Does intra articular platelet rich plasma injection improve function, pain and quality of life in patients with osteoarthritis of the knee? A randomized clinical trial
We designed a randomized clinical trial with control group, to investigate the effects of platelet rich plasma (PRP) on pain, stiffness, function and quality of life in patients with knee osteoarthritis. Patients were randomly divided in two groups. For both groups of participants, therapeutic exerc...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Open Medical Publishing
2014-09-01
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| Series: | Orthopedic Reviews |
| Subjects: | |
| Online Access: | http://www.pagepress.org/journals/index.php/or/article/view/5405 |
| _version_ | 1818948121833504768 |
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| author | Seyed Mansoor Rayegani Seyed Ahmad Raeissadat Morteza Sanei Taheri Marzieh Babaee Mohammad Hassan Bahrami Dariush Eliaspour Elham Ghorbani |
| author_facet | Seyed Mansoor Rayegani Seyed Ahmad Raeissadat Morteza Sanei Taheri Marzieh Babaee Mohammad Hassan Bahrami Dariush Eliaspour Elham Ghorbani |
| author_sort | Seyed Mansoor Rayegani |
| collection | DOAJ |
| description | We designed a randomized clinical trial with control group, to investigate the effects of platelet rich plasma (PRP) on pain, stiffness, function and quality of life in patients with knee osteoarthritis. Patients were randomly divided in two groups. For both groups of participants, therapeutic exercise was prescribed. In the PRP group, two courses of leukocyte rich PRP (5.6 fold higher platelet concentration) with a 4-week interval was injected. For each participant, Western Ontario and McMaster University’s Arthritis Index (WOMAC) and the SF-36 questionnaire (Farsi version) were filled at the baseline and 6 months after treatments. Thirty-one patients in the PRP group and 31 patients in the control group were studied. Mean changes of total WOMAC, physical component summery and mental component summery of Short Form-36 in PRP group showed better improvement than control group (P<0.05). This study showed that intra articular PRP knee injection combined with therapeutic exercise can be more effective in pain reduction and improvement of stiffness and quality of life, compared with therapeutic exercise alone. |
| first_indexed | 2024-12-20T08:41:46Z |
| format | Article |
| id | doaj.art-ddd6537de4504edab75a0c46e75dcc48 |
| institution | Directory Open Access Journal |
| issn | 2035-8237 2035-8164 |
| language | English |
| last_indexed | 2024-12-20T08:41:46Z |
| publishDate | 2014-09-01 |
| publisher | Open Medical Publishing |
| record_format | Article |
| series | Orthopedic Reviews |
| spelling | doaj.art-ddd6537de4504edab75a0c46e75dcc482022-12-21T19:46:23ZengOpen Medical PublishingOrthopedic Reviews2035-82372035-81642014-09-016310.4081/or.2014.54052912Does intra articular platelet rich plasma injection improve function, pain and quality of life in patients with osteoarthritis of the knee? A randomized clinical trialSeyed Mansoor Rayegani0Seyed Ahmad Raeissadat1Morteza Sanei Taheri2Marzieh Babaee3Mohammad Hassan Bahrami4Dariush Eliaspour5Elham Ghorbani6Physical Medicine and Rehabilitation Department, Shohada-e-Tajrish HospitalPhysical Medicine and Rehabilitation Department, Shahid Modarres HospitalRadiology Department, Shohada-e-Tajrish Hospital, Shahid Beheshti University of Medical Sciences, TehranPhysical Medicine and Rehabilitation Department, Shohada-e-Tajrish HospitalPhysical Medicine and Rehabilitation Department, Shohada-e-Tajrish HospitalPhysical Medicine and Rehabilitation Department, Shohada-e-Tajrish HospitalPhysical Medicine and Rehabilitation Department, Shohada-e-Tajrish HospitalWe designed a randomized clinical trial with control group, to investigate the effects of platelet rich plasma (PRP) on pain, stiffness, function and quality of life in patients with knee osteoarthritis. Patients were randomly divided in two groups. For both groups of participants, therapeutic exercise was prescribed. In the PRP group, two courses of leukocyte rich PRP (5.6 fold higher platelet concentration) with a 4-week interval was injected. For each participant, Western Ontario and McMaster University’s Arthritis Index (WOMAC) and the SF-36 questionnaire (Farsi version) were filled at the baseline and 6 months after treatments. Thirty-one patients in the PRP group and 31 patients in the control group were studied. Mean changes of total WOMAC, physical component summery and mental component summery of Short Form-36 in PRP group showed better improvement than control group (P<0.05). This study showed that intra articular PRP knee injection combined with therapeutic exercise can be more effective in pain reduction and improvement of stiffness and quality of life, compared with therapeutic exercise alone.http://www.pagepress.org/journals/index.php/or/article/view/5405platelet rich plasma, therapeutic exercise, knee osteoarthritis |
| spellingShingle | Seyed Mansoor Rayegani Seyed Ahmad Raeissadat Morteza Sanei Taheri Marzieh Babaee Mohammad Hassan Bahrami Dariush Eliaspour Elham Ghorbani Does intra articular platelet rich plasma injection improve function, pain and quality of life in patients with osteoarthritis of the knee? A randomized clinical trial Orthopedic Reviews platelet rich plasma, therapeutic exercise, knee osteoarthritis |
| title | Does intra articular platelet rich plasma injection improve function, pain and quality of life in patients with osteoarthritis of the knee? A randomized clinical trial |
| title_full | Does intra articular platelet rich plasma injection improve function, pain and quality of life in patients with osteoarthritis of the knee? A randomized clinical trial |
| title_fullStr | Does intra articular platelet rich plasma injection improve function, pain and quality of life in patients with osteoarthritis of the knee? A randomized clinical trial |
| title_full_unstemmed | Does intra articular platelet rich plasma injection improve function, pain and quality of life in patients with osteoarthritis of the knee? A randomized clinical trial |
| title_short | Does intra articular platelet rich plasma injection improve function, pain and quality of life in patients with osteoarthritis of the knee? A randomized clinical trial |
| title_sort | does intra articular platelet rich plasma injection improve function pain and quality of life in patients with osteoarthritis of the knee a randomized clinical trial |
| topic | platelet rich plasma, therapeutic exercise, knee osteoarthritis |
| url | http://www.pagepress.org/journals/index.php/or/article/view/5405 |
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