Failure of DNA double-strand break repair by tau mediates Alzheimer’s disease pathology in vitro
Phosphorylated microtubule-associated protein tau (p-tau) accumulates at double-strand breaks (DSBs) in neurons. Loss of tau induces failure of DSB repair and excessive DSB accumulation, leading to aberrant p-tau aggregation and apoptotic neurons.
Bibliographic Details
| Main Authors: |
Megumi Asada-Utsugi,
Kengo Uemura,
Takashi Ayaki,
Maiko T. Uemura,
Sumio Minamiyama,
Ryota Hikiami,
Toshifumi Morimura,
Akemi Shodai,
Takatoshi Ueki,
Ryosuke Takahashi,
Ayae Kinoshita,
Makoto Urushitani |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2022-04-01
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| Series: | Communications Biology
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| Online Access: | https://doi.org/10.1038/s42003-022-03312-0
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