A Transient π–π or Cation–π Interaction between Degron and Degrader Dual Residues: A Key Step for the Substrate Recognition and Discrimination in the Processive Degradation of SulA by ClpYQ (HslUV) Protease in <i>Escherichia coli</i>

A Transient π–π or Cation–π Interaction between Degron and Degrader Dual Residues: A Key Step for the Substrate Recognition and Discrimination in the Processive Degradation of SulA by ClpYQ (HslUV) Protease in <i>Escherichia coli</i>

The <i>Escherichia coli</i> ATP-dependent ClpYQ protease constitutes ClpY ATPase/unfoldase and ClpQ peptidase. The Tyr<sup>91st</sup> residue within the central pore-I site of ClpY-hexamer is important for unfolding and translocating substrates into the catalytic site of ClpQ...

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Bibliographic Details
Main Authors:	Chu-Hsuan Lin, Chih-Hsuan Tsai, Chun-Chi Chou, Whei-Fen Wu
Format:	Article
Language:	English
Published:	MDPI AG 2023-12-01
Series:	International Journal of Molecular Sciences
Subjects:	SulA ClpYQ ATP-dependent protease degron degrader π–π interaction cation–π interaction
Online Access:	https://www.mdpi.com/1422-0067/24/24/17353

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