Suicide Reduction in Schizophrenia via Exercise (SUnRISE): study protocol for a multi-site, single-blind, randomized clinical trial of aerobic exercise for suicide risk reduction in individuals with schizophrenia
Abstract Background Suicide risk among individuals with schizophrenia (SZ) is intractably high, with over 40% of individuals attempting to take their own lives during their lifetime and an estimated 5–10% completing suicide. At present, available pharmacological and psychotherapeutic treatments offe...
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| Format: | Article |
| Language: | English |
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BMC
2020-10-01
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| Series: | Trials |
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| Online Access: | http://link.springer.com/article/10.1186/s13063-020-04788-z |
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| author | Katie Beck-Felts Marianne Goodman Luz H. Ospina Melanie Wall Joseph McEvoy Lars F. Jarskog Jacob S. Ballon Matthew N. Bartels Richard Buchsbaum Richard P. Sloan T. Scott Stroup David Kimhy |
| author_facet | Katie Beck-Felts Marianne Goodman Luz H. Ospina Melanie Wall Joseph McEvoy Lars F. Jarskog Jacob S. Ballon Matthew N. Bartels Richard Buchsbaum Richard P. Sloan T. Scott Stroup David Kimhy |
| author_sort | Katie Beck-Felts |
| collection | DOAJ |
| description | Abstract Background Suicide risk among individuals with schizophrenia (SZ) is intractably high, with over 40% of individuals attempting to take their own lives during their lifetime and an estimated 5–10% completing suicide. At present, available pharmacological and psychotherapeutic treatments offer limited risk reduction benefits, and thus, there remains an urgent need to explore novel interventions that will ameliorate this risk. Aerobic exercise (AE) has been shown to improve a number of predictors of suicide risk (e.g., depressed mood, sleeping difficulties). As individuals with SZ display a highly sedentary lifestyle, AE may reduce suicide risk. Methods Employing a multi-site, single-blind, randomized clinical trial design, we will examine the impact of AE on risk for suicide and related variables in individuals with SZ. Participants will be randomized to one of two 12-week exercise interventions: AE or a stretching and toning (ST) control intervention. Primary outcome measures will include suicide risk (Columbia Suicide Severity Rating Scale, C-SSRS) and aerobic fitness (VO2max), along with additional measures of suicide risk, mood, emotion regulation, sleep, cognition, and physical activity, with assessments completed at baseline and after 6 and 12 weeks of interventions. Discussion It is hypothesized that AE will reduce suicide risk among individuals with SZ. This study may offer support for a more efficacious treatment method for this population in addition to the pre-existing pharmacological and psychotherapeutic treatment regimens. Trial registration Clinicaltrials.gov, NCT03270098 . Registered on September 1, 2017. |
| first_indexed | 2024-12-22T04:59:15Z |
| format | Article |
| id | doaj.art-ddf2072d6c774238853c46af9624cf2f |
| institution | Directory Open Access Journal |
| issn | 1745-6215 |
| language | English |
| last_indexed | 2024-12-22T04:59:15Z |
| publishDate | 2020-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Trials |
| spelling | doaj.art-ddf2072d6c774238853c46af9624cf2f2022-12-21T18:38:19ZengBMCTrials1745-62152020-10-0121111310.1186/s13063-020-04788-zSuicide Reduction in Schizophrenia via Exercise (SUnRISE): study protocol for a multi-site, single-blind, randomized clinical trial of aerobic exercise for suicide risk reduction in individuals with schizophreniaKatie Beck-Felts0Marianne Goodman1Luz H. Ospina2Melanie Wall3Joseph McEvoy4Lars F. Jarskog5Jacob S. Ballon6Matthew N. Bartels7Richard Buchsbaum8Richard P. Sloan9T. Scott Stroup10David Kimhy11Department of Psychiatry, Icahn School of Medicine at Mount SinaiMIRECC, James J. Peters VA Medical CenterDepartment of Psychiatry, Icahn School of Medicine at Mount SinaiDepartment of Psychiatry, Columbia UniversityDepartment of Psychiatry and Health Behavior, Georgia Regents UniversityDepartment