Genome-wide association studies and fine-mapping identify genomic loci for n-3 and n-6 polyunsaturated fatty acids in Hispanic American and African American cohorts

Genome-wide association studies and fine-mapping identify genomic loci for n-3 and n-6 polyunsaturated fatty acids in Hispanic American and African American cohorts

Abstract Omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acids (PUFAs) play critical roles in human health. Prior genome-wide association studies (GWAS) of n-3 and n-6 PUFAs in European Americans from the CHARGE Consortium have documented strong genetic signals in/near the FADS locus on chromo...

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Bibliographic Details
Main Authors: Chaojie Yang, Jenna Veenstra, Traci M. Bartz, Matthew C. Pahl, Brian Hallmark, Yii-Der Ida Chen, Jason Westra, Lyn M. Steffen, Christopher D. Brown, David Siscovick, Michael Y. Tsai, Alexis C. Wood, Stephen S. Rich, Caren E. Smith, Timothy D. O’Connor, Dariush Mozaffarian, Struan F. A. Grant, Floyd H. Chilton, Nathan L. Tintle, Rozenn N. Lemaitre, Ani Manichaikul
Format: Article
Language:English
Published: Nature Portfolio 2023-08-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-023-05219-w

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