RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients
The role of innate T cell subsets in the pathogenesis of spondyloarthritis (SpA) is not well understood. Here, the authors examine the role of invariant natural killer T (iNKT) and γδ-T cells in SpA and show that disease-derived iNKT and γδ-T cells have unique and Th17-skewed phenotype and gene expr...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2019-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-07911-6 |
| _version_ | 1819202350025277440 |
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| author | Koen Venken Peggy Jacques Céline Mortier Mark E. Labadia Tine Decruy Julie Coudenys Kathleen Hoyt Anita L. Wayne Robert Hughes Michael Turner Sofie Van Gassen Liesbet Martens Dustin Smith Christian Harcken Joseph Wahle Chao-Ting Wang Eveline Verheugen Nadia Schryvers Gaëlle Varkas Heleen Cypers Ruth Wittoek Yves Piette Lieve Gyselbrecht Serge Van Calenbergh Filip Van den Bosch Yvan Saeys Gerald Nabozny Dirk Elewaut |
| author_facet | Koen Venken Peggy Jacques Céline Mortier Mark E. Labadia Tine Decruy Julie Coudenys Kathleen Hoyt Anita L. Wayne Robert Hughes Michael Turner Sofie Van Gassen Liesbet Martens Dustin Smith Christian Harcken Joseph Wahle Chao-Ting Wang Eveline Verheugen Nadia Schryvers Gaëlle Varkas Heleen Cypers Ruth Wittoek Yves Piette Lieve Gyselbrecht Serge Van Calenbergh Filip Van den Bosch Yvan Saeys Gerald Nabozny Dirk Elewaut |
| author_sort | Koen Venken |
| collection | DOAJ |
| description | The role of innate T cell subsets in the pathogenesis of spondyloarthritis (SpA) is not well understood. Here, the authors examine the role of invariant natural killer T (iNKT) and γδ-T cells in SpA and show that disease-derived iNKT and γδ-T cells have unique and Th17-skewed phenotype and gene expression profiles within inflamed joints. |
| first_indexed | 2024-12-23T04:02:37Z |
| format | Article |
| id | doaj.art-ddd72678135941fdb84362715749b1f1 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-23T04:02:37Z |
| publishDate | 2019-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-ddd72678135941fdb84362715749b1f12022-12-21T18:00:42ZengNature PortfolioNature Communications2041-17232019-01-0110111510.1038/s41467-018-07911-6RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patientsKoen Venken0Peggy Jacques1Céline Mortier2Mark E. Labadia3Tine Decruy4Julie Coudenys5Kathleen Hoyt6Anita L. Wayne7Robert Hughes8Michael Turner9Sofie Van Gassen10Liesbet Martens11Dustin Smith12Christian Harcken13Joseph Wahle14Chao-Ting Wang15Eveline Verheugen16Nadia Schryvers17Gaëlle Varkas18Heleen Cypers19Ruth Wittoek20Yves Piette21Lieve Gyselbrecht22Serge Van Calenbergh23Filip Van den Bosch24Yvan Saeys25Gerald Nabozny26Dirk Elewaut27Department of Rheumatology, Faculty of Medicine and Health Sciences, Laboratory for Molecular Immunology and Inflammation, Ghent UniversityDepartment of Rheumatology, Faculty of Medicine and Health Sciences, Laboratory for Molecular Immunology and Inflammation, Ghent UniversityDepartment of Rheumatology, Faculty of Medicine and Health Sciences, Laboratory for Molecular Immunology and Inflammation, Ghent UniversityResearch and Development Boehringer-IngelheimDepartment of Rheumatology, Faculty of Medicine and Health Sciences, Laboratory for Molecular Immunology and Inflammation, Ghent UniversityDepartment of Rheumatology, Faculty of Medicine and Health Sciences, Laboratory for Molecular Immunology and Inflammation, Ghent UniversityResearch and Development Boehringer-IngelheimResearch and Development Boehringer-IngelheimResearch and Development Boehringer-IngelheimResearch and Development Boehringer-IngelheimVIB Inflammation Research Center, Ghent UniversityVIB Inflammation Research Center, Ghent UniversityResearch and Development Boehringer-IngelheimResearch and Development Boehringer-IngelheimResearch and Development Boehringer-IngelheimResearch and Development Boehringer-IngelheimDepartment of Rheumatology, Faculty of Medicine and Health Sciences, Laboratory for Molecular Immunology and Inflammation, Ghent UniversityDepartment of Rheumatology, Faculty of Medicine and Health Sciences, Laboratory for Molecular Immunology and Inflammation, Ghent UniversityDepartment of Rheumatology, Faculty of Medicine and Health Sciences, Laboratory for Molecular Immunology and Inflammation, Ghent UniversityDepartment of Rheumatology, Faculty of Medicine and Health Sciences, Laboratory for Molecular Immunology and Inflammation, Ghent UniversityDepartment of Rheumatology, Faculty of Medicine and Health Sciences, Laboratory for Molecular Immunology and Inflammation, Ghent UniversityDepartment of Rheumatology, Faculty of Medicine and Health Sciences, Laboratory for Molecular Immunology and Inflammation, Ghent UniversityASZ AalstLaboratory for Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Ghent UniversityDepartment of Rheumatology, Faculty of Medicine and Health Sciences, Laboratory for Molecular Immunology and Inflammation, Ghent UniversityVIB Inflammation Research Center, Ghent UniversityResearch and Development Boehringer-IngelheimDepartment of Rheumatology, Faculty of Medicine and Health Sciences, Laboratory for Molecular Immunology and Inflammation, Ghent UniversityThe role of innate T cell subsets in the pathogenesis of spondyloarthritis (SpA) is not well understood. Here, the authors examine the role of invariant natural killer T (iNKT) and γδ-T cells in SpA and show that disease-derived iNKT and γδ-T cells have unique and Th17-skewed phenotype and gene expression profiles within inflamed joints.https://doi.org/10.1038/s41467-018-07911-6 |
| spellingShingle | Koen Venken Peggy Jacques Céline Mortier Mark E. Labadia Tine Decruy Julie Coudenys Kathleen Hoyt Anita L. Wayne Robert Hughes Michael Turner Sofie Van Gassen Liesbet Martens Dustin Smith Christian Harcken Joseph Wahle Chao-Ting Wang Eveline Verheugen Nadia Schryvers Gaëlle Varkas Heleen Cypers Ruth Wittoek Yves Piette Lieve Gyselbrecht Serge Van Calenbergh Filip Van den Bosch Yvan Saeys Gerald Nabozny Dirk Elewaut RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients Nature Communications |
| title | RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients |
| title_full | RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients |
| title_fullStr | RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients |
| title_full_unstemmed | RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients |
| title_short | RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients |
| title_sort | rorγt inhibition selectively targets il 17 producing inkt and γδ t cells enriched in spondyloarthritis patients |
| url | https://doi.org/10.1038/s41467-018-07911-6 |
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