Ebola virus (<i>Filoviridae: Ebolavirus: Zaire ebolavirus</i>): fatal adaptation mutations
Ebola virus disease (EVD) (former Ebola hemorrhagic fever) is one of the most dangerous infectious diseases affecting humans and primates. Since the identification of the first outbreak in 1976, there have been more than 25 outbreaks worldwide, the largest of which escalated into an epidemic in 2014...
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Central Research Institute for Epidemiology
2021-03-01
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| Series: | Вопросы вирусологии |
| Subjects: | |
| Online Access: | https://virusjour.crie.ru/jour/article/viewFile/472/295 |
| _version_ | 1797782309866307584 |
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| author | I. V. Dolzhikova D. N. Shcherbinin D. Yu. Logunov A. L. Gintsburg |
| author_facet | I. V. Dolzhikova D. N. Shcherbinin D. Yu. Logunov A. L. Gintsburg |
| author_sort | I. V. Dolzhikova |
| collection | DOAJ |
| description | Ebola virus disease (EVD) (former Ebola hemorrhagic fever) is one of the most dangerous infectious diseases affecting humans and primates. Since the identification of the first outbreak in 1976, there have been more than 25 outbreaks worldwide, the largest of which escalated into an epidemic in 2014-2016 and caused the death of more than 11,000 people. There are currently 2 independent outbreaks of this disease in the eastern and western parts of the Democratic Republic of the Congo (DRC) at the same time. Bats (Microchiroptera) are supposed to be the natural reservoir of EVD, but the infectious agent has not yet been isolated from them. Most animal viruses are unable to replicate in humans. They have to develop adaptive mutations (AM) to become infectious for humans. In this review based on the results of a number of studies, we hypothesize that the formation of AM occurs directly in the human and primate population and subsequently leads to the development of EVD outbreaks. |
| first_indexed | 2024-03-13T00:09:09Z |
| format | Article |
| id | doaj.art-de0310bfeca04f14b8df241a738a63a9 |
| institution | Directory Open Access Journal |
| issn | 0507-4088 2411-2097 |
| language | English |
| last_indexed | 2024-03-13T00:09:09Z |
| publishDate | 2021-03-01 |
| publisher | Central Research Institute for Epidemiology |
| record_format | Article |
| series | Вопросы вирусологии |
| spelling | doaj.art-de0310bfeca04f14b8df241a738a63a92023-07-12T19:56:57ZengCentral Research Institute for EpidemiologyВопросы вирусологии0507-40882411-20972021-03-0166171610.36233/0507-4088-23366Ebola virus (<i>Filoviridae: Ebolavirus: Zaire ebolavirus</i>): fatal adaptation mutationsI. V. Dolzhikova0https://orcid.org/0000-0003-2548-6142D. N. Shcherbinin1https://orcid.org/0000-0002-8518-1669D. Yu. Logunov2https://orcid.org/0000-0003-4035-6581A. L. Gintsburg3https://orcid.org/0000-0003-1769-5059FSBI National Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya of the Ministry of Health of RussiaFSBI National Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya of the Ministry of Health of RussiaFSBI National Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya of the Ministry of Health of RussiaFSBI National Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya of the Ministry of Health of RussiaEbola virus disease (EVD) (former Ebola hemorrhagic fever) is one of the most dangerous infectious diseases affecting humans and primates. Since the identification of the first outbreak in 1976, there have been more than 25 outbreaks worldwide, the largest of which escalated into an epidemic in 2014-2016 and caused the death of more than 11,000 people. There are currently 2 independent outbreaks of this disease in the eastern and western parts of the Democratic Republic of the Congo (DRC) at the same time. Bats (Microchiroptera) are supposed to be the natural reservoir of EVD, but the infectious agent has not yet been isolated from them. Most animal viruses are unable to replicate in humans. They have to develop adaptive mutations (AM) to become infectious for humans. In this review based on the results of a number of studies, we hypothesize that the formation of AM occurs directly in the human and primate population and subsequently leads to the development of EVD outbreaks.https://virusjour.crie.ru/jour/article/viewFile/472/295ebola virusadaptation mutations |
| spellingShingle | I. V. Dolzhikova D. N. Shcherbinin D. Yu. Logunov A. L. Gintsburg Ebola virus (<i>Filoviridae: Ebolavirus: Zaire ebolavirus</i>): fatal adaptation mutations Вопросы вирусологии ebola virus adaptation mutations |
| title | Ebola virus (<i>Filoviridae: Ebolavirus: Zaire ebolavirus</i>): fatal adaptation mutations |
| title_full | Ebola virus (<i>Filoviridae: Ebolavirus: Zaire ebolavirus</i>): fatal adaptation mutations |
| title_fullStr | Ebola virus (<i>Filoviridae: Ebolavirus: Zaire ebolavirus</i>): fatal adaptation mutations |
| title_full_unstemmed | Ebola virus (<i>Filoviridae: Ebolavirus: Zaire ebolavirus</i>): fatal adaptation mutations |
| title_short | Ebola virus (<i>Filoviridae: Ebolavirus: Zaire ebolavirus</i>): fatal adaptation mutations |
| title_sort | ebola virus i filoviridae ebolavirus zaire ebolavirus i fatal adaptation mutations |
| topic | ebola virus adaptation mutations |
| url | https://virusjour.crie.ru/jour/article/viewFile/472/295 |
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