Osteoimmunology of Spondyloarthritis
The mechanisms underlying the development of bone damage in the context of spondyloarthritis (SpA) are not completely understood. To date, a considerable amount of evidence indicates that several developmental pathways are crucially involved in osteoimmunology. The present review explores the biolog...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/19/14924 |
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| author | Angelo Fassio Fabiola Atzeni Maurizio Rossini Valeria D’Amico Francesco Cantatore Maria Sole Chimenti Chiara Crotti Bruno Frediani Andrea Giusti Giusy Peluso Guido Rovera Palma Scolieri Vincenzo Raimondo Davide Gatti on behalf of the Study Group on Osteoporosis and Skeletal Metabolic Diseases of the Italian Society of Rheumatology |
| author_facet | Angelo Fassio Fabiola Atzeni Maurizio Rossini Valeria D’Amico Francesco Cantatore Maria Sole Chimenti Chiara Crotti Bruno Frediani Andrea Giusti Giusy Peluso Guido Rovera Palma Scolieri Vincenzo Raimondo Davide Gatti on behalf of the Study Group on Osteoporosis and Skeletal Metabolic Diseases of the Italian Society of Rheumatology |
| author_sort | Angelo Fassio |
| collection | DOAJ |
| description | The mechanisms underlying the development of bone damage in the context of spondyloarthritis (SpA) are not completely understood. To date, a considerable amount of evidence indicates that several developmental pathways are crucially involved in osteoimmunology. The present review explores the biological mechanisms underlying the relationship between inflammatory dysregulation, structural progression, and osteoporosis in this diverse family of conditions. We summarize the current knowledge of bone biology and balance and the foundations of bone regulation, including bone morphogenetic protein, the Wnt pathway, and Hedgehog signaling, as well as the role of cytokines in the development of bone damage in SpA. Other areas surveyed include the pathobiology of bone damage and systemic bone loss (osteoporosis) in SpA and the effects of pharmacological treatment on focal bone damage. Lastly, we present data relative to a survey of bone metabolic assessment in SpA from Italian bone specialist rheumatology centers. The results confirm that most of the attention to bone health is given to postmenopausal subjects and that the aspect of metabolic bone health may still be underrepresented. In our opinion, it may be the time for a call to action to increase the interest in and focus on the diagnosis and management of SpA. |
| first_indexed | 2024-03-10T21:43:12Z |
| format | Article |
| id | doaj.art-de0c55aa9259464088f9a4233253b9ef |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T21:43:12Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-de0c55aa9259464088f9a4233253b9ef2023-11-19T14:32:38ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-10-0124191492410.3390/ijms241914924Osteoimmunology of SpondyloarthritisAngelo Fassio0Fabiola Atzeni1Maurizio Rossini2Valeria D’Amico3Francesco Cantatore4Maria Sole Chimenti5Chiara Crotti6Bruno Frediani7Andrea Giusti8Giusy Peluso9Guido Rovera10Palma Scolieri11Vincenzo Raimondo12Davide Gatti13on behalf of the Study Group on Osteoporosis and Skeletal Metabolic Diseases of the Italian Society of RheumatologyDipartimento di Medicina, Università di Verona, 37124 Verona, ItalyUnità Operativa Complessa di Reumatologia Azienda Ospedaliero Universitaria Policlinico “G. Martino” di Messina, 35128 Messina, ItalyDipartimento di Medicina, Università di Verona, 37124 Verona, ItalyUnità Operativa Complessa di Reumatologia Azienda Ospedaliero Universitaria Policlinico “G. Martino” di Messina, 35128 Messina, ItalyUnità Operativa Complessa di Reumatologia Universitaria, Polic. “Riuniti” di Foggia, 71122 Foggia, ItalyDipartimento di Medicina dei Sistemi, Reumatologia, Allergologia e Immunologia Clinica Università di Roma Tor Vergata, 00133 Rome, ItalyUOC Osteoporosi e Malattie Metaboliche dell’Osso Dipartimento di Reumatologia e Scienze Mediche ASST-G. Pini-CTO, 20122 Milan, ItalyDepartment of Medical, Surgical and Neuroscience Sciences, Rheumatology University of Siena, 53100 Siena, ItalySSD Malattie Reumatologiche e del Metabolismo Osseo, Dipartimento delle Specialità Mediche, ASL3, 16132 Genova, ItalyUOC di Reumatologia-Fondazione Policlinico Universitario Agostino Gemelli-IRCSS, 00168 Rome, ItalyOspedale S. Andrea, Divisione Reumatologia, 13100 Vercelli, ItalyAmbulatorio di Reumatologia Ospedale Nuovo Regina Margherita ASL ROMA1, 00153 Rome, ItalyCasa di Cura Madonna dello Scoglio, 88836 Crotone, ItalyDipartimento di Medicina, Università di Verona, 37124 Verona, ItalyThe mechanisms underlying the development of bone damage in the context of spondyloarthritis (SpA) are not completely understood. To date, a considerable amount of evidence indicates that several developmental pathways are crucially involved in osteoimmunology. The present review explores the biological mechanisms underlying the relationship between inflammatory dysregulation, structural progression, and osteoporosis in this diverse family of conditions. We summarize the current knowledge of bone biology and balance and the foundations of bone regulation, including bone morphogenetic protein, the Wnt pathway, and Hedgehog signaling, as well as the role of cytokines in the development of bone damage in SpA. Other areas surveyed include the pathobiology of bone damage and systemic bone loss (osteoporosis) in SpA and the effects of pharmacological treatment on focal bone damage. Lastly, we present data relative to a survey of bone metabolic assessment in SpA from Italian bone specialist rheumatology centers. The results confirm that most of the attention to bone health is given to postmenopausal subjects and that the aspect of metabolic bone health may still be underrepresented. In our opinion, it may be the time for a call to action to increase the interest in and focus on the diagnosis and management of SpA.https://www.mdpi.com/1422-0067/24/19/14924osteoimmunologyspondyloarthritispathophysiology |
| spellingShingle | Angelo Fassio Fabiola Atzeni Maurizio Rossini Valeria D’Amico Francesco Cantatore Maria Sole Chimenti Chiara Crotti Bruno Frediani Andrea Giusti Giusy Peluso Guido Rovera Palma Scolieri Vincenzo Raimondo Davide Gatti on behalf of the Study Group on Osteoporosis and Skeletal Metabolic Diseases of the Italian Society of Rheumatology Osteoimmunology of Spondyloarthritis International Journal of Molecular Sciences osteoimmunology spondyloarthritis pathophysiology |
| title | Osteoimmunology of Spondyloarthritis |
| title_full | Osteoimmunology of Spondyloarthritis |
| title_fullStr | Osteoimmunology of Spondyloarthritis |
| title_full_unstemmed | Osteoimmunology of Spondyloarthritis |
| title_short | Osteoimmunology of Spondyloarthritis |
| title_sort | osteoimmunology of spondyloarthritis |
| topic | osteoimmunology spondyloarthritis pathophysiology |
| url | https://www.mdpi.com/1422-0067/24/19/14924 |
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