Métabolisme oxygéné des acides gras polyinsaturés et fonction dans les cellules sanguines et vasculaires1
Most polyunsaturated fatty acids have the minimal 1,4-cis,cis-pentadiene configuration to be oxygenated into a conjugated diene hydroperoxide. This product is usually reduced into the corresponding hydroxy derivative by cell glutathione peroxidases. A series of mono-, di- and tri-hydroxy derivatives...
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Format: | Article |
Language: | English |
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EDP Sciences
2011-03-01
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Series: | Oléagineux, Corps gras, Lipides |
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Online Access: | http://dx.doi.org/10.1051/ocl.2011.0377 |
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author | Lagarde Michel |
author_facet | Lagarde Michel |
author_sort | Lagarde Michel |
collection | DOAJ |
description | Most polyunsaturated fatty acids have the minimal 1,4-cis,cis-pentadiene configuration to be oxygenated into a conjugated diene hydroperoxide. This product is usually reduced into the corresponding hydroxy derivative by cell glutathione peroxidases. A series of mono-, di- and tri-hydroxy derivatives can then be formed. In addition, eicosapolyenoic acids having at least three double bonds at carbons 8, 11 and 14 are oxygenated and cyclised by cyclooxygenases into prostanoids, as well as some docosapolyenoic counterparts with at least three double bonds at carbons 10, 13 and 16, but to a lesser extent. Most of those oxygenated metabolites have been described with specific biological functions, especially in blood and vascular cells. Few cytochrome P450 mono-oxygenases products have been described as well with less characterized biological functions. |
first_indexed | 2024-12-14T19:03:25Z |
format | Article |
id | doaj.art-ddd4d07cd9464ea3843fd94f9c59993b |
institution | Directory Open Access Journal |
issn | 1258-8210 1950-697X |
language | English |
last_indexed | 2024-12-14T19:03:25Z |
publishDate | 2011-03-01 |
publisher | EDP Sciences |
record_format | Article |
series | Oléagineux, Corps gras, Lipides |
spelling | doaj.art-ddd4d07cd9464ea3843fd94f9c59993b2022-12-21T22:50:55ZengEDP SciencesOléagineux, Corps gras, Lipides1258-82101950-697X2011-03-01182475210.1051/ocl.2011.0377ocl2011182p47Métabolisme oxygéné des acides gras polyinsaturés et fonction dans les cellules sanguines et vasculaires1Lagarde MichelMost polyunsaturated fatty acids have the minimal 1,4-cis,cis-pentadiene configuration to be oxygenated into a conjugated diene hydroperoxide. This product is usually reduced into the corresponding hydroxy derivative by cell glutathione peroxidases. A series of mono-, di- and tri-hydroxy derivatives can then be formed. In addition, eicosapolyenoic acids having at least three double bonds at carbons 8, 11 and 14 are oxygenated and cyclised by cyclooxygenases into prostanoids, as well as some docosapolyenoic counterparts with at least three double bonds at carbons 10, 13 and 16, but to a lesser extent. Most of those oxygenated metabolites have been described with specific biological functions, especially in blood and vascular cells. Few cytochrome P450 mono-oxygenases products have been described as well with less characterized biological functions.http://dx.doi.org/10.1051/ocl.2011.0377oxygenasesprostanoidsleukotrienesprotectinsresolvinsoctadecanoidsdocosanoids |
spellingShingle | Lagarde Michel Métabolisme oxygéné des acides gras polyinsaturés et fonction dans les cellules sanguines et vasculaires1 Oléagineux, Corps gras, Lipides oxygenases prostanoids leukotrienes protectins resolvins octadecanoids docosanoids |
title | Métabolisme oxygéné des acides gras polyinsaturés et fonction dans les cellules sanguines et vasculaires1 |
title_full | Métabolisme oxygéné des acides gras polyinsaturés et fonction dans les cellules sanguines et vasculaires1 |
title_fullStr | Métabolisme oxygéné des acides gras polyinsaturés et fonction dans les cellules sanguines et vasculaires1 |
title_full_unstemmed | Métabolisme oxygéné des acides gras polyinsaturés et fonction dans les cellules sanguines et vasculaires1 |
title_short | Métabolisme oxygéné des acides gras polyinsaturés et fonction dans les cellules sanguines et vasculaires1 |
title_sort | metabolisme oxygene des acides gras polyinsatures et fonction dans les cellules sanguines et vasculaires1 |
topic | oxygenases prostanoids leukotrienes protectins resolvins octadecanoids docosanoids |
url | http://dx.doi.org/10.1051/ocl.2011.0377 |
work_keys_str_mv | AT lagardemichel metabolismeoxygenedesacidesgraspolyinsaturesetfonctiondanslescellulessanguinesetvasculaires1 |