5′-Isoforms of miR-1246 Have Distinct Targets and Stronger Functional Impact Compared with Canonical miR-1246 in Colorectal Cancer Cells In Vitro

5′-Isoforms of miR-1246 Have Distinct Targets and Stronger Functional Impact Compared with Canonical miR-1246 in Colorectal Cancer Cells In Vitro

Colorectal cancer (CRC) is a multifactorial disease involving genetic and epigenetic factors, such as miRNAs. Sequencing-based studies have revealed that miRNAs have many isoforms (isomiRs) with modifications at the 3′- and 5′-ends or in the middle, resulting in distinct targetomes and, consequently...

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Bibliographic Details
Main Authors: Rokas Lukosevicius, Gediminas Alzbutas, Greta Varkalaite, Violeta Salteniene, Deimante Tilinde, Simonas Juzenas, Ugne Kulokiene, Dainius Janciauskas, Lina Poskiene, Kestutis Adamonis, Gediminas Kiudelis, Juozas Kupcinskas, Jurgita Skieceviciene
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:International Journal of Molecular Sciences
Subjects:
CRC
miR-1246
5′-isomiRs
targetome
5′-isomiR functions in vitro
Online Access:https://www.mdpi.com/1422-0067/25/5/2808

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