Development and Effects of Influenza Antiviral Drugs
Influenza virus is a highly contagious zoonotic respiratory disease that causes seasonal outbreaks each year and unpredictable pandemics occasionally with high morbidity and mortality rates, posing a great threat to public health worldwide. Besides the limited effect of vaccines, the problem is exac...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/4/810 |
| _version_ | 1797415061367554048 |
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| author | Hang Yin Ning Jiang Wenhao Shi Xiaojuan Chi Sairu Liu Ji-Long Chen Song Wang |
| author_facet | Hang Yin Ning Jiang Wenhao Shi Xiaojuan Chi Sairu Liu Ji-Long Chen Song Wang |
| author_sort | Hang Yin |
| collection | DOAJ |
| description | Influenza virus is a highly contagious zoonotic respiratory disease that causes seasonal outbreaks each year and unpredictable pandemics occasionally with high morbidity and mortality rates, posing a great threat to public health worldwide. Besides the limited effect of vaccines, the problem is exacerbated by the lack of drugs with strong antiviral activity against all flu strains. Currently, there are two classes of antiviral drugs available that are chemosynthetic and approved against influenza A virus for prophylactic and therapeutic treatment, but the appearance of drug-resistant virus strains is a serious issue that strikes at the core of influenza control. There is therefore an urgent need to develop new antiviral drugs. Many reports have shown that the development of novel bioactive plant extracts and microbial extracts has significant advantages in influenza treatment. This paper comprehensively reviews the development and effects of chemosynthetic drugs, plant extracts, and microbial extracts with influenza antiviral activity, hoping to provide some references for novel antiviral drug design and promising alternative candidates for further anti-influenza drug development. |
| first_indexed | 2024-03-09T05:43:37Z |
| format | Article |
| id | doaj.art-ddda2f258e434dd3b02441448a96b775 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T05:43:37Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-ddda2f258e434dd3b02441448a96b7752023-12-03T12:23:32ZengMDPI AGMolecules1420-30492021-02-0126481010.3390/molecules26040810Development and Effects of Influenza Antiviral DrugsHang Yin0Ning Jiang1Wenhao Shi2Xiaojuan Chi3Sairu Liu4Ji-Long Chen5Song Wang6Key Laboratory of Fujian-Taiwan Animal Pathogen Biology, College of Animal Sciences (College of Bee Science), Fujian Agriculture and Forestry University, Fuzhou 350002, ChinaKey Laboratory of Fujian-Taiwan Animal Pathogen Biology, College of Animal Sciences (College of Bee Science), Fujian Agriculture and Forestry University, Fuzhou 350002, ChinaKey Laboratory of Fujian-Taiwan Animal Pathogen Biology, College of Animal Sciences (College of Bee Science), Fujian Agriculture and Forestry University, Fuzhou 350002, ChinaKey Laboratory of Fujian-Taiwan Animal Pathogen Biology, College of Animal Sciences (College of Bee Science), Fujian Agriculture and Forestry University, Fuzhou 350002, ChinaKey Laboratory of Fujian-Taiwan Animal Pathogen Biology, College of Animal Sciences (College of Bee Science), Fujian Agriculture and Forestry University, Fuzhou 350002, ChinaKey Laboratory of Fujian-Taiwan Animal Pathogen Biology, College of Animal Sciences (College of Bee Science), Fujian Agriculture and Forestry University, Fuzhou 350002, ChinaKey Laboratory of Fujian-Taiwan Animal Pathogen Biology, College of Animal Sciences (College of Bee Science), Fujian Agriculture and Forestry University, Fuzhou 350002, ChinaInfluenza virus is a highly contagious zoonotic respiratory disease that causes seasonal outbreaks each year and unpredictable pandemics occasionally with high morbidity and mortality rates, posing a great threat to public health worldwide. Besides the limited effect of vaccines, the problem is exacerbated by the lack of drugs with strong antiviral activity against all flu strains. Currently, there are two classes of antiviral drugs available that are chemosynthetic and approved against influenza A virus for prophylactic and therapeutic treatment, but the appearance of drug-resistant virus strains is a serious issue that strikes at the core of influenza control. There is therefore an urgent need to develop new antiviral drugs. Many reports have shown that the development of novel bioactive plant extracts and microbial extracts has significant advantages in influenza treatment. This paper comprehensively reviews the development and effects of chemosynthetic drugs, plant extracts, and microbial extracts with influenza antiviral activity, hoping to provide some references for novel antiviral drug design and promising alternative candidates for further anti-influenza drug development.https://www.mdpi.com/1420-3049/26/4/810influenza viruschemosynthetic drugsplant extractsmicrobial metabolitesdrug resistance |
| spellingShingle | Hang Yin Ning Jiang Wenhao Shi Xiaojuan Chi Sairu Liu Ji-Long Chen Song Wang Development and Effects of Influenza Antiviral Drugs Molecules influenza virus chemosynthetic drugs plant extracts microbial metabolites drug resistance |
| title | Development and Effects of Influenza Antiviral Drugs |
| title_full | Development and Effects of Influenza Antiviral Drugs |
| title_fullStr | Development and Effects of Influenza Antiviral Drugs |
| title_full_unstemmed | Development and Effects of Influenza Antiviral Drugs |
| title_short | Development and Effects of Influenza Antiviral Drugs |
| title_sort | development and effects of influenza antiviral drugs |
| topic | influenza virus chemosynthetic drugs plant extracts microbial metabolites drug resistance |
| url | https://www.mdpi.com/1420-3049/26/4/810 |
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