Relevance of Fluorinated Ligands to the Design of Metallodrugs for Their Potential Use in Cancer Treatment
Fluorination of pharmaceutical agents has afforded crucial modifications to their pharmacological profiles, leading to important advances in medicinal chemistry. On the other hand, metallodrugs are considered to be valuable candidates in the treatment of several diseases, albeit with the caveat that...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/14/2/402 |
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| author | José C. Páez-Franco Miriam R. Zermeño-Ortega Carmen Myriam de la O-Contreras Daniel Canseco-González Jesus R. Parra-Unda Alcives Avila-Sorrosa Raúl G. Enríquez Juan M. Germán-Acacio David Morales-Morales |
| author_facet | José C. Páez-Franco Miriam R. Zermeño-Ortega Carmen Myriam de la O-Contreras Daniel Canseco-González Jesus R. Parra-Unda Alcives Avila-Sorrosa Raúl G. Enríquez Juan M. Germán-Acacio David Morales-Morales |
| author_sort | José C. Páez-Franco |
| collection | DOAJ |
| description | Fluorination of pharmaceutical agents has afforded crucial modifications to their pharmacological profiles, leading to important advances in medicinal chemistry. On the other hand, metallodrugs are considered to be valuable candidates in the treatment of several diseases, albeit with the caveat that they may exhibit pharmacological disadvantages, such as poor water solubility, low bioavailability and short circulating time. To surmount these limitations, two approaches have been developed: one based on the design of novel metallodrug-delivering carriers and the other based on optimizing the structure of the ligands bound to the metal center. In this context, fluorination of the ligands may bring beneficial changes (physicochemical and biological) that can help to elude the aforementioned drawbacks. Thus, in this review, we discuss the use of fluorinated ligands in the design of metallodrugs that may exhibit potential anticancer activity. |
| first_indexed | 2024-03-09T21:14:26Z |
| format | Article |
| id | doaj.art-de0466249f3545c4a9d8dd7e62625230 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T21:14:26Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-de0466249f3545c4a9d8dd7e626252302023-11-23T21:38:44ZengMDPI AGPharmaceutics1999-49232022-02-0114240210.3390/pharmaceutics14020402Relevance of Fluorinated Ligands to the Design of Metallodrugs for Their Potential Use in Cancer TreatmentJosé C. Páez-Franco0Miriam R. Zermeño-Ortega1Carmen Myriam de la O-Contreras2Daniel Canseco-González3Jesus R. Parra-Unda4Alcives Avila-Sorrosa5Raúl G. Enríquez6Juan M. Germán-Acacio7David Morales-Morales8Red de Apoyo a la Investigación, Coordinación de la Investigación Científica-UNAM, Instituto Nacional de Ciencias Médicas y Nutrición SZ, Ciudad de Mexico CP 14000, MexicoFacultad de Ciencias Químicas, Universidad Autónoma de Chihuahua (UACH), Circuito Universitario S/N, Chihuahua CP 31125, Chihuahua, MexicoFacultad de Ciencias Químicas, Universidad Autónoma de Chihuahua (UACH), Circuito Universitario S/N, Chihuahua CP 31125, Chihuahua, MexicoCONACYT-Laboratorio Nacional de Investigación y Servicio Agroalimentario y Forestal, Universidad Autónoma Chapingo, Texcoco de Mora CP 56230, MexicoSchool of Chemical and Biological Sciences, Autonomous University of Sinaloa (Ciudad Universitaria), Culiacan CP 80010, Sinaloa, MexicoDepartamento de Química Orgánica, Instituto Politécnico Nacional, Escuela Nacional de Ciencias Biológicas, Carpio y Plan de Ayala S/N, Colonia Santo Tomás, Ciudad de Mexico CP 11340, MexicoInstituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Ciudad de Mexico CP 04510, MexicoRed de Apoyo a la Investigación, Coordinación de la Investigación Científica-UNAM, Instituto Nacional de Ciencias Médicas y Nutrición SZ, Ciudad de Mexico CP 14000, MexicoInstituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Ciudad de Mexico CP 04510, MexicoFluorination of pharmaceutical agents has afforded crucial modifications to their pharmacological profiles, leading to important advances in medicinal chemistry. On the other hand, metallodrugs are considered to be valuable candidates in the treatment of several diseases, albeit with the caveat that they may exhibit pharmacological disadvantages, such as poor water solubility, low bioavailability and short circulating time. To surmount these limitations, two approaches have been developed: one based on the design of novel metallodrug-delivering carriers and the other based on optimizing the structure of the ligands bound to the metal center. In this context, fluorination of the ligands may bring beneficial changes (physicochemical and biological) that can help to elude the aforementioned drawbacks. Thus, in this review, we discuss the use of fluorinated ligands in the design of metallodrugs that may exhibit potential anticancer activity.https://www.mdpi.com/1999-4923/14/2/402organometallicscoordination complexesmetallodrugsfluorinated ligandsanticancer activitycancer |
| spellingShingle | José C. Páez-Franco Miriam R. Zermeño-Ortega Carmen Myriam de la O-Contreras Daniel Canseco-González Jesus R. Parra-Unda Alcives Avila-Sorrosa Raúl G. Enríquez Juan M. Germán-Acacio David Morales-Morales Relevance of Fluorinated Ligands to the Design of Metallodrugs for Their Potential Use in Cancer Treatment Pharmaceutics organometallics coordination complexes metallodrugs fluorinated ligands anticancer activity cancer |
| title | Relevance of Fluorinated Ligands to the Design of Metallodrugs for Their Potential Use in Cancer Treatment |
| title_full | Relevance of Fluorinated Ligands to the Design of Metallodrugs for Their Potential Use in Cancer Treatment |
| title_fullStr | Relevance of Fluorinated Ligands to the Design of Metallodrugs for Their Potential Use in Cancer Treatment |
| title_full_unstemmed | Relevance of Fluorinated Ligands to the Design of Metallodrugs for Their Potential Use in Cancer Treatment |
| title_short | Relevance of Fluorinated Ligands to the Design of Metallodrugs for Their Potential Use in Cancer Treatment |
| title_sort | relevance of fluorinated ligands to the design of metallodrugs for their potential use in cancer treatment |
| topic | organometallics coordination complexes metallodrugs fluorinated ligands anticancer activity cancer |
| url | https://www.mdpi.com/1999-4923/14/2/402 |
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