Mitochondrial iron overload mediated by cooperative transfer of plasma membrane ATP5B and TFR2 to mitochondria triggers hepatic insulin resistance under PFOS exposure
In general populations, insulin resistance (IR) is related to perfluorooctane sulfonate (PFOS), a persistent organic pollutant. However, the underlying mechanism remains unclear. In this study, PFOS induced mitochondrial iron accumulation in the liver of mice and human hepatocytes L-O2. In the PFOS-...
Main Authors: | Jianyu Wang, Jinling Wang, Tianming Qiu, Jialu Wu, Xiance Sun, Liping Jiang, Xiaofang Liu, Guang Yang, Jun Cao, Xiaofeng Yao |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2023-03-01
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Series: | Ecotoxicology and Environmental Safety |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651323001665 |
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