Preparação e caracterização de suspensões coloidais de nanocarreadores lipídicos contendo resveratrol destinados à administração cutânea
Solid lipid nanoparticles (SLN), nanoemulsions (NE), and microemulsions (ME) were prepared by the hot solvent diffusion method, using tristearin or castor oil as oily phase, and soy lecithin and Solutol HS 15 as surfactants. Mean particle sizes ranged from 20 to 215 nm and negative zeta potentials w...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Química
2011-01-01
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| Series: | Química Nova |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000300008&lng=en&tlng=en |
| _version_ | 1828416138544939008 |
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| author | Daiane Nemen Elenara Lemos-Senna |
| author_facet | Daiane Nemen Elenara Lemos-Senna |
| author_sort | Daiane Nemen |
| collection | DOAJ |
| description | Solid lipid nanoparticles (SLN), nanoemulsions (NE), and microemulsions (ME) were prepared by the hot solvent diffusion method, using tristearin or castor oil as oily phase, and soy lecithin and Solutol HS 15 as surfactants. Mean particle sizes ranged from 20 to 215 nm and negative zeta potentials were obtained for all nanocarriers. A HPLC method used to determine resveratrol was specific, linear, exact and precise. The entrapment efficiency was high for all formulations. However, resveratrol content was significantly varied among the lipid nanocarriers. Lipid nanocarrier containing hydrogels exhibiting pseudoplastic behavior were obtained after incorporation of hydroxyethylcellulose in the colloidal dispersions. |
| first_indexed | 2024-12-10T13:57:37Z |
| format | Article |
| id | doaj.art-ddd5a5f5d3a7451bb782e93c44543011 |
| institution | Directory Open Access Journal |
| issn | 1678-7064 |
| language | English |
| last_indexed | 2024-12-10T13:57:37Z |
| publishDate | 2011-01-01 |
| publisher | Sociedade Brasileira de Química |
| record_format | Article |
| series | Química Nova |
| spelling | doaj.art-ddd5a5f5d3a7451bb782e93c445430112022-12-22T01:45:54ZengSociedade Brasileira de QuímicaQuímica Nova1678-70642011-01-0134340841310.1590/S0100-40422011000300008S0100-40422011000300008Preparação e caracterização de suspensões coloidais de nanocarreadores lipídicos contendo resveratrol destinados à administração cutâneaDaiane Nemen0Elenara Lemos-Senna1Universidade Federal de Santa CatarinaUniversidade Federal de Santa CatarinaSolid lipid nanoparticles (SLN), nanoemulsions (NE), and microemulsions (ME) were prepared by the hot solvent diffusion method, using tristearin or castor oil as oily phase, and soy lecithin and Solutol HS 15 as surfactants. Mean particle sizes ranged from 20 to 215 nm and negative zeta potentials were obtained for all nanocarriers. A HPLC method used to determine resveratrol was specific, linear, exact and precise. The entrapment efficiency was high for all formulations. However, resveratrol content was significantly varied among the lipid nanocarriers. Lipid nanocarrier containing hydrogels exhibiting pseudoplastic behavior were obtained after incorporation of hydroxyethylcellulose in the colloidal dispersions.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000300008&lng=en&tlng=enresveratrollipid-based nanocarriershydrogels |
| spellingShingle | Daiane Nemen Elenara Lemos-Senna Preparação e caracterização de suspensões coloidais de nanocarreadores lipídicos contendo resveratrol destinados à administração cutânea Química Nova resveratrol lipid-based nanocarriers hydrogels |
| title | Preparação e caracterização de suspensões coloidais de nanocarreadores lipídicos contendo resveratrol destinados à administração cutânea |
| title_full | Preparação e caracterização de suspensões coloidais de nanocarreadores lipídicos contendo resveratrol destinados à administração cutânea |
| title_fullStr | Preparação e caracterização de suspensões coloidais de nanocarreadores lipídicos contendo resveratrol destinados à administração cutânea |
| title_full_unstemmed | Preparação e caracterização de suspensões coloidais de nanocarreadores lipídicos contendo resveratrol destinados à administração cutânea |
| title_short | Preparação e caracterização de suspensões coloidais de nanocarreadores lipídicos contendo resveratrol destinados à administração cutânea |
| title_sort | preparacao e caracterizacao de suspensoes coloidais de nanocarreadores lipidicos contendo resveratrol destinados a administracao cutanea |
| topic | resveratrol lipid-based nanocarriers hydrogels |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000300008&lng=en&tlng=en |
| work_keys_str_mv | AT daianenemen preparacaoecaracterizacaodesuspensoescoloidaisdenanocarreadoreslipidicoscontendoresveratroldestinadosaadministracaocutanea AT elenaralemossenna preparacaoecaracterizacaodesuspensoescoloidaisdenanocarreadoreslipidicoscontendoresveratroldestinadosaadministracaocutanea |