 3500 Krems, AustriaClinical Department of Internal Medicine III, University Hospital St. Poelten, Karl Landsteiner University of Health Sciences, Dunant-Platz 1, 3100 St. Poelten, AustriaDepartment for Evidence-Based Medicine and Evaluation, Danube University Krems, Dr.-Karl-Dorrek-Strasse 30, 3500 Krems, AustriaDepartment for Evidence-Based Medicine and Evaluation, Danube University Krems, Dr.-Karl-Dorrek-Strasse 30, 3500 Krems, AustriaDepartment for Evidence-Based Medicine and Evaluation, Danube University Krems, Dr.-Karl-Dorrek-Strasse 30, 3500 Krems, AustriaDepartment for Evidence-Based Medicine and Evaluation, Danube University Krems, Dr.-Karl-Dorrek-Strasse 30, 3500 Krems, AustriaDepartment for Infection Control and Hospital Epidemiology, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, AustriaDepartment for Evidence-Based Medicine and Evaluation, Danube University Krems, Dr.-Karl-Dorrek-Strasse 30, 3500 Krems, AustriaDivision of Clinical Microbiology, Department of Laboratory Medicine, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, AustriaParacoccidioidomycosis is a systemic mycosis that is endemic in geographical regions of Central and South America. Cases that occur in nonendemic regions of the world are imported through migration and travel. Due to the limited number of cases in Europe, most physicians are not familiar with paracoccidioidomycosis and its close clinical and histopathological resemblance to other infectious and noninfectious disease. To increase awareness of this insidious mycosis, we conducted a systematic review to summarize the evidence on cases diagnosed and reported in Europe. We searched PubMed and Embase to identify cases of paracoccidioidomycosis diagnosed in European countries. In addition, we used Scopus for citation tracking and manually screened bibliographies of relevant articles. We conducted dual abstract and full-text screening of references yielded by our searches. To identify publications published prior to 1985, we used the previously published review by Ajello et al. Overall, we identified 83 cases of paracoccidioidomycosis diagnosed in 11 European countries, published in 68 articles. Age of patients ranged from 24 to 77 years; the majority were male. Time from leaving the endemic region and first occurrence of symptoms considerably varied. Our review illustrates the challenges of considering systemic mycosis in the differential diagnosis of people returning or immigrating to Europe from endemic areas. Travel history is important for diagnostic-workup, though it might be difficult to obtain due to possible long latency period of the disease.https://www.mdpi.com/2309-608X/7/2/157paracoccidioidomycosis<i>Paracoccidioides</i> spp.endemic systemic mycosis |
| spellingShingle | Gernot Wagner Deddo Moertl Anna Glechner Verena Mayr Irma Klerings Casey Zachariah Miriam Van den Nest Gerald Gartlehner Birgit Willinger Paracoccidioidomycosis Diagnosed in Europe—A Systematic Literature Review Journal of Fungi paracoccidioidomycosis <i>Paracoccidioides</i> spp. endemic systemic mycosis |
| title | Paracoccidioidomycosis Diagnosed in Europe—A Systematic Literature Review |
| title_full | Paracoccidioidomycosis Diagnosed in Europe—A Systematic Literature Review |
| title_fullStr | Paracoccidioidomycosis Diagnosed in Europe—A Systematic Literature Review |
| title_full_unstemmed | Paracoccidioidomycosis Diagnosed in Europe—A Systematic Literature Review |
| title_short | Paracoccidioidomycosis Diagnosed in Europe—A Systematic Literature Review |
| title_sort | paracoccidioidomycosis diagnosed in europe a systematic literature review |
| topic | paracoccidioidomycosis <i>Paracoccidioides</i> spp. endemic systemic mycosis |
| url | https://www.mdpi.com/2309-608X/7/2/157 |
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