The Effect of Group Training or Spinal Orthosis on Quality of Life and Potential Plasma Markers of Pain in Older Women With Osteoporosis. A Randomized Controlled Trial
Objective: Primary purpose was to examine the effects of exercise and use of a spinal orthosis on quality of life (QoL). Secondary, to explore the effects of above-mentioned interventions on plasma levels of potential markers of pain: substance P (SP), calcitonin gene-related peptide (CGRP), and int...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-12-01
|
| Series: | Archives of Rehabilitation Research and Clinical Translation |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590109523000599 |
| _version_ | 1797398999556161536 |
|---|---|
| author | Elin Uzunel, MD Ann-Charlotte Grahn Kronhed, RPT, PhD Christina Kaijser Alin, RPT, PhD Aisha Siddiqah Ahmed, PhD Per Wändell, MD, PhD Helena Salminen, MD, PhD |
| author_facet | Elin Uzunel, MD Ann-Charlotte Grahn Kronhed, RPT, PhD Christina Kaijser Alin, RPT, PhD Aisha Siddiqah Ahmed, PhD Per Wändell, MD, PhD Helena Salminen, MD, PhD |
| author_sort | Elin Uzunel, MD |
| collection | DOAJ |
| description | Objective: Primary purpose was to examine the effects of exercise and use of a spinal orthosis on quality of life (QoL). Secondary, to explore the effects of above-mentioned interventions on plasma levels of potential markers of pain: substance P (SP), calcitonin gene-related peptide (CGRP), and interleukin-6 (IL-6). Design: Randomized controlled trial. Setting: Community-dwelling women in Stockholm. Participants: A total of 113 women aged 60-93 years suffering from back pain and self-reported osteoporosis (n=113). Interventions: The randomized controlled trial was 3-armed: participation in an equipment exercise group, treatment with an activating spinal orthosis or controls. The intervention time was 6 months. Main Outcome Measure(s): QoL (QUALEFFO-41 and SF-36), plasma levels of SP, CGRP, and IL-6 measured at baseline and after 6 months in all 3 arms. Results: No improvement of QoL was found. Comparing change in mobility (QUALEFFO-41), the effect in least squares means was lower in the spinal orthosis group compared with controls. In the exercise group, the role emotional score (SF-36) deteriorated during the intervention. Effect size varied between 0.02 and 0.6. There was no change in the levels of CGRP or SP, while IL-6 levels were lower at 6 months in the spinal orthosis group compared with the other groups. At least 1 previous vertebral fracture was verified by X-ray in 46 women. Conclusion: The interventions showed none or negative effect on QoL, which was unexpected. The modest effect size may prompt a cautious interpretation. We found a lowering of IL-6 levels in the spinal orthosis group, but more studies are needed. |
| first_indexed | 2024-03-09T01:34:39Z |
| format | Article |
| id | doaj.art-de0cb2e113b84342b21f876d740aba87 |
| institution | Directory Open Access Journal |
| issn | 2590-1095 |
| language | English |
| last_indexed | 2024-03-09T01:34:39Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Archives of Rehabilitation Research and Clinical Translation |
| spelling | doaj.art-de0cb2e113b84342b21f876d740aba872023-12-09T06:07:39ZengElsevierArchives of Rehabilitation Research and Clinical Translation2590-10952023-12-0154100297The Effect of Group Training or Spinal Orthosis on Quality of Life and Potential Plasma Markers of Pain in Older Women With Osteoporosis. A Randomized Controlled TrialElin Uzunel, MD0Ann-Charlotte Grahn Kronhed, RPT, PhD1Christina Kaijser Alin, RPT, PhD2Aisha Siddiqah Ahmed, PhD3Per Wändell, MD, PhD4Helena Salminen, MD, PhD5Division of Family Medicine and Primary Care, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden; Academic Primary Health Care Centre, Stockholm, Sweden; Corresponding author Elin Uzunel, Division of Family Medicine and Primary Care, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Alfred Nobels allé 23, 14183 Huddinge, Stockholm, Sweden.Division of Prevention, Rehabilitation and Community Medicine, Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, SwedenDivision of Family Medicine and Primary Care, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, SwedenDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, SwedenDivision of Family Medicine and Primary Care, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, SwedenDivision of Family Medicine and Primary Care, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden; Academic Primary Health Care Centre, Stockholm, SwedenObjective: Primary purpose was to examine the effects of exercise and use of a spinal orthosis on quality of life (QoL). Secondary, to explore the effects of above-mentioned interventions on plasma levels of potential markers of pain: substance P (SP), calcitonin gene-related peptide (CGRP), and interleukin-6 (IL-6). Design: Randomized controlled trial. Setting: Community-dwelling women in Stockholm. Participants: A total of 113 women aged 60-93 years suffering from back pain