KMT2D Deficiency Promotes Myeloid Leukemias which Is Vulnerable to Ribosome Biogenesis Inhibition

KMT2D Deficiency Promotes Myeloid Leukemias which Is Vulnerable to Ribosome Biogenesis Inhibition

Abstract KMT2C and KMT2D are the most frequently mutated epigenetic genes in human cancers. While KMT2C is identified as a tumor suppressor in acute myeloid leukemia (AML), the role of KMT2D remains unclear in this disease, though its loss promotes B cell lymphoma and various solid cancers. Here, it...

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Bibliographic Details
Main Authors: Jing Xu, Ailing Zhong, Shan Zhang, Mei Chen, Lanxin Zhang, Xiaohang Hang, Jianan Zheng, Baohong Wu, Xintong Deng, Xiangyu Pan, Zhongwang Wang, Lu Qi, Kaidou Shi, Shujun Li, Yiyun Wang, Manli Wang, Xuelan Chen, Qi Zhang, Pengpeng Liu, Robert Peter Gale, Chong Chen, Yu Liu, Ting Niu
Format: Article
Language:English
Published: Wiley 2023-07-01
Series:Advanced Science
Subjects:
acute myeloid leukemia
epigenetics
KMT2D
mTOR
ribosome biogenesis
Online Access:https://doi.org/10.1002/advs.202206098

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