Retrospective investigation of the origin and epidemiology of the dengue outbreak in Yunnan, China from 2017 to 2018
Since 2013, a dengue epidemic has broken out in Yunnan, China and neighboring countries. However, after the COVID-19 pandemic in 2019, the number of dengue cases decreased significantly. In this retrospective study, epidemiological and genetic diversity characterizations of dengue viruses (DENV) iso...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Veterinary Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2023.1137392/full |
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| author | Liang Cao Ziping Yu Haiqiang He Xiaofang Guo Chun Wei Xuancheng Zhang Junduo Bao Chenghui Li Hongning Zhou Jialiang Xin Fulong Nan |
| author_facet | Liang Cao Ziping Yu Haiqiang He Xiaofang Guo Chun Wei Xuancheng Zhang Junduo Bao Chenghui Li Hongning Zhou Jialiang Xin Fulong Nan |
| author_sort | Liang Cao |
| collection | DOAJ |
| description | Since 2013, a dengue epidemic has broken out in Yunnan, China and neighboring countries. However, after the COVID-19 pandemic in 2019, the number of dengue cases decreased significantly. In this retrospective study, epidemiological and genetic diversity characterizations of dengue viruses (DENV) isolated in Yunnan between 2017 and 2018 were performed. The results showed that the dengue outbreak in Yunnan from 2017 to 2018 was mainly caused by DENV1 (genotype I and genotype V) and DENV2 (Asia I, Asia II, and Cosmopolitan). Furthermore, correlation analysis indicated a significant positive correlation between the number of imported and local cases (correlation coefficient = 0.936). Multiple sequence alignment and phylogenetic divergence analysis revealed that the local isolates are closely related to the isolates from Myanmar and Laos. Interestingly, recombination analysis found that the DENV1 and DENV2 isolates in this study had widespread intra-serotype recombination. Taken together, the results of the epidemiological investigation imply that the dengue outbreak in Yunnan was primarily due to imported cases. This study provides a new reference for further investigations on the prevalence and molecular epidemiology of DENV in Yunnan, China. |
| first_indexed | 2024-04-09T18:19:21Z |
| format | Article |
| id | doaj.art-ddd39b31d561402eb38059ea0d5cdec1 |
| institution | Directory Open Access Journal |
| issn | 2297-1769 |
| language | English |
| last_indexed | 2024-04-09T18:19:21Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj.art-ddd39b31d561402eb38059ea0d5cdec12023-04-12T13:34:03ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692023-04-011010.3389/fvets.2023.11373921137392Retrospective investigation of the origin and epidemiology of the dengue outbreak in Yunnan, China from 2017 to 2018Liang Cao0Ziping Yu1Haiqiang He2Xiaofang Guo3Chun Wei4Xuancheng Zhang5Junduo Bao6Chenghui Li7Hongning Zhou8Jialiang Xin9Fulong Nan10College of Laboratory, Jilin Medical University, Jilin, ChinaInstitute of Virology, Wenzhou University, Wenzhou, ChinaCollege of Veterinary Medicine, Jilin University, Changchun, ChinaYunnan Institute of Parasitic Diseases, Pu'er, Yunnan, ChinaYunnan Institute of Parasitic Diseases, Pu'er, Yunnan, ChinaCollege of Veterinary Medicine, Jilin University, Changchun, ChinaCollage of Agriculture, Yanbian University, Yanbian, ChinaCollage of Agriculture, Yanbian University, Yanbian, ChinaYunnan Institute of Parasitic Diseases, Pu'er, Yunnan, ChinaCollege of Veterinary Medicine, Sichuan Agricultural University, Chengdu, ChinaDepartment of Special Medicine, School of Basic Medicine, Qingdao University, Qingdao, ChinaSince 2013, a dengue epidemic has broken out in Yunnan, China and neighboring countries. However, after the COVID-19 pandemic in 2019, the number of dengue cases decreased significantly. In this retrospective study, epidemiological and genetic diversity characterizations of dengue viruses (DENV) isolated in Yunnan between 2017 and 2018 were performed. The results showed that the dengue outbreak in Yunnan from 2017 to 2018 was mainly caused by DENV1 (genotype I and genotype V) and DENV2 (Asia I, Asia II, and Cosmopolitan). Furthermore, correlation analysis indicated a significant positive correlation between the number of imported and local cases (correlation coefficient = 0.936). Multiple sequence alignment and phylogenetic divergence analysis revealed that the local isolates are closely related to the isolates from Myanmar and Laos. Interestingly, recombination analysis found that the DENV1 and DENV2 isolates in this study had widespread intra-serotype recombination. Taken together, the results of the epidemiological investigation imply that the dengue outbreak in Yunnan was primarily due to imported cases. This study provides a new reference for further investigations on the prevalence and molecular epidemiology of DENV in Yunnan, China.https://www.frontiersin.org/articles/10.3389/fvets.2023.1137392/fulldengue virusepidemiologyphylogenetic analysisYunnan2017–2018 |
| spellingShingle | Liang Cao Ziping Yu Haiqiang He Xiaofang Guo Chun Wei Xuancheng Zhang Junduo Bao Chenghui Li Hongning Zhou Jialiang Xin Fulong Nan Retrospective investigation of the origin and epidemiology of the dengue outbreak in Yunnan, China from 2017 to 2018 Frontiers in Veterinary Science dengue virus epidemiology phylogenetic analysis Yunnan 2017–2018 |
| title | Retrospective investigation of the origin and epidemiology of the dengue outbreak in Yunnan, China from 2017 to 2018 |
| title_full | Retrospective investigation of the origin and epidemiology of the dengue outbreak in Yunnan, China from 2017 to 2018 |
| title_fullStr | Retrospective investigation of the origin and epidemiology of the dengue outbreak in Yunnan, China from 2017 to 2018 |
| title_full_unstemmed | Retrospective investigation of the origin and epidemiology of the dengue outbreak in Yunnan, China from 2017 to 2018 |
| title_short | Retrospective investigation of the origin and epidemiology of the dengue outbreak in Yunnan, China from 2017 to 2018 |
| title_sort | retrospective investigation of the origin and epidemiology of the dengue outbreak in yunnan china from 2017 to 2018 |
| topic | dengue virus epidemiology phylogenetic analysis Yunnan 2017–2018 |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2023.1137392/full |
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