Thioredoxin-1 Protects Spinal Cord from Demyelination Induced by Methamphetamine through Suppressing Endoplasmic Reticulum Stress and Inflammation

Thioredoxin-1 Protects Spinal Cord from Demyelination Induced by Methamphetamine through Suppressing Endoplasmic Reticulum Stress and Inflammation

Methamphetamine (METH) is a psychostimulant abused around the world. Emerging evidence indicates that METH causes brain damage. However, there are very few reports on METH-induced demyelination. Thioredoxin-1 (Trx-1) is a redox regulating protein and plays the roles in protecting neurons from variou...

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Bibliographic Details
Main Authors: Lihua Yang, Yinli Guo, Mengbin Huang, Xiaoli Wu, Xiang Li, Guobing Chen, Ye Li, Jie Bai
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Neurology
Subjects:
methamphetamine
demyelination
thioredoxin-1
endoplasmic reticulum stress
inflammation
spinal cord
Online Access:http://journal.frontiersin.org/article/10.3389/fneur.2018.00049/full

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