Lactobacillus casei T1 from kurut against Helicobacter pylori-induced inflammation and the gut microbial disorder
Probiotics have the functions of inhibiting pathogen infection and maintaining gastrointestinal homeostasis. The aim of this study was to investigate the preventive effect of Lactobacillus casei T1 (L. casei T1) isolated from kurut against the gastric inflammation and gut microbiota alteration induc...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2021-10-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464621002607 |
| _version_ | 1818693528091361280 |
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| author | Daoyan Wu Mei Cao Jie Zhou Shiying Yan Jingshan Peng Zhihao Yu Andong Zhang Jialin Wu Xin Yan Jian Zhao |
| author_facet | Daoyan Wu Mei Cao Jie Zhou Shiying Yan Jingshan Peng Zhihao Yu Andong Zhang Jialin Wu Xin Yan Jian Zhao |
| author_sort | Daoyan Wu |
| collection | DOAJ |
| description | Probiotics have the functions of inhibiting pathogen infection and maintaining gastrointestinal homeostasis. The aim of this study was to investigate the preventive effect of Lactobacillus casei T1 (L. casei T1) isolated from kurut against the gastric inflammation and gut microbiota alteration induced by Helicobacter pylori (H. pylori) infection. The results showed that L. casei T1 and its supernatant had a potent inhibitory effect on H. pylori growth in vitro. L. casei T1 adhered to GES-1 cells, down-regulated the expression of MUC5AC, IL-6, IL-8 and TNF-α in GES-1 cells induced by H. pylori. This followed by in vivo studies demonstrated that L. casei T1 pretreatment alleviated gastric inflammation and prevent gut microbiota alteration caused by H. pylori infection. These results demonstrated that L. casei T1 have a preventive effect against H. pylori infection and it can be served as a further development and utilization of probiotic. |
| first_indexed | 2024-12-17T13:15:07Z |
| format | Article |
| id | doaj.art-ddfe69c47eff4594baea217ef35b3d2c |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-17T13:15:07Z |
| publishDate | 2021-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-ddfe69c47eff4594baea217ef35b3d2c2022-12-21T21:47:01ZengElsevierJournal of Functional Foods1756-46462021-10-0185104611Lactobacillus casei T1 from kurut against Helicobacter pylori-induced inflammation and the gut microbial disorderDaoyan Wu0Mei Cao1Jie Zhou2Shiying Yan3Jingshan Peng4Zhihao Yu5Andong Zhang6Jialin Wu7Xin Yan8Jian Zhao9Key Laboratory of Biological Resource and Ecological Environment of Chinese Education Ministry, College of Life Sciences, Sichuan University, Chengdu 610064, PR China; Department of Microbiology, School of Basic Medical Sciences, Guizhou Medical University, Guiyang 550025, PR ChinaCore Laboratory, School of Medicine, Sichuan Provincial People’s Hospital Affiliated to University of Electronic Science and Technology of China, Chengdu 610072, PR ChinaKey Laboratory of Biological Resource and Ecological Environment of Chinese Education Ministry, College of Life Sciences, Sichuan University, Chengdu 610064, PR ChinaKey Laboratory of Biological Resource and Ecological Environment of Chinese Education Ministry, College of Life Sciences, Sichuan University, Chengdu 610064, PR ChinaKey Laboratory of Biological Resource and Ecological Environment of Chinese Education Ministry, College of Life Sciences, Sichuan University, Chengdu 610064, PR ChinaKey Laboratory of Biological Resource and Ecological Environment of Chinese Education Ministry, College of Life Sciences, Sichuan University, Chengdu 610064, PR ChinaKey Laboratory of Biological Resource and Ecological Environment of Chinese Education Ministry, College of Life Sciences, Sichuan University, Chengdu 610064, PR ChinaKey Laboratory of Biological Resource and Ecological Environment of Chinese Education Ministry, College of Life Sciences, Sichuan University, Chengdu 610064, PR ChinaKey Laboratory of Biological Resource and Ecological Environment of Chinese Education Ministry, College of Life Sciences, Sichuan University, Chengdu 610064, PR ChinaKey Laboratory of Biological Resource and Ecological Environment of Chinese Education Ministry, College of Life Sciences, Sichuan University, Chengdu 610064, PR China; Corresponding author.Probiotics have the functions of inhibiting pathogen infection and maintaining gastrointestinal homeostasis. The aim of this study was to investigate the preventive effect of Lactobacillus casei T1 (L. casei T1) isolated from kurut against the gastric inflammation and gut microbiota alteration induced by Helicobacter pylori (H. pylori) infection. The results showed that L. casei T1 and its supernatant had a potent inhibitory effect on H. pylori growth in vitro. L. casei T1 adhered to GES-1 cells, down-regulated the expression of MUC5AC, IL-6, IL-8 and TNF-α in GES-1 cells induced by H. pylori. This followed by in vivo studies demonstrated that L. casei T1 pretreatment alleviated gastric inflammation and prevent gut microbiota alteration caused by H. pylori infection. These results demonstrated that L. casei T1 have a preventive effect against H. pylori infection and it can be served as a further development and utilization of probiotic.http://www.sciencedirect.com/science/article/pii/S1756464621002607Helicobacter pyloriLactobacillus casei T1ProbioticInflammationGut microbiota |
| spellingShingle | Daoyan Wu Mei Cao Jie Zhou Shiying Yan Jingshan Peng Zhihao Yu Andong Zhang Jialin Wu Xin Yan Jian Zhao Lactobacillus casei T1 from kurut against Helicobacter pylori-induced inflammation and the gut microbial disorder Journal of Functional Foods Helicobacter pylori Lactobacillus casei T1 Probiotic Inflammation Gut microbiota |
| title | Lactobacillus casei T1 from kurut against Helicobacter pylori-induced inflammation and the gut microbial disorder |
| title_full | Lactobacillus casei T1 from kurut against Helicobacter pylori-induced inflammation and the gut microbial disorder |
| title_fullStr | Lactobacillus casei T1 from kurut against Helicobacter pylori-induced inflammation and the gut microbial disorder |
| title_full_unstemmed | Lactobacillus casei T1 from kurut against Helicobacter pylori-induced inflammation and the gut microbial disorder |
| title_short | Lactobacillus casei T1 from kurut against Helicobacter pylori-induced inflammation and the gut microbial disorder |
| title_sort | lactobacillus casei t1 from kurut against helicobacter pylori induced inflammation and the gut microbial disorder |
| topic | Helicobacter pylori Lactobacillus casei T1 Probiotic Inflammation Gut microbiota |
| url | http://www.sciencedirect.com/science/article/pii/S1756464621002607 |
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