The Role of the Heat Shock Protein B8 (HSPB8) in Motoneuron Diseases

The Role of the Heat Shock Protein B8 (HSPB8) in Motoneuron Diseases

Amyotrophic lateral sclerosis (ALS) and spinal and bulbar muscular atrophy (SBMA) are two motoneuron diseases (MNDs) characterized by aberrant protein behavior in affected cells. In familial ALS (fALS) and in SBMA specific gene mutations lead to the production of neurotoxic proteins or peptides pron...

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Bibliographic Details
Main Authors: Paola Rusmini, Riccardo Cristofani, Mariarita Galbiati, Maria E. Cicardi, Marco Meroni, Veronica Ferrari, Giulia Vezzoli, Barbara Tedesco, Elio Messi, Margherita Piccolella, Serena Carra, Valeria Crippa, Angelo Poletti
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Molecular Neuroscience
Subjects:
motoneuron diseases
amyotrophic lateral sclerosis
spinal and bulbar muscular atrophy
proteasome
autophagy
chaperones
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2017.00176/full

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