Mitochondrial iron overload mediated by cooperative transfer of plasma membrane ATP5B and TFR2 to mitochondria triggers hepatic insulin resistance under PFOS exposure

Mitochondrial iron overload mediated by cooperative transfer of plasma membrane ATP5B and TFR2 to mitochondria triggers hepatic insulin resistance under PFOS exposure

In general populations, insulin resistance (IR) is related to perfluorooctane sulfonate (PFOS), a persistent organic pollutant. However, the underlying mechanism remains unclear. In this study, PFOS induced mitochondrial iron accumulation in the liver of mice and human hepatocytes L-O2. In the PFOS-...

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Bibliographic Details
Main Authors: Jianyu Wang, Jinling Wang, Tianming Qiu, Jialu Wu, Xiance Sun, Liping Jiang, Xiaofang Liu, Guang Yang, Jun Cao, Xiaofeng Yao
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Perfluorooctane sulphonate
Mitochondrial iron
Ectopic ATP synthase
Transferrin receptor 2
Insulin resistance
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651323001665

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http://www.sciencedirect.com/science/article/pii/S0147651323001665

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