Rhesus-D zygosity and hemolytic disease of fetus and newborn
Alloimmunization against the Rhesus-D (RhD) antigen still remains as a major cause of hemolytic disease of fetus and newborn (HDFN). Determination of paternal RhDzygosity is performed by molecular testing and is valuable for the management of alloimmunized pregnant women. A 30-year-old pregnant woma...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2013-01-01
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| Series: | Asian Journal of Transfusion Science |
| Subjects: | |
| Online Access: | http://www.ajts.org/article.asp?issn=0973-6247;year=2013;volume=7;issue=2;spage=156;epage=157;aulast=Moghaddam |
| _version_ | 1819058082106310656 |
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| author | Mostafa Moghaddam Amirali Naghi Fatemeh Hassani Sedighe Amini |
| author_facet | Mostafa Moghaddam Amirali Naghi Fatemeh Hassani Sedighe Amini |
| author_sort | Mostafa Moghaddam |
| collection | DOAJ |
| description | Alloimmunization against the Rhesus-D (RhD) antigen still remains as a major cause of hemolytic disease of fetus and newborn (HDFN). Determination of paternal RhDzygosity is performed by molecular testing and is valuable for the management of alloimmunized pregnant women. A 30-year-old pregnant woman with AB negative blood group presented with two consecutive abortions and no history of blood transfusion. By application of the antibody screening, identification panel, and selected cells, she was found to be highly alloimmunized. RhDzygosity was performed on her partner and was shown to be homozygous for RhD. The sequence- specific priming-polymerase chain reaction used in this report is essential to establish whether the mother requires an appropriate immunoprophylaxis or the fetus is at risk of HDFN. |
| first_indexed | 2024-12-21T13:49:32Z |
| format | Article |
| id | doaj.art-dde15961bba24bb8ae87935fe7e3599f |
| institution | Directory Open Access Journal |
| issn | 0973-6247 1998-3565 |
| language | English |
| last_indexed | 2024-12-21T13:49:32Z |
| publishDate | 2013-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Journal of Transfusion Science |
| spelling | doaj.art-dde15961bba24bb8ae87935fe7e3599f2022-12-21T19:01:45ZengWolters Kluwer Medknow PublicationsAsian Journal of Transfusion Science0973-62471998-35652013-01-017215615710.4103/0973-6247.115584Rhesus-D zygosity and hemolytic disease of fetus and newbornMostafa MoghaddamAmirali NaghiFatemeh HassaniSedighe AminiAlloimmunization against the Rhesus-D (RhD) antigen still remains as a major cause of hemolytic disease of fetus and newborn (HDFN). Determination of paternal RhDzygosity is performed by molecular testing and is valuable for the management of alloimmunized pregnant women. A 30-year-old pregnant woman with AB negative blood group presented with two consecutive abortions and no history of blood transfusion. By application of the antibody screening, identification panel, and selected cells, she was found to be highly alloimmunized. RhDzygosity was performed on her partner and was shown to be homozygous for RhD. The sequence- specific priming-polymerase chain reaction used in this report is essential to establish whether the mother requires an appropriate immunoprophylaxis or the fetus is at risk of HDFN.http://www.ajts.org/article.asp?issn=0973-6247;year=2013;volume=7;issue=2;spage=156;epage=157;aulast=MoghaddamRhesus-Dzygosityhemolytic disease of fetus and newbornanti-D |
| spellingShingle | Mostafa Moghaddam Amirali Naghi Fatemeh Hassani Sedighe Amini Rhesus-D zygosity and hemolytic disease of fetus and newborn Asian Journal of Transfusion Science Rhesus-Dzygosity hemolytic disease of fetus and newborn anti-D |
| title | Rhesus-D zygosity and hemolytic disease of fetus and newborn |
| title_full | Rhesus-D zygosity and hemolytic disease of fetus and newborn |
| title_fullStr | Rhesus-D zygosity and hemolytic disease of fetus and newborn |
| title_full_unstemmed | Rhesus-D zygosity and hemolytic disease of fetus and newborn |
| title_short | Rhesus-D zygosity and hemolytic disease of fetus and newborn |
| title_sort | rhesus d zygosity and hemolytic disease of fetus and newborn |
| topic | Rhesus-Dzygosity hemolytic disease of fetus and newborn anti-D |
| url | http://www.ajts.org/article.asp?issn=0973-6247;year=2013;volume=7;issue=2;spage=156;epage=157;aulast=Moghaddam |
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