Autotaxin signaling facilitates β cell dedifferentiation and dysfunction induced by Sirtuin 3 deficiency

Autotaxin signaling facilitates β cell dedifferentiation and dysfunction induced by Sirtuin 3 deficiency

Objective: β cell dedifferentiation may underlie the reversible reduction in pancreatic β cell mass and function in type 2 diabetes (T2D). We previously reported that β cell-specific Sirt3 knockout (Sirt3f/f;Cre/+) mice developed impaired glucose tolerance and glucose-stimulated insulin secretion af...

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Bibliographic Details
Main Authors: Huanyi Cao, Arthur C.K. Chung, Xing Ming, Dandan Mao, Heung Man Lee, Xiaoyun Cao, Guy A. Rutter, Juliana C.N. Chan, Xiao Yu Tian, Alice P.S. Kong
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Molecular Metabolism
Subjects:
Autotaxin
Lysophosphatidic acid
β cell dedifferentiation
Sirtuin3
Mitogen-activated protein kinases
Type 2 diabetes
Online Access:http://www.sciencedirect.com/science/article/pii/S221287782200062X

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http://www.sciencedirect.com/science/article/pii/S221287782200062X

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