Role of Radiotherapy in Locally Advanced, Fungating, and Inoperable Breast Cancer
Introduction In India, majority of patients are diagnosed with breast cancer in locally advanced stage. Surgery, chemotherapy, and radiotherapy (RT) are the mainstay of treatment for many patients who are not fit for surgery and need local RT. Materials and Methods This was a single-center, nonstra...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Thieme Medical Publishers, Inc.
2020-01-01
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| Series: | Asian Journal of Oncology |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0040-1702907 |
| Summary: | Introduction In India, majority of patients are diagnosed with breast cancer in locally advanced stage. Surgery, chemotherapy, and radiotherapy (RT) are the mainstay of treatment for many patients who are not fit for surgery and need local RT.
Materials and Methods This was a single-center, nonstratified, single-blind, nonplacebo-controlled parallel group intervention study with imbalanced randomization done at our institute. Adult patients of 30 to 65 years of age with histologically proven carcinoma of breast with biopsy were registered and assessed.
Results In total, 30 patients were included in the study and the mean age was 50 years. All the patients received 30 Gy/10 fractions in 2 weeks and the response was assessed after 4 weeks of completion of RT. Twelve patients observed more than 70% reduction in tumor size and good subjective relief, nine patients observed 40% reduction in tumor size, and six patients observed 30% reduction in tumor size. Two patients did not show any response to RT, while one patient did show progress. All patients received chemotherapy before RT and 28 patients received chemotherapy after RT.
Conclusion Thus, whether it is 20 Gy in 5 fractions or 30 Gy in 10 fractions is debatable and needs further study of larger group to establish their benefit on each other. However, 30 Gy in 10 fractions gives good subjective response to patients and improves the quality of life. |
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| ISSN: | 2454-6798 2455-4618 |