Differential Long-Chain Polyunsaturated Fatty Acids Status and Placental Transport in Adolescent Pregnancies
Adolescent pregnancy increases risk of adverse perinatal outcomes. Placental delivery of long-chain polyunsaturated fatty acids (LCPUFA) is essential for fetal growth and development. In this pilot study, we aimed to assess maternal and fetal status of fatty acids (FA) measured at birth and the expr...
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MDPI AG
2018-02-01
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author | Fernanda Carrilho Pinto da Fonseca Daniela de Barros Mucci Renata Pereira Assumpção Henrique Marcondes Fátima Lúcia de Carvalho Sardinha Simone Vargas Silva Marta Citelli Maria das Graças Tavares do Carmo |
author_facet | Fernanda Carrilho Pinto da Fonseca Daniela de Barros Mucci Renata Pereira Assumpção Henrique Marcondes Fátima Lúcia de Carvalho Sardinha Simone Vargas Silva Marta Citelli Maria das Graças Tavares do Carmo |
author_sort | Fernanda Carrilho Pinto da Fonseca |
collection | DOAJ |
description | Adolescent pregnancy increases risk of adverse perinatal outcomes. Placental delivery of long-chain polyunsaturated fatty acids (LCPUFA) is essential for fetal growth and development. In this pilot study, we aimed to assess maternal and fetal status of fatty acids (FA) measured at birth and the expression of key genes involved in FA uptake, transport and metabolism in the placenta of fifteen adolescents and fifteen adults. FA were quantified by gas-liquid chromatography. Placental expression of FA transporters was assessed by quantitative real-time polymerase chain reaction (qRT-PCR) and peroxisome proliferator-activated receptor gamma (PPARγ) was quantified by Western Blot. Adolescents had lower docosahexaenoic acid (DHA, 22:6 n-3) and total n-3 FA levels in maternal erythrocytes and placenta, but these were not different in fetal erythrocytes. Arachidonic acid (AA, 20:4 n-6) concentration was increased in placenta but lower in fetal circulation. Plasma membrane fatty acid binding protein (FABPpm) and fatty acid transport protein (FATP) 4 mRNA expressions were not different, however FATP1, fatty acid translocase (FAT/CD36) and fatty acid binding protein 3 (FABP3) mRNA and PPARγ protein levels were decreased in placenta of adolescents. Despite significant downregulation of FATP1, CD36 and FABP3, there was only a modest decrease in LCPUFA (10%) and AA (12%) and no difference in DHA content in cord blood, suggesting that FA transfer to the fetus was partially protected by other factors in adolescents from this cohort. |
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language | English |
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publishDate | 2018-02-01 |
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series | Nutrients |
spelling | doaj.art-de1075d2925b4721926f04c0865c74ed2022-12-22T02:47:08ZengMDPI AGNutrients2072-66432018-02-0110222010.3390/nu10020220nu10020220Differential Long-Chain Polyunsaturated Fatty Acids Status and Placental Transport in Adolescent PregnanciesFernanda Carrilho Pinto da Fonseca0Daniela de Barros Mucci1Renata Pereira Assumpção2Henrique Marcondes3Fátima Lúcia de Carvalho Sardinha4Simone Vargas Silva5Marta Citelli6Maria das Graças Tavares do Carmo7Instituto de Nutrição Josué de Castro, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, BrazilInstituto de Nutrição Josué de Castro, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, BrazilInstituto de Nutrição Josué de Castro, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, BrazilInstituto de Nutrição Josué de Castro, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, BrazilInstituto de Nutrição Josué de Castro, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, BrazilInstituto de Biologia Roberto Alcantara Gomes, Universidade do Estado do Rio de Janeiro, Rio de Janeiro 20551-030, BrazilInstituto de Nutrição, Universidade do Estado do Rio de Janeiro, Rio de Janeiro 20559-900, BrazilInstituto de Nutrição Josué de Castro, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, BrazilAdolescent pregnancy increases risk of adverse perinatal outcomes. Placental delivery of long-chain polyunsaturated fatty acids (LCPUFA) is essential for fetal growth and development. In this pilot study, we aimed to assess maternal and fetal status of fatty acids (FA) measured at birth and the expression of key genes involved in FA uptake, transport and metabolism in the placenta of fifteen adolescents and fifteen adults. FA were quantified by gas-liquid chromatography. Placental expression of FA transporters was assessed by quantitative real-time polymerase chain reaction (qRT-PCR) and peroxisome proliferator-activated receptor gamma (PPARγ) was quantified by Western Blot. Adolescents had lower docosahexaenoic acid (DHA, 22:6 n-3) and total n-3 FA levels in maternal erythrocytes and placenta, but these were not different in fetal erythrocytes. Arachidonic acid (AA, 20:4 n-6) concentration was increased in placenta but lower in fetal circulation. Plasma membrane fatty acid binding protein (FABPpm) and fatty acid transport protein (FATP) 4 mRNA expressions were not different, however FATP1, fatty acid translocase (FAT/CD36) and fatty acid binding protein 3 (FABP3) mRNA and PPARγ protein levels were decreased in placenta of adolescents. Despite significant downregulation of FATP1, CD36 and FABP3, there was only a modest decrease in LCPUFA (10%) and AA (12%) and no difference in DHA content in cord blood, suggesting that FA transfer to the fetus was partially protected by other factors in adolescents from this cohort.http://www.mdpi.com/2072-6643/10/2/220polyunsaturated fatty acidsplacentafatty acid transport proteinadolescentsnewbornsumbilical cord |
spellingShingle | Fernanda Carrilho Pinto da Fonseca Daniela de Barros Mucci Renata Pereira Assumpção Henrique Marcondes Fátima Lúcia de Carvalho Sardinha Simone Vargas Silva Marta Citelli Maria das Graças Tavares do Carmo Differential Long-Chain Polyunsaturated Fatty Acids Status and Placental Transport in Adolescent Pregnancies Nutrients polyunsaturated fatty acids placenta fatty acid transport protein adolescents newborns umbilical cord |
title | Differential Long-Chain Polyunsaturated Fatty Acids Status and Placental Transport in Adolescent Pregnancies |
title_full | Differential Long-Chain Polyunsaturated Fatty Acids Status and Placental Transport in Adolescent Pregnancies |
title_fullStr | Differential Long-Chain Polyunsaturated Fatty Acids Status and Placental Transport in Adolescent Pregnancies |
title_full_unstemmed | Differential Long-Chain Polyunsaturated Fatty Acids Status and Placental Transport in Adolescent Pregnancies |
title_short | Differential Long-Chain Polyunsaturated Fatty Acids Status and Placental Transport in Adolescent Pregnancies |
title_sort | differential long chain polyunsaturated fatty acids status and placental transport in adolescent pregnancies |
topic | polyunsaturated fatty acids placenta fatty acid transport protein adolescents newborns umbilical cord |
url | http://www.mdpi.com/2072-6643/10/2/220 |
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