Transcriptional reprogramming from innate immune functions to a pro-thrombotic signature by monocytes in COVID-19
Although myeloid cell dysfunction has been observed in COVID-19, the underlying mechanisms remain incompletely understood. Here, the authors demonstrate that monocytes from patients with mild to moderate COVID-19 show a blunted innate immune response and a pro-thrombotic signature following secondar...
Full description
Bibliographic Details
| Main Authors: |
Allison K. Maher,
Katie L. Burnham,
Emma M. Jones,
Michelle M. H. Tan,
Rocel C. Saputil,
Laury Baillon,
Claudia Selck,
Nicolas Giang,
Rafael Argüello,
Clio Pillay,
Emma Thorley,
Charlotte-Eve Short,
Rachael Quinlan,
Wendy S. Barclay,
Nichola Cooper,
Graham P. Taylor,
Emma E. Davenport,
Margarita Dominguez-Villar |
|---|
| Format: | Article
|
|---|
| Language: | English |
|---|
| Published: |
Nature Portfolio
2022-12-01
|
|---|
| Series: | Nature Communications
|
|---|
| Online Access: | https://doi.org/10.1038/s41467-022-35638-y
|
|---|