Métabolisme oxygéné des acides gras polyinsaturés et fonction dans les cellules sanguines et vasculaires1

Most polyunsaturated fatty acids have the minimal 1,4-cis,cis-pentadiene configuration to be oxygenated into a conjugated diene hydroperoxide. This product is usually reduced into the corresponding hydroxy derivative by cell glutathione peroxidases. A series of mono-, di- and tri-hydroxy derivatives...

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Main Author: Lagarde Michel
Format: Article
Language:English
Published: EDP Sciences 2011-03-01
Series:Oléagineux, Corps gras, Lipides
Subjects:
Online Access:http://dx.doi.org/10.1051/ocl.2011.0377
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author Lagarde Michel
author_facet Lagarde Michel
author_sort Lagarde Michel
collection DOAJ
description Most polyunsaturated fatty acids have the minimal 1,4-cis,cis-pentadiene configuration to be oxygenated into a conjugated diene hydroperoxide. This product is usually reduced into the corresponding hydroxy derivative by cell glutathione peroxidases. A series of mono-, di- and tri-hydroxy derivatives can then be formed. In addition, eicosapolyenoic acids having at least three double bonds at carbons 8, 11 and 14 are oxygenated and cyclised by cyclooxygenases into prostanoids, as well as some docosapolyenoic counterparts with at least three double bonds at carbons 10, 13 and 16, but to a lesser extent. Most of those oxygenated metabolites have been described with specific biological functions, especially in blood and vascular cells. Few cytochrome P450 mono-oxygenases products have been described as well with less characterized biological functions.
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spelling doaj.art-ddd4d07cd9464ea3843fd94f9c59993b2022-12-21T22:50:55ZengEDP SciencesOléagineux, Corps gras, Lipides1258-82101950-697X2011-03-01182475210.1051/ocl.2011.0377ocl2011182p47Métabolisme oxygéné des acides gras polyinsaturés et fonction dans les cellules sanguines et vasculaires1Lagarde MichelMost polyunsaturated fatty acids have the minimal 1,4-cis,cis-pentadiene configuration to be oxygenated into a conjugated diene hydroperoxide. This product is usually reduced into the corresponding hydroxy derivative by cell glutathione peroxidases. A series of mono-, di- and tri-hydroxy derivatives can then be formed. In addition, eicosapolyenoic acids having at least three double bonds at carbons 8, 11 and 14 are oxygenated and cyclised by cyclooxygenases into prostanoids, as well as some docosapolyenoic counterparts with at least three double bonds at carbons 10, 13 and 16, but to a lesser extent. Most of those oxygenated metabolites have been described with specific biological functions, especially in blood and vascular cells. Few cytochrome P450 mono-oxygenases products have been described as well with less characterized biological functions.http://dx.doi.org/10.1051/ocl.2011.0377oxygenasesprostanoidsleukotrienesprotectinsresolvinsoctadecanoidsdocosanoids
spellingShingle Lagarde Michel
Métabolisme oxygéné des acides gras polyinsaturés et fonction dans les cellules sanguines et vasculaires1
Oléagineux, Corps gras, Lipides
oxygenases
prostanoids
leukotrienes
protectins
resolvins
octadecanoids
docosanoids
title Métabolisme oxygéné des acides gras polyinsaturés et fonction dans les cellules sanguines et vasculaires1
title_full Métabolisme oxygéné des acides gras polyinsaturés et fonction dans les cellules sanguines et vasculaires1
title_fullStr Métabolisme oxygéné des acides gras polyinsaturés et fonction dans les cellules sanguines et vasculaires1
title_full_unstemmed Métabolisme oxygéné des acides gras polyinsaturés et fonction dans les cellules sanguines et vasculaires1
title_short Métabolisme oxygéné des acides gras polyinsaturés et fonction dans les cellules sanguines et vasculaires1
title_sort metabolisme oxygene des acides gras polyinsatures et fonction dans les cellules sanguines et vasculaires1
topic oxygenases
prostanoids
leukotrienes
protectins
resolvins
octadecanoids
docosanoids
url http://dx.doi.org/10.1051/ocl.2011.0377
work_keys_str_mv AT lagardemichel metabolismeoxygenedesacidesgraspolyinsaturesetfonctiondanslescellulessanguinesetvasculaires1