COMPARISON OF CLINICAL EFFICACY OF ORIGINAL BISOPROLOL AND ITS GENERIC DRUG IN PATIENTS WITH STABLE ANGINA AND CONCOMITANT CHRONIC OBSTRUCTIVE PULMONARY DISEASE
Aim. To compare clinical efficacy and effect on endothelium function of original bisoprolol and its generic in patients with stable angina and concomitant chronic obstructive pulmonary disease (COPD).Material and methods. Patients with the stable angina and COPD (n=72) were included into the study....
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Столичная издательская компания
2016-01-01
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| Series: | Рациональная фармакотерапия в кардиологии |
| Subjects: | |
| Online Access: | https://www.rpcardio.online/jour/article/view/847 |
| Summary: | Aim. To compare clinical efficacy and effect on endothelium function of original bisoprolol and its generic in patients with stable angina and concomitant chronic obstructive pulmonary disease (COPD).Material and methods. Patients with the stable angina and COPD (n=72) were included into the study. Patients were randomized for treatment with the original bisoprolol (1st group; n=36) and the generic bisoprolol (2nd group; n=36). Endothelium-dependent vasodilation test, office measurement of heart rate in 2 hours after bisoprolol taking, 24-hour electrocardiogram-monitoring, evaluation of respiratory function, level of nitrogen oxide metabolites were are performed initially and in 12 weeks.Results. Antihypertensive and antiischemic effects were observed in both groups in 12 weeks of treatment. However significant improvements of endothelial function were detected only in patients of the 1st group. Heart rate reduction from 98.6±2.5 to 58.6±3.5 bt/min (р<0.001) was found with the 24 hour electrocardiogram-monitoring after 12 weeks of therapy in the 1st group and from 96.9±4.9 to 66.3±5.6 bt/min (р<0.001) in the 2nd group. Reached heart rate level in the 1st group was less than this in the 2nd group (р<0.001). Negative changes of respiratory function were absent in the both groups in 4 weeks of treatment, however significant reduction of respiratory indices was registered in the 2nd group after 12 weeks of treatment.Conclusion. Original bisoprolol is more effective and tolerable than generic bisoprolol in patients with the stable angina and concomitant COPD. |
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| ISSN: | 1819-6446 2225-3653 |