of Psychiatry, University of North CarolinaDepartment of Psychiatry and Behavioral Sciences, Stanford UniversityDepartment of Rehabilitation Medicine, Albert Einstein College of Medicine/Montefiore Medical CenterDepartment of Psychiatry, Columbia UniversityDepartment of Psychiatry, Columbia UniversityDepartment of Psychiatry, Columbia UniversityDepartment of Psychiatry, Icahn School of Medicine at Mount SinaiAbstract Background Suicide risk among individuals with schizophrenia (SZ) is intractably high, with over 40% of individuals attempting to take their own lives during their lifetime and an estimated 5–10% completing suicide. At present, available pharmacological and psychotherapeutic treatments offer limited risk reduction benefits, and thus, there remains an urgent need to explore novel interventions that will ameliorate this risk. Aerobic exercise (AE) has been shown to improve a number of predictors of suicide risk (e.g., depressed mood, sleeping difficulties). As individuals with SZ display a highly sedentary lifestyle, AE may reduce suicide risk. Methods Employing a multi-site, single-blind, randomized clinical trial design, we will examine the impact of AE on risk for suicide and related variables in individuals with SZ. Participants will be randomized to one of two 12-week exercise interventions: AE or a stretching and toning (ST) control intervention. Primary outcome measures will include suicide risk (Columbia Suicide Severity Rating Scale, C-SSRS) and aerobic fitness (VO2max), along with additional measures of suicide risk, mood, emotion regulation, sleep, cognition, and physical activity, with assessments completed at baseline and after 6 and 12 weeks of interventions. Discussion It is hypothesized that AE will reduce suicide risk among individuals with SZ. This study may offer support for a more efficacious treatment method for this population in addition to the pre-existing pharmacological and psychotherapeutic treatment regimens. Trial registration Clinicaltrials.gov, NCT03270098 . Registered on September 1, 2017.http://link.springer.com/article/10.1186/s13063-020-04788-zSchizophreniaSuicideExerciseAerobic fitnessVO2max |
| spellingShingle | Katie Beck-Felts Marianne Goodman Luz H. Ospina Melanie Wall Joseph McEvoy Lars F. Jarskog Jacob S. Ballon Matthew N. Bartels Richard Buchsbaum Richard P. Sloan T. Scott Stroup David Kimhy Suicide Reduction in Schizophrenia via Exercise (SUnRISE): study protocol for a multi-site, single-blind, randomized clinical trial of aerobic exercise for suicide risk reduction in individuals with schizophrenia Trials Schizophrenia Suicide Exercise Aerobic fitness VO2max |
| title | Suicide Reduction in Schizophrenia via Exercise (SUnRISE): study protocol for a multi-site, single-blind, randomized clinical trial of aerobic exercise for suicide risk reduction in individuals with schizophrenia |
| title_full | Suicide Reduction in Schizophrenia via Exercise (SUnRISE): study protocol for a multi-site, single-blind, randomized clinical trial of aerobic exercise for suicide risk reduction in individuals with schizophrenia |
| title_fullStr | Suicide Reduction in Schizophrenia via Exercise (SUnRISE): study protocol for a multi-site, single-blind, randomized clinical trial of aerobic exercise for suicide risk reduction in individuals with schizophrenia |
| title_full_unstemmed | Suicide Reduction in Schizophrenia via Exercise (SUnRISE): study protocol for a multi-site, single-blind, randomized clinical trial of aerobic exercise for suicide risk reduction in individuals with schizophrenia |
| title_short | Suicide Reduction in Schizophrenia via Exercise (SUnRISE): study protocol for a multi-site, single-blind, randomized clinical trial of aerobic exercise for suicide risk reduction in individuals with schizophrenia |
| title_sort | suicide reduction in schizophrenia via exercise sunrise study protocol for a multi site single blind randomized clinical trial of aerobic exercise for suicide risk reduction in individuals with schizophrenia |
| topic | Schizophrenia Suicide Exercise Aerobic fitness VO2max |
| url | http://link.springer.com/article/10.1186/s13063-020-04788-z |
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