Analysis of adaptation mutants in the hemagglutinin of the influenza A(H1N1)pdm09 virus.
Hemagglutinin is the major surface glycoprotein of influenza viruses. It participates in the initial steps of viral infection through receptor binding and membrane fusion events. The influenza pandemic of 2009 provided a unique scenario to study virus evolution. We performed molecular dynamics simul...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3720954?pdf=render |
| _version_ | 1811271872864583680 |
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| author | Alicia Jiménez-Alberto Esmeralda Alvarado-Facundo Rosa María Ribas-Aparicio Juan A Castelán-Vega |
| author_facet | Alicia Jiménez-Alberto Esmeralda Alvarado-Facundo Rosa María Ribas-Aparicio Juan A Castelán-Vega |
| author_sort | Alicia Jiménez-Alberto |
| collection | DOAJ |
| description | Hemagglutinin is the major surface glycoprotein of influenza viruses. It participates in the initial steps of viral infection through receptor binding and membrane fusion events. The influenza pandemic of 2009 provided a unique scenario to study virus evolution. We performed molecular dynamics simulations with four hemagglutinin variants that appeared throughout the 2009 influenza A (H1N1) pandemic. We found that variant 1 (S143G, S185T) likely arose to avoid immune recognition. Variant 2 (A134T), and variant 3 (D222E, P297S) had an increased binding affinity for the receptor. Finally, variant 4 (E374K) altered hemagglutinin stability in the vicinity of the fusion peptide. Variants 1 and 4 have become increasingly predominant, while variants 2 and 3 declined as the pandemic progressed. Our results show some of the different strategies that the influenza virus uses to adapt to the human host and provide an example of how selective pressure drives antigenic drift in viral proteins. |
| first_indexed | 2024-04-12T22:30:00Z |
| format | Article |
| id | doaj.art-dddc816bc7f0446c91f14a30790f59e0 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T22:30:00Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-dddc816bc7f0446c91f14a30790f59e02022-12-22T03:14:01ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0187e7000510.1371/journal.pone.0070005Analysis of adaptation mutants in the hemagglutinin of the influenza A(H1N1)pdm09 virus.Alicia Jiménez-AlbertoEsmeralda Alvarado-FacundoRosa María Ribas-AparicioJuan A Castelán-VegaHemagglutinin is the major surface glycoprotein of influenza viruses. It participates in the initial steps of viral infection through receptor binding and membrane fusion events. The influenza pandemic of 2009 provided a unique scenario to study virus evolution. We performed molecular dynamics simulations with four hemagglutinin variants that appeared throughout the 2009 influenza A (H1N1) pandemic. We found that variant 1 (S143G, S185T) likely arose to avoid immune recognition. Variant 2 (A134T), and variant 3 (D222E, P297S) had an increased binding affinity for the receptor. Finally, variant 4 (E374K) altered hemagglutinin stability in the vicinity of the fusion peptide. Variants 1 and 4 have become increasingly predominant, while variants 2 and 3 declined as the pandemic progressed. Our results show some of the different strategies that the influenza virus uses to adapt to the human host and provide an example of how selective pressure drives antigenic drift in viral proteins.http://europepmc.org/articles/PMC3720954?pdf=render |
| spellingShingle | Alicia Jiménez-Alberto Esmeralda Alvarado-Facundo Rosa María Ribas-Aparicio Juan A Castelán-Vega Analysis of adaptation mutants in the hemagglutinin of the influenza A(H1N1)pdm09 virus. PLoS ONE |
| title | Analysis of adaptation mutants in the hemagglutinin of the influenza A(H1N1)pdm09 virus. |
| title_full | Analysis of adaptation mutants in the hemagglutinin of the influenza A(H1N1)pdm09 virus. |
| title_fullStr | Analysis of adaptation mutants in the hemagglutinin of the influenza A(H1N1)pdm09 virus. |
| title_full_unstemmed | Analysis of adaptation mutants in the hemagglutinin of the influenza A(H1N1)pdm09 virus. |
| title_short | Analysis of adaptation mutants in the hemagglutinin of the influenza A(H1N1)pdm09 virus. |
| title_sort | analysis of adaptation mutants in the hemagglutinin of the influenza a h1n1 pdm09 virus |
| url | http://europepmc.org/articles/PMC3720954?pdf=render |
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