Longitudinal NGAL and cystatin C plasma profiles present a high level of heterogeneity in a mixed ICU population
Abstract Background NGAL and Cystatin C (CysC) as biomarkers for the early detection of AKI are subject to both pathophysiological, as well as patient related heterogeneity. The aim of this study was to investigate the timeline of plasma levels of NGAL and CysC during the first seven days of ICU adm...
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | BMC Nephrology |
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| Online Access: | https://doi.org/10.1186/s12882-024-03477-2 |
| _version_ | 1797275580086878208 |
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| author | Daniela Jou-Valencia Meint Volbeda Jan G. Zijlstra Jenny E Kootstra-Ros Jill Moser Matijs van Meurs Jacqueline Koeze |
| author_facet | Daniela Jou-Valencia Meint Volbeda Jan G. Zijlstra Jenny E Kootstra-Ros Jill Moser Matijs van Meurs Jacqueline Koeze |
| author_sort | Daniela Jou-Valencia |
| collection | DOAJ |
| description | Abstract Background NGAL and Cystatin C (CysC) as biomarkers for the early detection of AKI are subject to both pathophysiological, as well as patient related heterogeneity. The aim of this study was to investigate the timeline of plasma levels of NGAL and CysC during the first seven days of ICU admission in a mixed ICU population and to relate these to AKI severity during ICU stay. Via these means we aimed to bring clarity to the previously reported heterogeneity of these renal biomarkers. Methods Prospective Observation Cohort. Consecutive patients admitted to adult ICU at an academic hospital in the Netherlands between 18-02-2014 and 31-03-2014 were included. Urine output, serum creatinine, plasma NGAL and CysC were recorded during the first seven days of ICU admission. Biomarker expression was analyzed based on KDIGO score and time of AKI diagnosis. Results 335 patients were included, 110 met KDIGO criteria for AKI. NGAL and CysC plasma levels were higher in AKI patients compared to non-AKI, high variability in individual values resulted in 56% of AKI patients having a false negative, and 32% of non-AKI patients having a false positive. Individual biomarker levels were variable, and no pattern based on KDIGO score was observed. Conclusions Plasma NGAL and CysC as biomarkers for the early AKI detection may be subject to pathophysiological, and patient related heterogeneity. Further understanding of individual biomarker profiles may help in their application amongst mixed ICU populations. Trial Registration The need for informed consent was waived by the Institutional Ethical Review Board of the University Medical Center Groningen (METc 2013 − 174) by Prof. dr. W.A. Kamps on May 17th 2013. |
| first_indexed | 2024-03-07T15:15:33Z |
| format | Article |
| id | doaj.art-dde485fb152b4233821504529e779bfa |
| institution | Directory Open Access Journal |
| issn | 1471-2369 |
| language | English |
| last_indexed | 2024-03-07T15:15:33Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj.art-dde485fb152b4233821504529e779bfa2024-03-05T17:57:13ZengBMCBMC Nephrology1471-23692024-01-0125111010.1186/s12882-024-03477-2Longitudinal NGAL and cystatin C plasma profiles present a high level of heterogeneity in a mixed ICU populationDaniela Jou-Valencia0Meint Volbeda1Jan G. Zijlstra2Jenny E Kootstra-Ros3Jill Moser4Matijs van Meurs5Jacqueline Koeze6Department of Critical Care, University of Groningen, University Medical Center Groningen (UMCG)Department of Critical Care, University of Groningen, University Medical Center Groningen (UMCG)Department of Critical Care, University of Groningen, University Medical Center Groningen (UMCG)Department of Laboratory Medicine, UMCGDepartment of Critical Care, University of Groningen, University Medical Center Groningen (UMCG)Department of Critical Care, University of Groningen, University Medical Center Groningen (UMCG)Department of Critical Care, University of Groningen, University Medical Center Groningen (UMCG)Abstract Background NGAL and Cystatin C (CysC) as biomarkers for the early detection of AKI are subject to both pathophysiological, as well as patient related heterogeneity. The aim of this study was to investigate the timeline of plasma levels of NGAL and CysC during the first seven days of ICU admission in a mixed ICU population and to relate these to AKI severity during ICU stay. Via these means we aimed to bring clarity to the previously reported heterogeneity of these renal biomarkers. Methods Prospective Observation Cohort. Consecutive patients admitted to adult ICU at an academic hospital in the Netherlands between 18-02-2014 and 31-03-2014 were included. Urine output, serum creatinine, plasma NGAL and CysC were recorded during the first seven days of ICU admission. Biomarker expression was analyzed based on KDIGO score and time of AKI diagnosis. Results 335 patients were included, 110 met KDIGO criteria for AKI. NGAL and CysC plasma levels were higher in AKI patients compared to non-AKI, high variability in individual values resulted in 56% of AKI patients having a false negative, and 32% of non-AKI patients having a false positive. Individual biomarker levels were variable, and no pattern based on KDIGO score was observed. Conclusions Plasma NGAL and CysC as biomarkers for the early AKI detection may be subject to pathophysiological, and patient related heterogeneity. Further understanding of individual biomarker profiles may help in their application amongst mixed ICU populations. Trial Registration The need for informed consent was waived by the Institutional Ethical Review Board of the University Medical Center Groningen (METc 2013 − 174) by Prof. dr. W.A. Kamps on May 17th 2013.https://doi.org/10.1186/s12882-024-03477-2Cystatin CNGALHeterogeneityAKITimeline |
| spellingShingle | Daniela Jou-Valencia Meint Volbeda Jan G. Zijlstra Jenny E Kootstra-Ros Jill Moser Matijs van Meurs Jacqueline Koeze Longitudinal NGAL and cystatin C plasma profiles present a high level of heterogeneity in a mixed ICU population BMC Nephrology Cystatin C NGAL Heterogeneity AKI Timeline |
| title | Longitudinal NGAL and cystatin C plasma profiles present a high level of heterogeneity in a mixed ICU population |
| title_full | Longitudinal NGAL and cystatin C plasma profiles present a high level of heterogeneity in a mixed ICU population |
| title_fullStr | Longitudinal NGAL and cystatin C plasma profiles present a high level of heterogeneity in a mixed ICU population |
| title_full_unstemmed | Longitudinal NGAL and cystatin C plasma profiles present a high level of heterogeneity in a mixed ICU population |
| title_short | Longitudinal NGAL and cystatin C plasma profiles present a high level of heterogeneity in a mixed ICU population |
| title_sort | longitudinal ngal and cystatin c plasma profiles present a high level of heterogeneity in a mixed icu population |
| topic | Cystatin C NGAL Heterogeneity AKI Timeline |
| url | https://doi.org/10.1186/s12882-024-03477-2 |
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