Immune responses to gp82 provide protection against mucosal Trypanosoma cruzi infection

Immune responses to gp82 provide protection against mucosal Trypanosoma cruzi infection

The potential use of the Trypanosoma cruzi metacyclic trypomastigote (MT) stage-specific molecule glycoprotein-82 (gp82) as a vaccine target has not been fully explored. We show that the opsonization of T. cruzi MT with gp82-specific antibody prior to mucosal challenge significantly reduces parasite...

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Bibliographic Details
Main Authors: Christopher S Eickhoff, Olivia K Giddings, Nobuko Yoshida, Daniel F Hoft
Format: Article
Language:English
Published: Fundação Oswaldo Cruz (FIOCRUZ) 2010-08-01
Series:Memorias do Instituto Oswaldo Cruz
Subjects:
Trypanosoma cruzi
mucosal immunity
vaccines
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762010000500015

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