Primary malignant melanoma of the female urethra: A case report

Primary malignant melanoma of a female urethra is extremely rare. A 71-year-old female was referred to our hospital with bleeding from the urethral meatus. Magnetic resonance imaging revealed a mass of 25 mm in diameter at the external urethral meatus. She underwent anterior pelvic exenteration and...

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Main Authors: Kazuhiro Watanabe, Go Hasegawa, Katsunori Kashima, Yo Sato, Noboru Hara, Tsutomu Nishiyama
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Urology Case Reports
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S221444202030382X
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author Kazuhiro Watanabe
Go Hasegawa
Katsunori Kashima
Yo Sato
Noboru Hara
Tsutomu Nishiyama
author_facet Kazuhiro Watanabe
Go Hasegawa
Katsunori Kashima
Yo Sato
Noboru Hara
Tsutomu Nishiyama
author_sort Kazuhiro Watanabe
collection DOAJ
description Primary malignant melanoma of a female urethra is extremely rare. A 71-year-old female was referred to our hospital with bleeding from the urethral meatus. Magnetic resonance imaging revealed a mass of 25 mm in diameter at the external urethral meatus. She underwent anterior pelvic exenteration and ileal conduit diversion. Histopathological findings were urethral malignant melanoma, pT3apN0M0 (stage IIA). Nine months after surgery, computed tomography revealed a local recurrence in the pelvis, the patient was treated with immunotherapy using combined nivolumab and ipilimumab; however, she did not respond to treatment and died 22 months following diagnosis.
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spelling doaj.art-ddeae4f249d74b85b7f2cdbc249d3b552022-12-21T21:33:20ZengElsevierUrology Case Reports2214-44202021-01-0134101493Primary malignant melanoma of the female urethra: A case reportKazuhiro Watanabe0Go Hasegawa1Katsunori Kashima2Yo Sato3Noboru Hara4Tsutomu Nishiyama5Department of Urology, JapanDepartment of Pathology, JapanDepartment of Gynecology, JapanDepartment of General Surgery, Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital, Minamiuonuma, Niigata, JapanDepartment of Urology, JapanDepartment of Urology, Japan; Corresponding author. Department of Urology, Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital, Urasa 4132, Minamiuonumashi, 949Niigata, Japan.Primary malignant melanoma of a female urethra is extremely rare. A 71-year-old female was referred to our hospital with bleeding from the urethral meatus. Magnetic resonance imaging revealed a mass of 25 mm in diameter at the external urethral meatus. She underwent anterior pelvic exenteration and ileal conduit diversion. Histopathological findings were urethral malignant melanoma, pT3apN0M0 (stage IIA). Nine months after surgery, computed tomography revealed a local recurrence in the pelvis, the patient was treated with immunotherapy using combined nivolumab and ipilimumab; however, she did not respond to treatment and died 22 months following diagnosis.http://www.sciencedirect.com/science/article/pii/S221444202030382XMalignant melanomaUrethraAnterior pelvic exenterationImmuno-oncology therapy
spellingShingle Kazuhiro Watanabe
Go Hasegawa
Katsunori Kashima
Yo Sato
Noboru Hara
Tsutomu Nishiyama
Primary malignant melanoma of the female urethra: A case report
Urology Case Reports
Malignant melanoma
Urethra
Anterior pelvic exenteration
Immuno-oncology therapy
title Primary malignant melanoma of the female urethra: A case report
title_full Primary malignant melanoma of the female urethra: A case report
title_fullStr Primary malignant melanoma of the female urethra: A case report
title_full_unstemmed Primary malignant melanoma of the female urethra: A case report
title_short Primary malignant melanoma of the female urethra: A case report
title_sort primary malignant melanoma of the female urethra a case report
topic Malignant melanoma
Urethra
Anterior pelvic exenteration
Immuno-oncology therapy
url http://www.sciencedirect.com/science/article/pii/S221444202030382X
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