SARS-COV-2: more than a respiratory virus
Background: the SARS-CoV-2 virus is responsible for the second pandemic of the 21st century. Since its appearance in China at the end of 2019, it has been associated with pneumonia and considered to be just another respiratory virus. However, during its global spread, it shows its ability to damage...
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| Format: | Article |
| Language: | Spanish |
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Universidad de Ciencias Médicas de Camagüey
2021-03-01
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| Series: | Archivo Médico de Camagüey |
| Subjects: | |
| Online Access: | http://www.revistaamc.sld.cu/index.php/amc/article/view/8018 |
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| author | Franklin Rómulo Aguilar-Gamboa Jorge Arturo Vega-Fernández Danny Omar Suclupe-Campos |
| author_facet | Franklin Rómulo Aguilar-Gamboa Jorge Arturo Vega-Fernández Danny Omar Suclupe-Campos |
| author_sort | Franklin Rómulo Aguilar-Gamboa |
| collection | DOAJ |
| description | Background: the SARS-CoV-2 virus is responsible for the second pandemic of the 21st century. Since its appearance in China at the end of 2019, it has been associated with pneumonia and considered to be just another respiratory virus. However, during its global spread, it shows its ability to damage other organs with clinical manifestations never before described for other respiratory viruses.
Objective: to describe the scientific evidence that supports the direct extra-pulmonary damage produced by the SARS-CoV-2 virus in late stages of infection, which supports its biphasic nature and different from other respiratory viruses.
Methods: a search of the articles was carried out in the MEDLINE databases accessed from PubMed, SciELO and LILACS. Articles published in prepress repositories such as medRxiv, BioRxiv were also taken into account. Using the Mendeley reference manager and search manager, duplicates and those that did not meet the objective of the study were eliminated, selecting 63 articles for the present review.
Results: the evidence suggests that SARS-CoV-2 has a tropism not only limited to the respiratory tract. The clinical progression of COVID-19 presents a biphasic course, with flu-like manifestations in the first phase and post-acute and persistent episodes in the late phase, caused by direct damage to the central nervous, cardiovascular, endocrine and renal systems.
Conclusions: SARS-CoV-2 infection should not be considered only as an acute infection limited to the respiratory tract.
DeCS: SARS VIRUS/pathogenicity; CORONAVIRUS INFECTIONS/transmission; RESPIRATORY TRACT INFECTIONS/prevention & control; VIRAL TROPISM/physiology; VIRUS REPLICATION. |
| first_indexed | 2024-12-16T14:13:37Z |
| format | Article |
| id | doaj.art-dde837455bb04a39a6dd1fb80bdb8507 |
| institution | Directory Open Access Journal |
| issn | 1025-0255 |
| language | Spanish |
| last_indexed | 2024-12-16T14:13:37Z |
| publishDate | 2021-03-01 |
| publisher | Universidad de Ciencias Médicas de Camagüey |
| record_format | Article |
| series | Archivo Médico de Camagüey |
| spelling | doaj.art-dde837455bb04a39a6dd1fb80bdb85072022-12-21T22:28:41ZspaUniversidad de Ciencias Médicas de CamagüeyArchivo Médico de Camagüey1025-02552021-03-012522993152384SARS-COV-2: more than a respiratory virusFranklin Rómulo Aguilar-Gamboa0Jorge Arturo Vega-FernándezDanny Omar Suclupe-CamposHOSPITAL REGIONAL LAMBAYEQUEBackground: the SARS-CoV-2 virus is responsible for the second pandemic of the 21st century. Since its appearance in China at the end of 2019, it has been associated with pneumonia and considered to be just another respiratory virus. However, during its global spread, it shows its ability to damage other organs with clinical manifestations never before described for other respiratory viruses. Objective: to describe the scientific evidence that supports the direct extra-pulmonary damage produced by the SARS-CoV-2 virus in late stages of infection, which supports its biphasic nature and different from other respiratory viruses. Methods: a search of the articles was carried out in the MEDLINE databases accessed from PubMed, SciELO and LILACS. Articles published in prepress repositories such as medRxiv, BioRxiv were also taken into account. Using the Mendeley reference manager and search manager, duplicates and those that did not meet the objective of the study were eliminated, selecting 63 articles for the present review. Results: the evidence suggests that SARS-CoV-2 has a tropism not only limited to the respiratory tract. The clinical progression of COVID-19 presents a biphasic course, with flu-like manifestations in the first phase and post-acute and persistent episodes in the late phase, caused by direct damage to the central nervous, cardiovascular, endocrine and renal systems. Conclusions: SARS-CoV-2 infection should not be considered only as an acute infection limited to the respiratory tract. DeCS: SARS VIRUS/pathogenicity; CORONAVIRUS INFECTIONS/transmission; RESPIRATORY TRACT INFECTIONS/prevention & control; VIRAL TROPISM/physiology; VIRUS REPLICATION.http://www.revistaamc.sld.cu/index.php/amc/article/view/8018coronavirus, covid-19, sars-cov-2, fisiopatología, manifestaciones neurológicas, enfermedades cardiovasculares, |
| spellingShingle | Franklin Rómulo Aguilar-Gamboa Jorge Arturo Vega-Fernández Danny Omar Suclupe-Campos SARS-COV-2: more than a respiratory virus Archivo Médico de Camagüey coronavirus, covid-19, sars-cov-2, fisiopatología, manifestaciones neurológicas, enfermedades cardiovasculares, |
| title | SARS-COV-2: more than a respiratory virus |
| title_full | SARS-COV-2: more than a respiratory virus |
| title_fullStr | SARS-COV-2: more than a respiratory virus |
| title_full_unstemmed | SARS-COV-2: more than a respiratory virus |
| title_short | SARS-COV-2: more than a respiratory virus |
| title_sort | sars cov 2 more than a respiratory virus |
| topic | coronavirus, covid-19, sars-cov-2, fisiopatología, manifestaciones neurológicas, enfermedades cardiovasculares, |
| url | http://www.revistaamc.sld.cu/index.php/amc/article/view/8018 |
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