and self-reported osteoporosis (n=113). Interventions: The randomized controlled trial was 3-armed: participation in an equipment exercise group, treatment with an activating spinal orthosis or controls. The intervention time was 6 months. Main Outcome Measure(s): QoL (QUALEFFO-41 and SF-36), plasma levels of SP, CGRP, and IL-6 measured at baseline and after 6 months in all 3 arms. Results: No improvement of QoL was found. Comparing change in mobility (QUALEFFO-41), the effect in least squares means was lower in the spinal orthosis group compared with controls. In the exercise group, the role emotional score (SF-36) deteriorated during the intervention. Effect size varied between 0.02 and 0.6. There was no change in the levels of CGRP or SP, while IL-6 levels were lower at 6 months in the spinal orthosis group compared with the other groups. At least 1 previous vertebral fracture was verified by X-ray in 46 women. Conclusion: The interventions showed none or negative effect on QoL, which was unexpected. The modest effect size may prompt a cautious interpretation. We found a lowering of IL-6 levels in the spinal orthosis group, but more studies are needed.http://www.sciencedirect.com/science/article/pii/S2590109523000599BiomarkersOsteoporosisPainQuality of lifeRehabilitationWomen |
| spellingShingle | Elin Uzunel, MD Ann-Charlotte Grahn Kronhed, RPT, PhD Christina Kaijser Alin, RPT, PhD Aisha Siddiqah Ahmed, PhD Per Wändell, MD, PhD Helena Salminen, MD, PhD The Effect of Group Training or Spinal Orthosis on Quality of Life and Potential Plasma Markers of Pain in Older Women With Osteoporosis. A Randomized Controlled Trial Archives of Rehabilitation Research and Clinical Translation Biomarkers Osteoporosis Pain Quality of life Rehabilitation Women |
| title | The Effect of Group Training or Spinal Orthosis on Quality of Life and Potential Plasma Markers of Pain in Older Women With Osteoporosis. A Randomized Controlled Trial |
| title_full | The Effect of Group Training or Spinal Orthosis on Quality of Life and Potential Plasma Markers of Pain in Older Women With Osteoporosis. A Randomized Controlled Trial |
| title_fullStr | The Effect of Group Training or Spinal Orthosis on Quality of Life and Potential Plasma Markers of Pain in Older Women With Osteoporosis. A Randomized Controlled Trial |
| title_full_unstemmed | The Effect of Group Training or Spinal Orthosis on Quality of Life and Potential Plasma Markers of Pain in Older Women With Osteoporosis. A Randomized Controlled Trial |
| title_short | The Effect of Group Training or Spinal Orthosis on Quality of Life and Potential Plasma Markers of Pain in Older Women With Osteoporosis. A Randomized Controlled Trial |
| title_sort | effect of group training or spinal orthosis on quality of life and potential plasma markers of pain in older women with osteoporosis a randomized controlled trial |
| topic | Biomarkers Osteoporosis Pain Quality of life Rehabilitation Women |
| url | http://www.sciencedirect.com/science/article/pii/S2590109523000599 |
| work_keys_str_mv | AT elinuzunelmd theeffectofgrouptrainingorspinalorthosisonqualityoflifeandpotentialplasmamarkersofpaininolderwomenwithosteoporosisarandomizedcontrolledtrial AT anncharlottegrahnkronhedrptphd theeffectofgrouptrainingorspinalorthosisonqualityoflifeandpotentialplasmamarkersofpaininolderwomenwithosteoporosisarandomizedcontrolledtrial AT christinakaijseralinrptphd theeffectofgrouptrainingorspinalorthosisonqualityoflifeandpotentialplasmamarkersofpaininolderwomenwithosteoporosisarandomizedcontrolledtrial AT aishasiddiqahahmedphd theeffectofgrouptrainingorspinalorthosisonqualityoflifeandpotentialplasmamarkersofpaininolderwomenwithosteoporosisarandomizedcontrolledtrial AT perwandellmdphd theeffectofgrouptrainingorspinalorthosisonqualityoflifeandpotentialplasmamarkersofpaininolderwomenwithosteoporosisarandomizedcontrolledtrial AT helenasalminenmdphd theeffectofgrouptrainingorspinalorthosisonqualityoflifeandpotentialplasmamarkersofpaininolderwomenwithosteoporosisarandomizedcontrolledtrial AT elinuzunelmd effectofgrouptrainingorspinalorthosisonqualityoflifeandpotentialplasmamarkersofpaininolderwomenwithosteoporosisarandomizedcontrolledtrial AT anncharlottegrahnkronhedrptphd effectofgrouptrainingorspinalorthosisonqualityoflifeandpotentialplasmamarkersofpaininolderwomenwithosteoporosisarandomizedcontrolledtrial AT christinakaijseralinrptphd effectofgrouptrainingorspinalorthosisonqualityoflifeandpotentialplasmamarkersofpaininolderwomenwithosteoporosisarandomizedcontrolledtrial AT aishasiddiqahahmedphd effectofgrouptrainingorspinalorthosisonqualityoflifeandpotentialplasmamarkersofpaininolderwomenwithosteoporosisarandomizedcontrolledtrial AT perwandellmdphd effectofgrouptrainingorspinalorthosisonqualityoflifeandpotentialplasmamarkersofpaininolderwomenwithosteoporosisarandomizedcontrolledtrial AT helenasalminenmdphd effectofgrouptrainingorspinalorthosisonqualityoflifeandpotentialplasmamarkersofpaininolderwomenwithosteoporosisarandomizedcontrolledtrial |