Anatomical and functional organization of the human substantia nigra and its connections
We investigated the anatomical and functional organization of the human substantia nigra (SN) using diffusion and functional MRI data from the Human Connectome Project. We identified a tripartite connectivity-based parcellation of SN with a limbic, cognitive, motor arrangement. The medial SN connect...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2017-08-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/26653 |
| _version_ | 1811236905321234432 |
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| author | Yu Zhang Kevin Michel-Herve Larcher Bratislav Misic Alain Dagher |
| author_facet | Yu Zhang Kevin Michel-Herve Larcher Bratislav Misic Alain Dagher |
| author_sort | Yu Zhang |
| collection | DOAJ |
| description | We investigated the anatomical and functional organization of the human substantia nigra (SN) using diffusion and functional MRI data from the Human Connectome Project. We identified a tripartite connectivity-based parcellation of SN with a limbic, cognitive, motor arrangement. The medial SN connects with limbic striatal and cortical regions and encodes value (greater response to monetary wins than losses during fMRI), while the ventral SN connects with associative regions of cortex and striatum and encodes salience (equal response to wins and losses). The lateral SN connects with somatomotor regions of striatum and cortex and also encodes salience. Behavioral measures from delay discounting and flanker tasks supported a role for the value-coding medial SN network in decisional impulsivity, while the salience-coding ventral SN network was associated with motor impulsivity. In sum, there is anatomical and functional heterogeneity of human SN, which underpins value versus salience coding, and impulsive choice versus impulsive action. |
| first_indexed | 2024-04-12T12:16:07Z |
| format | Article |
| id | doaj.art-ddeb69f4c12c49f5b9c15be05cb2b148 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T12:16:07Z |
| publishDate | 2017-08-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-ddeb69f4c12c49f5b9c15be05cb2b1482022-12-22T03:33:25ZengeLife Sciences Publications LtdeLife2050-084X2017-08-01610.7554/eLife.26653Anatomical and functional organization of the human substantia nigra and its connectionsYu Zhang0Kevin Michel-Herve Larcher1Bratislav Misic2Alain Dagher3https://orcid.org/0000-0002-0945-5779Montreal Neurological Institute, McGill University, Montreal, CanadaMontreal Neurological Institute, McGill University, Montreal, CanadaMontreal Neurological Institute, McGill University, Montreal, CanadaMontreal Neurological Institute, McGill University, Montreal, CanadaWe investigated the anatomical and functional organization of the human substantia nigra (SN) using diffusion and functional MRI data from the Human Connectome Project. We identified a tripartite connectivity-based parcellation of SN with a limbic, cognitive, motor arrangement. The medial SN connects with limbic striatal and cortical regions and encodes value (greater response to monetary wins than losses during fMRI), while the ventral SN connects with associative regions of cortex and striatum and encodes salience (equal response to wins and losses). The lateral SN connects with somatomotor regions of striatum and cortex and also encodes salience. Behavioral measures from delay discounting and flanker tasks supported a role for the value-coding medial SN network in decisional impulsivity, while the salience-coding ventral SN network was associated with motor impulsivity. In sum, there is anatomical and functional heterogeneity of human SN, which underpins value versus salience coding, and impulsive choice versus impulsive action.https://elifesciences.org/articles/26653dopaminereward prediction errorvaluesalienceimpulsivitytractography |
| spellingShingle | Yu Zhang Kevin Michel-Herve Larcher Bratislav Misic Alain Dagher Anatomical and functional organization of the human substantia nigra and its connections eLife dopamine reward prediction error value salience impulsivity tractography |
| title | Anatomical and functional organization of the human substantia nigra and its connections |
| title_full | Anatomical and functional organization of the human substantia nigra and its connections |
| title_fullStr | Anatomical and functional organization of the human substantia nigra and its connections |
| title_full_unstemmed | Anatomical and functional organization of the human substantia nigra and its connections |
| title_short | Anatomical and functional organization of the human substantia nigra and its connections |
| title_sort | anatomical and functional organization of the human substantia nigra and its connections |
| topic | dopamine reward prediction error value salience impulsivity tractography |
| url | https://elifesciences.org/articles/26653 |
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