Pharmacist-Driven Antibiotic Stewardship Program in Febrile Neutropenic Patients: A Single Site Prospective Study in Thailand
The antibiotic stewardship program (ASP) is a necessary part of febrile neutropenia (FN) treatment. Pharmacist-driven ASP is one of the meaningful approaches to improve the appropriateness of antibiotic usage. Our study aimed to determine role of the pharmacist in ASPs for FN patients. We prospectiv...
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MDPI AG
2021-04-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/10/4/456 |
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| author | Kittiya Jantarathaneewat Anucha Apisarnthanarak Wasithep Limvorapitak David J. Weber Preecha Montakantikul |
| author_facet | Kittiya Jantarathaneewat Anucha Apisarnthanarak Wasithep Limvorapitak David J. Weber Preecha Montakantikul |
| author_sort | Kittiya Jantarathaneewat |
| collection | DOAJ |
| description | The antibiotic stewardship program (ASP) is a necessary part of febrile neutropenia (FN) treatment. Pharmacist-driven ASP is one of the meaningful approaches to improve the appropriateness of antibiotic usage. Our study aimed to determine role of the pharmacist in ASPs for FN patients. We prospectively studied at Thammasat University Hospital between August 2019 and April 2020. Our primary outcome was to compare the appropriate use of target antibiotics between the pharmacist-driven ASP group and the control group. The results showed 90 FN events in 66 patients. The choice of an appropriate antibiotic was significantly higher in the pharmacist-driven ASP group than the control group (88.9% vs. 51.1%, <i>p</i> < 0.001). Furthermore, there was greater appropriateness of the dosage regimen chosen as empirical therapy in the pharmacist-driven ASP group than in the control group (97.8% vs. 88.7%, <i>p</i> = 0.049) and proper duration of target antibiotics in documentation therapy (91.1% vs. 75.6%, <i>p</i> = 0.039). The multivariate analysis showed a pharmacist-driven ASP and infectious diseases consultation had a favorable impact on 30-day infectious diseases-related mortality in chemotherapy-induced FN patients (OR 0.058, 95%CI:0.005–0.655, <i>p</i> = 0.021). Our study demonstrated that pharmacist-driven ASPs could be a great opportunity to improve antibiotic appropriateness in FN patients. |
| first_indexed | 2024-03-10T12:14:53Z |
| format | Article |
| id | doaj.art-ddd458e9940b4fc79e764eb2fd8eacdd |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-10T12:14:53Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-ddd458e9940b4fc79e764eb2fd8eacdd2023-11-21T15:58:59ZengMDPI AGAntibiotics2079-63822021-04-0110445610.3390/antibiotics10040456Pharmacist-Driven Antibiotic Stewardship Program in Febrile Neutropenic Patients: A Single Site Prospective Study in ThailandKittiya Jantarathaneewat0Anucha Apisarnthanarak1Wasithep Limvorapitak2David J. Weber3Preecha Montakantikul4Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok 10400, ThailandDivision of Infectious Diseases, Faculty of Medicine, Thammasat University, Pathum Thani 12120, ThailandDivision of Hematology, Faculty of Medicine, Thammasat University, Pathum Thani 12120, ThailandSchool of Global Public Health, University of North Carolina, Gillings, Chapel Hill, NC 27599-7400, USADepartment of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok 10400, ThailandThe antibiotic stewardship program (ASP) is a necessary part of febrile neutropenia (FN) treatment. Pharmacist-driven ASP is one of the meaningful approaches to improve the appropriateness of antibiotic usage. Our study aimed to determine role of the pharmacist in ASPs for FN patients. We prospectively studied at Thammasat University Hospital between August 2019 and April 2020. Our primary outcome was to compare the appropriate use of target antibiotics between the pharmacist-driven ASP group and the control group. The results showed 90 FN events in 66 patients. The choice of an appropriate antibiotic was significantly higher in the pharmacist-driven ASP group than the control group (88.9% vs. 51.1%, <i>p</i> < 0.001). Furthermore, there was greater appropriateness of the dosage regimen chosen as empirical therapy in the pharmacist-driven ASP group than in the control group (97.8% vs. 88.7%, <i>p</i> = 0.049) and proper duration of target antibiotics in documentation therapy (91.1% vs. 75.6%, <i>p</i> = 0.039). The multivariate analysis showed a pharmacist-driven ASP and infectious diseases consultation had a favorable impact on 30-day infectious diseases-related mortality in chemotherapy-induced FN patients (OR 0.058, 95%CI:0.005–0.655, <i>p</i> = 0.021). Our study demonstrated that pharmacist-driven ASPs could be a great opportunity to improve antibiotic appropriateness in FN patients.https://www.mdpi.com/2079-6382/10/4/456antibiotic stewardshipfebrile neutropeniaappropriatenesspharmacist-drivenhematology oncologic patient |
| spellingShingle | Kittiya Jantarathaneewat Anucha Apisarnthanarak Wasithep Limvorapitak David J. Weber Preecha Montakantikul Pharmacist-Driven Antibiotic Stewardship Program in Febrile Neutropenic Patients: A Single Site Prospective Study in Thailand Antibiotics antibiotic stewardship febrile neutropenia appropriateness pharmacist-driven hematology oncologic patient |
| title | Pharmacist-Driven Antibiotic Stewardship Program in Febrile Neutropenic Patients: A Single Site Prospective Study in Thailand |
| title_full | Pharmacist-Driven Antibiotic Stewardship Program in Febrile Neutropenic Patients: A Single Site Prospective Study in Thailand |
| title_fullStr | Pharmacist-Driven Antibiotic Stewardship Program in Febrile Neutropenic Patients: A Single Site Prospective Study in Thailand |
| title_full_unstemmed | Pharmacist-Driven Antibiotic Stewardship Program in Febrile Neutropenic Patients: A Single Site Prospective Study in Thailand |
| title_short | Pharmacist-Driven Antibiotic Stewardship Program in Febrile Neutropenic Patients: A Single Site Prospective Study in Thailand |
| title_sort | pharmacist driven antibiotic stewardship program in febrile neutropenic patients a single site prospective study in thailand |
| topic | antibiotic stewardship febrile neutropenia appropriateness pharmacist-driven hematology oncologic patient |
| url | https://www.mdpi.com/2079-6382/10/4/456 |
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