Effect of <i>Sodium Hyaluronate</i> on Antioxidant and Anti-Ageing Activities in <i>Caenorhabditis elegans</i>
As an acidic polysaccharide, the formation of <i>Hyaluronic acid</i> (HA) is typically <i>Sodium Hyaluronate</i> (SH) for knee repair, oral treatment, skincare and as a food additive. Nevertheless, little information is available on the anti-ageing activity of SH as a food ad...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Foods |
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| Online Access: | https://www.mdpi.com/2304-8158/12/7/1400 |
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| author | Qianmin Lin Bingbing Song Yingxiong Zhong Huan Yin Ziyu Li Zhuo Wang Kit-Leong Cheong Riming Huang Saiyi Zhong |
| author_facet | Qianmin Lin Bingbing Song Yingxiong Zhong Huan Yin Ziyu Li Zhuo Wang Kit-Leong Cheong Riming Huang Saiyi Zhong |
| author_sort | Qianmin Lin |
| collection | DOAJ |
| description | As an acidic polysaccharide, the formation of <i>Hyaluronic acid</i> (HA) is typically <i>Sodium Hyaluronate</i> (SH) for knee repair, oral treatment, skincare and as a food additive. Nevertheless, little information is available on the anti-ageing activity of SH as a food additive. Therefore, we treated <i>C. elegans</i> with SH, then inferred the anti-aging activity of SH by examining the lifespan physiological indicators and senescence-associated gene expression. Compared with the control group, SH (800 μg/mL) prolonged the <i>C. elegans</i>’ lifespans in regular, 35 °C and H<sub>2</sub>O<sub>2</sub> environment by 0.27-fold, 0.25-fold and 1.17-fold. Simultaneously, glutathione peroxidase (GSH-Px), antioxidant enzyme superoxide dismutase (SOD) and catalase (CAT) were increased by 8.6%, 0.36% and 167%. However, lipofuscin accumulation, reactive oxygen species (ROS) and malondialdehyde (MDA) were decreased by 36%, 47.8–65.7% and 9.5–13.1%. After SH treatment, athletic ability was improved and no impairment of reproductive capacity was seen. In addition, SH inhibited the blocking effect of <i>age-1</i> and up-regulated gene levels involving <i>daf-16</i>, <i>sod-3</i>, <i>gst-4</i> and <i>skn-1</i>. In conclusion, SH provides potential applications in anti-ageing and anti-oxidation and regulates physiological function. |
| first_indexed | 2024-03-11T05:38:13Z |
| format | Article |
| id | doaj.art-de0ce538b2df4668bab9a1678856b7b8 |
| institution | Directory Open Access Journal |
| issn | 2304-8158 |
| language | English |
| last_indexed | 2024-03-11T05:38:13Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj.art-de0ce538b2df4668bab9a1678856b7b82023-11-17T16:40:46ZengMDPI AGFoods2304-81582023-03-01127140010.3390/foods12071400Effect of <i>Sodium Hyaluronate</i> on Antioxidant and Anti-Ageing Activities in <i>Caenorhabditis elegans</i>Qianmin Lin0Bingbing Song1Yingxiong Zhong2Huan Yin3Ziyu Li4Zhuo Wang5Kit-Leong Cheong6Riming Huang7Saiyi Zhong8College of Food Science and Technology, Guangdong Ocean University, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Zhanjiang 524088, ChinaCollege of Food Science and Technology, Guangdong Ocean University, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Zhanjiang 524088, ChinaCollege of Food Science and Technology, Guangdong Ocean University, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Zhanjiang 524088, ChinaCollege of Food Science and Technology, Guangdong Ocean University, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Zhanjiang 524088, ChinaCollege of Food Science and Technology, Guangdong Ocean University, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Zhanjiang 524088, ChinaCollege of Food Science and Technology, Guangdong Ocean University, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Zhanjiang 524088, ChinaCollege of Food Science and Technology, Guangdong Ocean University, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Zhanjiang 524088, ChinaCollege of Food Science, South China Agricultural University, Guangzhou 510642, ChinaCollege of Food Science and Technology, Guangdong Ocean University, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Zhanjiang 524088, ChinaAs an acidic polysaccharide, the formation of <i>Hyaluronic acid</i> (HA) is typically <i>Sodium Hyaluronate</i> (SH) for knee repair, oral treatment, skincare and as a food additive. Nevertheless, little information is available on the anti-ageing activity of SH as a food additive. Therefore, we treated <i>C. elegans</i> with SH, then inferred the anti-aging activity of SH by examining the lifespan physiological indicators and senescence-associated gene expression. Compared with the control group, SH (800 μg/mL) prolonged the <i>C. elegans</i>’ lifespans in regular, 35 °C and H<sub>2</sub>O<sub>2</sub> environment by 0.27-fold, 0.25-fold and 1.17-fold. Simultaneously, glutathione peroxidase (GSH-Px), antioxidant enzyme superoxide dismutase (SOD) and catalase (CAT) were increased by 8.6%, 0.36% and 167%. However, lipofuscin accumulation, reactive oxygen species (ROS) and malondialdehyde (MDA) were decreased by 36%, 47.8–65.7% and 9.5–13.1%. After SH treatment, athletic ability was improved and no impairment of reproductive capacity was seen. In addition, SH inhibited the blocking effect of <i>age-1</i> and up-regulated gene levels involving <i>daf-16</i>, <i>sod-3</i>, <i>gst-4</i> and <i>skn-1</i>. In conclusion, SH provides potential applications in anti-ageing and anti-oxidation and regulates physiological function.https://www.mdpi.com/2304-8158/12/7/1400<i>Sodium Hyaluronate</i><i>Caenorhabditis elegans</i>anti-ageingoxidative stressantioxidant enzymes |
| spellingShingle | Qianmin Lin Bingbing Song Yingxiong Zhong Huan Yin Ziyu Li Zhuo Wang Kit-Leong Cheong Riming Huang Saiyi Zhong Effect of <i>Sodium Hyaluronate</i> on Antioxidant and Anti-Ageing Activities in <i>Caenorhabditis elegans</i> Foods <i>Sodium Hyaluronate</i> <i>Caenorhabditis elegans</i> anti-ageing oxidative stress antioxidant enzymes |
| title | Effect of <i>Sodium Hyaluronate</i> on Antioxidant and Anti-Ageing Activities in <i>Caenorhabditis elegans</i> |
| title_full | Effect of <i>Sodium Hyaluronate</i> on Antioxidant and Anti-Ageing Activities in <i>Caenorhabditis elegans</i> |
| title_fullStr | Effect of <i>Sodium Hyaluronate</i> on Antioxidant and Anti-Ageing Activities in <i>Caenorhabditis elegans</i> |
| title_full_unstemmed | Effect of <i>Sodium Hyaluronate</i> on Antioxidant and Anti-Ageing Activities in <i>Caenorhabditis elegans</i> |
| title_short | Effect of <i>Sodium Hyaluronate</i> on Antioxidant and Anti-Ageing Activities in <i>Caenorhabditis elegans</i> |
| title_sort | effect of i sodium hyaluronate i on antioxidant and anti ageing activities in i caenorhabditis elegans i |
| topic | <i>Sodium Hyaluronate</i> <i>Caenorhabditis elegans</i> anti-ageing oxidative stress antioxidant enzymes |
| url | https://www.mdpi.com/2304-8158/12/7/1400 |
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