Correlation of Gamma Glutamyl Transferase with Traditional Risk Markers of Cardiovascular Disease in Different Obesity Phenotypes
Introduction: The increased prevalence of overweight, obesity, and metabolic syndrome has revealed that liver enzymes have a potential role as determinants of metabolic conditions such as, hyperlipidemia, and Cardiovascular Disease (CVD). Aim: The study aimed to investigate the correlation betwe...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2021-04-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://www.jcdr.net/articles/PDF/14801/48020_CE[Ra1]_F(SHU)_PF1(AsG_OM)_PFA(AsG_KM)_PN(KM).pdf |
| Summary: | Introduction: The increased prevalence of overweight, obesity,
and metabolic syndrome has revealed that liver enzymes have a
potential role as determinants of metabolic conditions such as,
hyperlipidemia, and Cardiovascular Disease (CVD).
Aim: The study aimed to investigate the correlation between
liver enzymes with anthropometric indices of obesity and lipid
profile in different obese phenotypes at a tertiary care.
Materials and Methods: The present observational study was
conducted on a total of 180 obese participants of either gender
in the age group 18-59 years for a from December 2018 to May
2019. These were further divided into two phenotypic groups
viz., Metabolically Healthy Obese (MHO group; n=90) and
Metabolically Unhealthy Obese (MUHO group; n=90) according
to National Cholesterol Education Program (NCEP) Adult
Treatment Panel III (ATP) criteria. Traditional cardiovascular
risk factors were evaluated in the study participants through
anthropometric viz., Body Mass Index (BMI), Waist Circumference
(WC), Hip Circumference (HC), Waist–Hip Ratio (WHR), blood
pressure and biochemical investigations i.e., serum glucose,
lipid profile and liver enzymes. Data was analysed by using
Microsoft excel software.
Results: Among 180 obese participants, 76 were males and 104
females with mean age 40.42±10.84 years. In MUHO phenotype,
Gamma Glutamyl Transferase (GGT) showed a strong positive
correlation with BMI (r=0.413, p=0.00001), lipid parameters
viz., LDL-C (r=0.3785, p=0.0001), TC (r=0.2953, p=0.0023), TG
(r=0.2623, p=0.006) and negative correlation with HDL-C (-r=0.3167,
p=0.0011). No significant correlation was found in MHO phenotype
between liver enzymes, BMI and lipid profile parameters.
Conclusion: The results of this study indicated that GGT
shows a strong positive correlation with traditional risk factors
in MUHO participants. Thus, raised GGT may be considered as
a risk marker of CVD in MUHO phenotype. |
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| ISSN: | 2249-782X 0973-709X |