Severity of Idiopathic Scoliosis Is Associated with Differential Methylation: An Epigenome-Wide Association Study of Monozygotic Twins with Idiopathic Scoliosis

Severity of Idiopathic Scoliosis Is Associated with Differential Methylation: An Epigenome-Wide Association Study of Monozygotic Twins with Idiopathic Scoliosis

Epigenetic mechanisms may contribute to idiopathic scoliosis (IS). We identified 8 monozygotic twin pairs with IS, 6 discordant (Cobb angle difference > 10°) and 2 concordant (Cobb angle difference ≤ 2°). Genome-wide methylation in blood was measured with the Infinium HumanMethylation EPIC Beadch...

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Bibliographic Details
Main Authors: Patrick M. Carry, Elizabeth A. Terhune, George D. Trahan, Lauren A. Vanderlinden, Cambria I. Wethey, Parvaneh Ebrahimi, Fiona McGuigan, Kristina Åkesson, Nancy Hadley-Miller
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Genes
Subjects:
idiopathic scoliosis
monozygotic twin
epigenome-wide association study
DNA methylation
bone
discordant
Online Access:https://www.mdpi.com/2073-4425/12/8/1191

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