Association between multiple vitamins and bone mineral density: a cross-sectional and population-based study in the NHANES from 2005 to 2006
Abstract Background Bone mineral density (BMD) alterations in response to multivitamin exposure were rarely studied. Our study assessed the association of coexposure to six types of vitamins (i.e., vitamins B12, B9, C, D, A and E) with BMD measurements in adults in the US. Methods Data were collecte...
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| Format: | Article |
| Language: | English |
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BMC
2023-02-01
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| Series: | BMC Musculoskeletal Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12891-023-06202-6 |
| _version_ | 1811166089275506688 |
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| author | Ruyi Zhang Qin Huang Guanhua Su Muhong Wei Yuan Cui Haolong Zhou Wenjing Song Dongsheng Di Junan Liu Qi Wang |
| author_facet | Ruyi Zhang Qin Huang Guanhua Su Muhong Wei Yuan Cui Haolong Zhou Wenjing Song Dongsheng Di Junan Liu Qi Wang |
| author_sort | Ruyi Zhang |
| collection | DOAJ |
| description | Abstract Background Bone mineral density (BMD) alterations in response to multivitamin exposure were rarely studied. Our study assessed the association of coexposure to six types of vitamins (i.e., vitamins B12, B9, C, D, A and E) with BMD measurements in adults in the US. Methods Data were collected from participants aged ≥ 20 years (n = 2757) in the U.S. National Health and Nutrition Examination Surveys (NHANES) from 2005 to 2006. Multiple linear regression, restricted cubic splines, principal component analysis (PCA) and weighted quantile sum (WQS) regression were performed for statistical analysis. Results The circulating levels of vitamins B12 and C were positively associated with BMDs, and an inverted L-shaped exposure relationship was observed between serum vitamin C and BMDs. PCA identified two principal components: one for ‘water-soluble vitamins’, including vitamins B12, B9 and C, and one for ‘fat-soluble vitamins’, including vitamins A, D and E. The former was positively associated with total femur (β = 0.009, 95%CI: 0.004, 0.015) and femoral neck (β = 0.007, 95%CI: 0.002, 0.013) BMDs, and the latter was negatively associated with BMDs with non-statistical significance. The WQS index constructed for the six vitamins was significantly related to total femur (β = 0.010, 95%CI: 0.001, 0.018) and femoral neck (β = 0.008, 95%CI: 0.001, 0.015) BMDs, and vitamins B12 and C weighted the most. The WQS index was inversely related to BMDs with non-statistical significance, and vitamins E and A weighted the most. Conclusion Our findings suggested a positive association between water-soluble vitamin coexposure and BMD, and the association was mainly driven by vitamins B12 and C. Negative association between fat-soluble vitamin coexposure and BMD was indicated, mainly driven by vitamins E and A. An inverted L-shaped exposure relationship was found between vitamin C and BMD. |
| first_indexed | 2024-04-10T15:47:54Z |
| format | Article |
| id | doaj.art-ddd5ff4aae0b459aa21a645368a684a7 |
| institution | Directory Open Access Journal |
| issn | 1471-2474 |
| language | English |
| last_indexed | 2024-04-10T15:47:54Z |
| publishDate | 2023-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Musculoskeletal Disorders |
| spelling | doaj.art-ddd5ff4aae0b459aa21a645368a684a72023-02-12T12:02:08ZengBMCBMC Musculoskeletal Disorders1471-24742023-02-0124111210.1186/s12891-023-06202-6Association between multiple vitamins and bone mineral density: a cross-sectional and population-based study in the NHANES from 2005 to 2006Ruyi Zhang0Qin Huang1Guanhua Su2Muhong Wei3Yuan Cui4Haolong Zhou5Wenjing Song6Dongsheng Di7Junan Liu8Qi Wang9MOE Key Lab of Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Rehabilitation Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyMOE Key Lab of Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and TechnologyMOE Key Lab of Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and TechnologyMOE Key Lab of Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and TechnologyMOE Key Lab of Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and TechnologyMOE Key Lab of Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Social Medicine and Health Management, School of Public Health, Tongji Medical College, Huazhong University of Science and TechnologyMOE Key Lab of Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and TechnologyAbstract Background Bone mineral density (BMD) alterations in response to multivitamin exposure were rarely studied. Our study assessed the association of coexposure to six types of vitamins (i.e., vitamins B12, B9, C, D, A and E) with BMD measurements in adults in the US. Methods Data were collected from participants aged ≥ 20 years (n = 2757) in the U.S. National Health and Nutrition Examination Surveys (NHANES) from 2005 to 2006. Multiple linear regression, restricted cubic splines, principal component analysis (PCA) and weighted quantile sum (WQS) regression were performed for statistical analysis. Results The circulating levels of vitamins B12 and C were positively associated with BMDs, and an inverted L-shaped exposure relationship was observed between serum vitamin C and BMDs. PCA identified two principal components: one for ‘water-soluble vitamins’, including vitamins B12, B9 and C, and one for ‘fat-soluble vitamins’, including vitamins A, D and E. The former was positively associated with total femur (β = 0.009, 95%CI: 0.004, 0.015) and femoral neck (β = 0.007, 95%CI: 0.002, 0.013) BMDs, and the latter was negatively associated with BMDs with non-statistical significance. The WQS index constructed for the six vitamins was significantly related to total femur (β = 0.010, 95%CI: 0.001, 0.018) and femoral neck (β = 0.008, 95%CI: 0.001, 0.015) BMDs, and vitamins B12 and C weighted the most. The WQS index was inversely related to BMDs with non-statistical significance, and vitamins E and A weighted the most. Conclusion Our findings suggested a positive association between water-soluble vitamin coexposure and BMD, and the association was mainly driven by vitamins B12 and C. Negative association between fat-soluble vitamin coexposure and BMD was indicated, mainly driven by vitamins E and A. An inverted L-shaped exposure relationship was found between vitamin C and BMD.https://doi.org/10.1186/s12891-023-06202-6Multiple vitamins co-exposureBone mineral densityWeighted quantile sum (WQS) regressionPrincipal components analysis (PCA) |
| spellingShingle | Ruyi Zhang Qin Huang Guanhua Su Muhong Wei Yuan Cui Haolong Zhou Wenjing Song Dongsheng Di Junan Liu Qi Wang Association between multiple vitamins and bone mineral density: a cross-sectional and population-based study in the NHANES from 2005 to 2006 BMC Musculoskeletal Disorders Multiple vitamins co-exposure Bone mineral density Weighted quantile sum (WQS) regression Principal components analysis (PCA) |
| title | Association between multiple vitamins and bone mineral density: a cross-sectional and population-based study in the NHANES from 2005 to 2006 |
| title_full | Association between multiple vitamins and bone mineral density: a cross-sectional and population-based study in the NHANES from 2005 to 2006 |
| title_fullStr | Association between multiple vitamins and bone mineral density: a cross-sectional and population-based study in the NHANES from 2005 to 2006 |
| title_full_unstemmed | Association between multiple vitamins and bone mineral density: a cross-sectional and population-based study in the NHANES from 2005 to 2006 |
| title_short | Association between multiple vitamins and bone mineral density: a cross-sectional and population-based study in the NHANES from 2005 to 2006 |
| title_sort | association between multiple vitamins and bone mineral density a cross sectional and population based study in the nhanes from 2005 to 2006 |
| topic | Multiple vitamins co-exposure Bone mineral density Weighted quantile sum (WQS) regression Principal components analysis (PCA) |
| url | https://doi.org/10.1186/s12891-023-06202-6 |
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