Deferasirox – a rarer cause of Fanconi syndrome
Deferasirox is a recently approved iron chelator and is widely used to treat iron overload in transfusion-dependent patients. Its once-daily dosing and oral route of administration have made it an appealing alternative to deferoxamine. Recent case studies have brought to light its potential to cause...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Greater Baltimore Medical Center
2019-07-01
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| Series: | Journal of Community Hospital Internal Medicine Perspectives |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/20009666.2019.1650592 |
| _version_ | 1797966003931447296 |
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| author | Iman Khan Mustafa Muhammad Janki Patel |
| author_facet | Iman Khan Mustafa Muhammad Janki Patel |
| author_sort | Iman Khan |
| collection | DOAJ |
| description | Deferasirox is a recently approved iron chelator and is widely used to treat iron overload in transfusion-dependent patients. Its once-daily dosing and oral route of administration have made it an appealing alternative to deferoxamine. Recent case studies have brought to light its potential to cause damage to the proximal convoluted tubule resulting in Fanconi syndrome (FS). FS is a proximal tubular dysfunction that leads to glycosuria, phosphaturia, aminoaciduria, and normal anion gap metabolic acidosis. Herein, we discuss a case of a young male on chronic blood transfusions requiring deferasirox therapy, who was found to have FS from its use. We discuss the possible mechanism of drug toxicity and the need for regular monitoring of serum electrolytes andurinalysis along with renal function tests to avoid this consequence. |
| first_indexed | 2024-04-11T02:08:53Z |
| format | Article |
| id | doaj.art-de0784367f164553b23cbae810a70447 |
| institution | Directory Open Access Journal |
| issn | 2000-9666 |
| language | English |
| last_indexed | 2024-04-11T02:08:53Z |
| publishDate | 2019-07-01 |
| publisher | Greater Baltimore Medical Center |
| record_format | Article |
| series | Journal of Community Hospital Internal Medicine Perspectives |
| spelling | doaj.art-de0784367f164553b23cbae810a704472023-01-03T02:35:42ZengGreater Baltimore Medical CenterJournal of Community Hospital Internal Medicine Perspectives2000-96662019-07-019435835910.1080/20009666.2019.16505921650592Deferasirox – a rarer cause of Fanconi syndromeIman Khan0Mustafa Muhammad1Janki Patel2Greater Baltimore Medical CenterGreater Baltimore Medical CenterGreater Baltimore Medical CenterDeferasirox is a recently approved iron chelator and is widely used to treat iron overload in transfusion-dependent patients. Its once-daily dosing and oral route of administration have made it an appealing alternative to deferoxamine. Recent case studies have brought to light its potential to cause damage to the proximal convoluted tubule resulting in Fanconi syndrome (FS). FS is a proximal tubular dysfunction that leads to glycosuria, phosphaturia, aminoaciduria, and normal anion gap metabolic acidosis. Herein, we discuss a case of a young male on chronic blood transfusions requiring deferasirox therapy, who was found to have FS from its use. We discuss the possible mechanism of drug toxicity and the need for regular monitoring of serum electrolytes andurinalysis along with renal function tests to avoid this consequence.http://dx.doi.org/10.1080/20009666.2019.1650592NephropathyelectrolytesFanconiproximal |
| spellingShingle | Iman Khan Mustafa Muhammad Janki Patel Deferasirox – a rarer cause of Fanconi syndrome Journal of Community Hospital Internal Medicine Perspectives Nephropathy electrolytes Fanconi proximal |
| title | Deferasirox – a rarer cause of Fanconi syndrome |
| title_full | Deferasirox – a rarer cause of Fanconi syndrome |
| title_fullStr | Deferasirox – a rarer cause of Fanconi syndrome |
| title_full_unstemmed | Deferasirox – a rarer cause of Fanconi syndrome |
| title_short | Deferasirox – a rarer cause of Fanconi syndrome |
| title_sort | deferasirox a rarer cause of fanconi syndrome |
| topic | Nephropathy electrolytes Fanconi proximal |
| url | http://dx.doi.org/10.1080/20009666.2019.1650592 |
| work_keys_str_mv | AT imankhan deferasiroxararercauseoffanconisyndrome AT mustafamuhammad deferasiroxararercauseoffanconisyndrome AT jankipatel deferasiroxararercauseoffanconisyndrome |