Dual antidiabetic and antihypertensive activity of fucoxanthin isolated from Sargassum wightii Greville in in vivo rat model
In a previous study from our laboratory, fucoxanthin purified from brown algae, Sargassum wightii Greville has found to exhibit antioxidant activity and inhibition of angiotensin-I-converting enzyme (ACE) in vitro. The present study aims in understanding the protective effect of fucoxanthin purified...
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Tsinghua University Press
2023-09-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S221345302300037X |
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| author | Vijayan Raji Chitra Loganathan Thiyagarajan Ramesh Palvannan Thayumanavan |
| author_facet | Vijayan Raji Chitra Loganathan Thiyagarajan Ramesh Palvannan Thayumanavan |
| author_sort | Vijayan Raji |
| collection | DOAJ |
| description | In a previous study from our laboratory, fucoxanthin purified from brown algae, Sargassum wightii Greville has found to exhibit antioxidant activity and inhibition of angiotensin-I-converting enzyme (ACE) in vitro. The present study aims in understanding the protective effect of fucoxanthin purified from S. wightii against diabetes with hypertension in in vivo. Diabetes and hypertension were induced in rat by streptozotocin and sodium chloride treatment, respectively. In diabetes with hypertension rat, the blood pressure was increased along with hyperglycemia. Administration of fucoxanthin significantly reduced the blood pressure and ACE activity in diabetes with hypertension rat. Furthermore, administration of fucoxanthin significantly reduced the hyperglycemic state. The activity of various enzymes in the liver (hexokinase, glucose-6-phosphate dehydrogenase, glucose-6-phosphatase and fructose-1,6-phosphatase) and serum (creatine kinase) were normalized to that of control level. The level of glycogen, glycoprotein component and lipid profile were equivalent to control level by fucoxanthin administration in diabetes with hypertension rats. Fucoxanthin ameliorated the oxidative stress by preserving the endogenous antioxidant levels in diabetes with hypertension rats. Also, the pancreatic histological integrity was similar to that of control level in diabetes with hypertension rats by fucoxanthin treatment. Altogether, fucoxanthin showed dual antidiabetic and antihypertensive activity in vivo. |
| first_indexed | 2024-03-12T04:39:29Z |
| format | Article |
| id | doaj.art-ddfbef4d27044c99bd28ac795e5e6a74 |
| institution | Directory Open Access Journal |
| issn | 2213-4530 |
| language | English |
| last_indexed | 2024-03-12T04:39:29Z |
| publishDate | 2023-09-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj.art-ddfbef4d27044c99bd28ac795e5e6a742023-09-03T09:48:13ZengTsinghua University PressFood Science and Human Wellness2213-45302023-09-0112516931700Dual antidiabetic and antihypertensive activity of fucoxanthin isolated from Sargassum wightii Greville in in vivo rat modelVijayan Raji0Chitra Loganathan1Thiyagarajan Ramesh2Palvannan Thayumanavan3Department of Biochemistry, Periyar University, Salem, Tamil Nadu 636011, IndiaDepartment of Biochemistry, Periyar University, Salem, Tamil Nadu 636011, IndiaDepartment of Basic Medical Sciences, College of Medicine, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Kingdom of Saudi ArabiaDepartment of Biochemistry, Periyar University, Salem, Tamil Nadu 636011, India; Corresponding author at: Department of Biochemistry, Periyar University, Salem, Tamil Nadu 636011, India.In a previous study from our laboratory, fucoxanthin purified from brown algae, Sargassum wightii Greville has found to exhibit antioxidant activity and inhibition of angiotensin-I-converting enzyme (ACE) in vitro. The present study aims in understanding the protective effect of fucoxanthin purified from S. wightii against diabetes with hypertension in in vivo. Diabetes and hypertension were induced in rat by streptozotocin and sodium chloride treatment, respectively. In diabetes with hypertension rat, the blood pressure was increased along with hyperglycemia. Administration of fucoxanthin significantly reduced the blood pressure and ACE activity in diabetes with hypertension rat. Furthermore, administration of fucoxanthin significantly reduced the hyperglycemic state. The activity of various enzymes in the liver (hexokinase, glucose-6-phosphate dehydrogenase, glucose-6-phosphatase and fructose-1,6-phosphatase) and serum (creatine kinase) were normalized to that of control level. The level of glycogen, glycoprotein component and lipid profile were equivalent to control level by fucoxanthin administration in diabetes with hypertension rats. Fucoxanthin ameliorated the oxidative stress by preserving the endogenous antioxidant levels in diabetes with hypertension rats. Also, the pancreatic histological integrity was similar to that of control level in diabetes with hypertension rats by fucoxanthin treatment. Altogether, fucoxanthin showed dual antidiabetic and antihypertensive activity in vivo.http://www.sciencedirect.com/science/article/pii/S221345302300037XFucoxanthinDiabetesHypertensionOxidative stressAngiotensin-I-converting enzyme |
| spellingShingle | Vijayan Raji Chitra Loganathan Thiyagarajan Ramesh Palvannan Thayumanavan Dual antidiabetic and antihypertensive activity of fucoxanthin isolated from Sargassum wightii Greville in in vivo rat model Food Science and Human Wellness Fucoxanthin Diabetes Hypertension Oxidative stress Angiotensin-I-converting enzyme |
| title | Dual antidiabetic and antihypertensive activity of fucoxanthin isolated from Sargassum wightii Greville in in vivo rat model |
| title_full | Dual antidiabetic and antihypertensive activity of fucoxanthin isolated from Sargassum wightii Greville in in vivo rat model |
| title_fullStr | Dual antidiabetic and antihypertensive activity of fucoxanthin isolated from Sargassum wightii Greville in in vivo rat model |
| title_full_unstemmed | Dual antidiabetic and antihypertensive activity of fucoxanthin isolated from Sargassum wightii Greville in in vivo rat model |
| title_short | Dual antidiabetic and antihypertensive activity of fucoxanthin isolated from Sargassum wightii Greville in in vivo rat model |
| title_sort | dual antidiabetic and antihypertensive activity of fucoxanthin isolated from sargassum wightii greville in in vivo rat model |
| topic | Fucoxanthin Diabetes Hypertension Oxidative stress Angiotensin-I-converting enzyme |
| url | http://www.sciencedirect.com/science/article/pii/S221345302300037X |
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