Acute Macular Neuroretinopathy after SARS-CoV-2 Infection: An Analysis of Clinical and Multimodal Imaging Characteristics
Background: This study aimed to analyze clinical and multimodal imaging characteristics of acute macular neuroretinopathy (AMN) post-recent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Methods: Retrospective observational study. Medical records and multimodal imaging of 12...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/24/3600 |
| _version_ | 1797381484826329088 |
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| author | Jiyang Tang Siying Li Zongyi Wang Ye Tao Linqi Zhang Hong Yin Heng Miao Yaoyao Sun Jinfeng Qu |
| author_facet | Jiyang Tang Siying Li Zongyi Wang Ye Tao Linqi Zhang Hong Yin Heng Miao Yaoyao Sun Jinfeng Qu |
| author_sort | Jiyang Tang |
| collection | DOAJ |
| description | Background: This study aimed to analyze clinical and multimodal imaging characteristics of acute macular neuroretinopathy (AMN) post-recent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Methods: Retrospective observational study. Medical records and multimodal imaging of 12 AMN eyes of eight patients (six female and two male) with recent SARS-CoV-2 infection were retrospectively analyzed. Results: Four patients (50%) presented with bilateral AMN. Fundus ophthalmoscopy revealed a reddish-brown lesion around the macula, and two eyes had cotton-wool spots at the posterior pole. Three eyes showed mild hypo-autofluorescence. All FFA images (7 eyes) showed no abnormal signs. On OCT scans, all eyes showed outer nuclear layer (ONL) thinning, 8 eyes (66.7%) showed ONL hyperreflectivity, 5 eyes (41.7%) showed outer plexiform layer (OPL) hyperreflectivity, 8 eyes (66.7%) showed interdigitation zone (IZ) disruption, 11 eyes (91.6%) showed ellipsoid zone (EZ) disruption, 2 eyes (16.7%) showed cotton-wool spots and inner plexiform layer (IPL) hyperreflectivity, 1 eye (8.3%) had intraretinal cyst and 1 eye (8.3%) had inner nuclear layer (INL) thinning. Persistent scotoma, ONL hyperreflectivity and IZ/EZ disruption as well as recovery of OPL hyperreflectivity were reported after follow-up in three cases. Conclusions: AMN post-SARS-CoV-2 mostly affected young females and could present unilaterally or bilaterally. Dark lesions on IR reflectance and outer retinal hyperreflectivity on OCT are useful in diagnosing AMN. OPL/ONL hyperreflectivity on OCT could disappear after follow-up, but ONL thinning and IZ/EZ could persist. |
| first_indexed | 2024-03-08T20:52:13Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-08T20:52:13Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-ddd517b2ea894223804fd39d05d458fa2023-12-22T14:03:00ZengMDPI AGDiagnostics2075-44182023-12-011324360010.3390/diagnostics13243600Acute Macular Neuroretinopathy after SARS-CoV-2 Infection: An Analysis of Clinical and Multimodal Imaging CharacteristicsJiyang Tang0Siying Li1Zongyi Wang2Ye Tao3Linqi Zhang4Hong Yin5Heng Miao6Yaoyao Sun7Jinfeng Qu8Department of Ophthalmology, Peking University People’s Hospital, Beijing 100044, ChinaDepartment of Ophthalmology, Peking University People’s Hospital, Beijing 100044, ChinaDepartment of Ophthalmology, Peking University People’s Hospital, Beijing 100044, ChinaDepartment of Ophthalmology, Peking University People’s Hospital, Beijing 100044, ChinaDepartment of Ophthalmology, Peking University People’s Hospital, Beijing 100044, ChinaDepartment of Ophthalmology, Peking University People’s Hospital, Beijing 100044, ChinaDepartment of Ophthalmology, Peking University People’s Hospital, Beijing 100044, ChinaDepartment of Ophthalmology, Peking University People’s Hospital, Beijing 100044, ChinaDepartment of Ophthalmology, Peking University People’s Hospital, Beijing 100044, ChinaBackground: This study aimed to analyze clinical and multimodal imaging characteristics of acute macular neuroretinopathy (AMN) post-recent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Methods: Retrospective observational study. Medical records and multimodal imaging of 12 AMN eyes of eight patients (six female and two male) with recent SARS-CoV-2 infection were retrospectively analyzed. Results: Four patients (50%) presented with bilateral AMN. Fundus ophthalmoscopy revealed a reddish-brown lesion around the macula, and two eyes had cotton-wool spots at the posterior pole. Three eyes showed mild hypo-autofluorescence. All FFA images (7 eyes) showed no abnormal signs. On OCT scans, all eyes showed outer nuclear layer (ONL) thinning, 8 eyes (66.7%) showed ONL hyperreflectivity, 5 eyes (41.7%) showed outer plexiform layer (OPL) hyperreflectivity, 8 eyes (66.7%) showed interdigitation zone (IZ) disruption, 11 eyes (91.6%) showed ellipsoid zone (EZ) disruption, 2 eyes (16.7%) showed cotton-wool spots and inner plexiform layer (IPL) hyperreflectivity, 1 eye (8.3%) had intraretinal cyst and 1 eye (8.3%) had inner nuclear layer (INL) thinning. Persistent scotoma, ONL hyperreflectivity and IZ/EZ disruption as well as recovery of OPL hyperreflectivity were reported after follow-up in three cases. Conclusions: AMN post-SARS-CoV-2 mostly affected young females and could present unilaterally or bilaterally. Dark lesions on IR reflectance and outer retinal hyperreflectivity on OCT are useful in diagnosing AMN. OPL/ONL hyperreflectivity on OCT could disappear after follow-up, but ONL thinning and IZ/EZ could persist.https://www.mdpi.com/2075-4418/13/24/3600acute macular neuroretinopathySARS-CoV-2multimodal imaging |
| spellingShingle | Jiyang Tang Siying Li Zongyi Wang Ye Tao Linqi Zhang Hong Yin Heng Miao Yaoyao Sun Jinfeng Qu Acute Macular Neuroretinopathy after SARS-CoV-2 Infection: An Analysis of Clinical and Multimodal Imaging Characteristics Diagnostics acute macular neuroretinopathy SARS-CoV-2 multimodal imaging |
| title | Acute Macular Neuroretinopathy after SARS-CoV-2 Infection: An Analysis of Clinical and Multimodal Imaging Characteristics |
| title_full | Acute Macular Neuroretinopathy after SARS-CoV-2 Infection: An Analysis of Clinical and Multimodal Imaging Characteristics |
| title_fullStr | Acute Macular Neuroretinopathy after SARS-CoV-2 Infection: An Analysis of Clinical and Multimodal Imaging Characteristics |
| title_full_unstemmed | Acute Macular Neuroretinopathy after SARS-CoV-2 Infection: An Analysis of Clinical and Multimodal Imaging Characteristics |
| title_short | Acute Macular Neuroretinopathy after SARS-CoV-2 Infection: An Analysis of Clinical and Multimodal Imaging Characteristics |
| title_sort | acute macular neuroretinopathy after sars cov 2 infection an analysis of clinical and multimodal imaging characteristics |
| topic | acute macular neuroretinopathy SARS-CoV-2 multimodal imaging |
| url | https://www.mdpi.com/2075-4418/13/24/3600 |
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