Fecal transplantation: passing fashion or here to stay?
Several trillions of bacteria, distributed among more than 1,000 species, are natural inhabitants of the human intestinal tract and constitute what is now known as the gut microbiota. Although its composition varies within and between individuals with age, diet, and health status, it is becoming inc...
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| Format: | Article |
| Language: | English |
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Hospital de Clinicas de Porto Alegre ; Universidade Federal do Rio Grande do Sul (UFRGS)
2014-10-01
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| Series: | Clinical and Biomedical Research |
| Subjects: | |
| Online Access: | http://seer.ufrgs.br/hcpa/article/view/49219 |
| _version_ | 1818494204081340416 |
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| author | Tyrone L. Pitt |
| author_facet | Tyrone L. Pitt |
| author_sort | Tyrone L. Pitt |
| collection | DOAJ |
| description | Several trillions of bacteria, distributed among more than 1,000 species, are natural inhabitants of the human intestinal tract and constitute what is now known as the gut microbiota. Although its composition varies within and between individuals with age, diet, and health status, it is becoming increasingly recognized that imbalances in the bacterial microbiota (dysbiosis) are linked to a number of conditions such as antibiotic-associated diarrhea, inflammatory bowel disease, and obesity, among others. Fecal transplantation where a preparation of stool from a microbiologically screened- donor is administered into the colon of an affected recipient has been shown to be highly effective for the treatment of recurrent Clostridium difficile infection. Several trials of this therapy are now underway for gut dysbiosis in a number of patient disease groups raising concerns on the risk of transmission of infectious agents from donor to recipient, possible long-term adverse consequences of treatment, and effective regulation of the stool material used for the procedure. A worrying aspect is the emergence of private stool banks providing samples to the general public for self-administration. |
| first_indexed | 2024-12-10T18:03:29Z |
| format | Article |
| id | doaj.art-de03399736ea48adb604f0f9090b788b |
| institution | Directory Open Access Journal |
| issn | 0101-5575 2357-9730 |
| language | English |
| last_indexed | 2024-12-10T18:03:29Z |
| publishDate | 2014-10-01 |
| publisher | Hospital de Clinicas de Porto Alegre ; Universidade Federal do Rio Grande do Sul (UFRGS) |
| record_format | Article |
| series | Clinical and Biomedical Research |
| spelling | doaj.art-de03399736ea48adb604f0f9090b788b2022-12-22T01:38:41ZengHospital de Clinicas de Porto Alegre ; Universidade Federal do Rio Grande do Sul (UFRGS)Clinical and Biomedical Research0101-55752357-97302014-10-0134325889Fecal transplantation: passing fashion or here to stay?Tyrone L. PittSeveral trillions of bacteria, distributed among more than 1,000 species, are natural inhabitants of the human intestinal tract and constitute what is now known as the gut microbiota. Although its composition varies within and between individuals with age, diet, and health status, it is becoming increasingly recognized that imbalances in the bacterial microbiota (dysbiosis) are linked to a number of conditions such as antibiotic-associated diarrhea, inflammatory bowel disease, and obesity, among others. Fecal transplantation where a preparation of stool from a microbiologically screened- donor is administered into the colon of an affected recipient has been shown to be highly effective for the treatment of recurrent Clostridium difficile infection. Several trials of this therapy are now underway for gut dysbiosis in a number of patient disease groups raising concerns on the risk of transmission of infectious agents from donor to recipient, possible long-term adverse consequences of treatment, and effective regulation of the stool material used for the procedure. A worrying aspect is the emergence of private stool banks providing samples to the general public for self-administration.http://seer.ufrgs.br/hcpa/article/view/49219Transplantation |
| spellingShingle | Tyrone L. Pitt Fecal transplantation: passing fashion or here to stay? Clinical and Biomedical Research Transplantation |
| title | Fecal transplantation: passing fashion or here to stay? |
| title_full | Fecal transplantation: passing fashion or here to stay? |
| title_fullStr | Fecal transplantation: passing fashion or here to stay? |
| title_full_unstemmed | Fecal transplantation: passing fashion or here to stay? |
| title_short | Fecal transplantation: passing fashion or here to stay? |
| title_sort | fecal transplantation passing fashion or here to stay |
| topic | Transplantation |
| url | http://seer.ufrgs.br/hcpa/article/view/49219 |
| work_keys_str_mv | AT tyronelpitt fecaltransplantationpassingfashionorheretostay |