Ubiquitination Regulates the Morphogenesis and Function of Sperm Organelles
It is now understood that protein ubiquitination has diverse cellular functions in eukaryotes. The molecular mechanism and physiological significance of ubiquitin-mediated processes have been extensively studied in yeast, Drosophila and mammalian somatic cells. Moreover, an increasing number of stud...
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| Format: | Article |
| Language: | English |
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MDPI AG
2013-12-01
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| Series: | Cells |
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| Online Access: | http://www.mdpi.com/2073-4409/2/4/732 |
| _version_ | 1797713654329638912 |
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| author | Nobuhiro Nakamura |
| author_facet | Nobuhiro Nakamura |
| author_sort | Nobuhiro Nakamura |
| collection | DOAJ |
| description | It is now understood that protein ubiquitination has diverse cellular functions in eukaryotes. The molecular mechanism and physiological significance of ubiquitin-mediated processes have been extensively studied in yeast, Drosophila and mammalian somatic cells. Moreover, an increasing number of studies have emphasized the importance of ubiquitination in spermatogenesis and fertilization. The dysfunction of various ubiquitin systems results in impaired sperm development with abnormal organelle morphology and function, which in turn is highly associated with male infertility. This review will focus on the emerging roles of ubiquitination in biogenesis, function and stability of sperm organelles in mammals. |
| first_indexed | 2024-03-12T07:39:54Z |
| format | Article |
| id | doaj.art-de0cfd870d504d50b7cefea37fc35c92 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T07:39:54Z |
| publishDate | 2013-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-de0cfd870d504d50b7cefea37fc35c922023-09-02T21:24:42ZengMDPI AGCells2073-44092013-12-012473275010.3390/cells2040732cells2040732Ubiquitination Regulates the Morphogenesis and Function of Sperm OrganellesNobuhiro Nakamura0Department of Biological Sciences, Tokyo Institute of Technology, 4259-B13 Nagatsuta-cho, Midori-ku, Yokohama 226-8501, JapanIt is now understood that protein ubiquitination has diverse cellular functions in eukaryotes. The molecular mechanism and physiological significance of ubiquitin-mediated processes have been extensively studied in yeast, Drosophila and mammalian somatic cells. Moreover, an increasing number of studies have emphasized the importance of ubiquitination in spermatogenesis and fertilization. The dysfunction of various ubiquitin systems results in impaired sperm development with abnormal organelle morphology and function, which in turn is highly associated with male infertility. This review will focus on the emerging roles of ubiquitination in biogenesis, function and stability of sperm organelles in mammals.http://www.mdpi.com/2073-4409/2/4/732acrosomedeubiquitinationhistonemembrane traffickingmitochondriamitophagyspermatogenesisspermiogenesisubiquitination |
| spellingShingle | Nobuhiro Nakamura Ubiquitination Regulates the Morphogenesis and Function of Sperm Organelles Cells acrosome deubiquitination histone membrane trafficking mitochondria mitophagy spermatogenesis spermiogenesis ubiquitination |
| title | Ubiquitination Regulates the Morphogenesis and Function of Sperm Organelles |
| title_full | Ubiquitination Regulates the Morphogenesis and Function of Sperm Organelles |
| title_fullStr | Ubiquitination Regulates the Morphogenesis and Function of Sperm Organelles |
| title_full_unstemmed | Ubiquitination Regulates the Morphogenesis and Function of Sperm Organelles |
| title_short | Ubiquitination Regulates the Morphogenesis and Function of Sperm Organelles |
| title_sort | ubiquitination regulates the morphogenesis and function of sperm organelles |
| topic | acrosome deubiquitination histone membrane trafficking mitochondria mitophagy spermatogenesis spermiogenesis ubiquitination |
| url | http://www.mdpi.com/2073-4409/2/4/732 |
| work_keys_str_mv | AT nobuhironakamura ubiquitinationregulatesthemorphogenesisandfunctionofspermorganelles |