Gait Speed and Mood, Cognition, and Quality of Life in Older Adults With Atrial Fibrillation
Background Low gait speed has been linked with impaired mood, cognition, and quality of life (QOL) in older adults. We examined whether low gait speed was associated with impaired mood, cognition, and QOL among older adults with atrial fibrillation (AF). Methods and Results Participants (n=1185) had...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-11-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.119.013212 |
| _version_ | 1819205541597020160 |
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| author | Francesca R. Marino Darleen M. Lessard Jane S. Saczynski David D. McManus Luke G. Silverman‐Lloyd Christopher M. Benson Michael J. Blaha Molly E. Waring |
| author_facet | Francesca R. Marino Darleen M. Lessard Jane S. Saczynski David D. McManus Luke G. Silverman‐Lloyd Christopher M. Benson Michael J. Blaha Molly E. Waring |
| author_sort | Francesca R. Marino |
| collection | DOAJ |
| description | Background Low gait speed has been linked with impaired mood, cognition, and quality of life (QOL) in older adults. We examined whether low gait speed was associated with impaired mood, cognition, and QOL among older adults with atrial fibrillation (AF). Methods and Results Participants (n=1185) had a diagnosis of AF, aged ≥65 years, CHA2DS2VASc ≥2 and had no contraindications to anticoagulation. Participants completed a 15‐foot walk test, and low gait speed was categorized using cutoffs from the Fried Frailty Index. Participants self‐reported measures of depressive symptoms (Patient Health Questionnaire 9 ≥10), anxiety symptoms (Generalized Anxiety Disorder 7 ≥10), cognitive impairment (Montreal Cognitive Assessment ≤23), and potentially impaired Atrial Fibrillation Effect Quality‐of‐Life Questionnaire <80. Participants were on average aged 75.3 (SD: 7.0) years, 48.0% were women, and 85.5% were non‐Hispanic white; 85.6% were taking an oral anticoagulant, 26.1% had low gait speed, 8.4% had elevated depressive symptoms, 5.7% had elevated anxiety symptoms, 41.1% were cognitively impaired, and 41.6% had potentially impaired AF‐related QOL. Participants with low gait speed were significantly more likely to have elevated depressive symptoms (adjusted odds ratio: 2.1, 95% CI: 1.3–3.4), elevated anxiety symptoms (adjusted odds ratio: 2.2, 95% CI: 1.2–3.9), and cognitive impairment (adjusted odds ratio: 1.5, 95% CI: 1.1–2.1). Impaired AF‐related QOL did not differ by gait speed after adjustment for clinical characteristics (adjusted odds ratio: 1.1, 95% CI: 0.8–1.5). Conclusions Twenty‐six percent of older adults with AF had low gait speed, and low gait speed was associated with impaired mood and cognition. Further research is needed to determine whether declines in gait speed lead to impaired mood and cognition or whether these conditions develop concurrently. |
| first_indexed | 2024-12-23T04:53:21Z |
| format | Article |
| id | doaj.art-de16c374d73e48e1978dce36bee414de |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-12-23T04:53:21Z |
| publishDate | 2019-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-de16c374d73e48e1978dce36bee414de2022-12-21T17:59:24ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802019-11-0182210.1161/JAHA.119.013212Gait Speed and Mood, Cognition, and Quality of Life in Older Adults With Atrial FibrillationFrancesca R. Marino0Darleen M. Lessard1Jane S. Saczynski2David D. McManus3Luke G. Silverman‐Lloyd4Christopher M. Benson5Michael J. Blaha6Molly E. Waring7Division of Cardiology Department of Medicine University of Massachusetts Medical School Worcester MADepartment of Population and Quantitative Health Sciences University of Massachusetts Medical School Worcester MADepartment of Pharmacy and Health System Sciences Northeastern University Boston MADivision of Cardiology Department of Medicine University of Massachusetts Medical School Worcester MAUniversity of California, Berkeley – University of California, San Francisco Joint Medical Program UC Berkeley School of Public Health Berkeley CASchool of Medicine Albany Medical College Albany NYCiccarone Center for the Prevention of Cardiovascular Disease Johns Hopkins School of Medicine Baltimore MDDepartment of Allied Health Sciences University of Connecticut Storrs CTBackground Low gait speed has been linked with impaired mood, cognition, and quality of life (QOL) in older adults. We examined whether low gait speed was associated with impaired mood, cognition, and QOL among older adults with atrial fibrillation (AF). Methods and Results Participants (n=1185) had a diagnosis of AF, aged ≥65 years, CHA2DS2VASc ≥2 and had no contraindications to anticoagulation. Participants completed a 15‐foot walk test, and low gait speed was categorized using cutoffs from the Fried Frailty Index. Participants self‐reported measures of depressive symptoms (Patient Health Questionnaire 9 ≥10), anxiety symptoms (Generalized Anxiety Disorder 7 ≥10), cognitive impairment (Montreal Cognitive Assessment ≤23), and potentially impaired Atrial Fibrillation Effect Quality‐of‐Life Questionnaire <80. Participants were on average aged 75.3 (SD: 7.0) years, 48.0% were women, and 85.5% were non‐Hispanic white; 85.6% were taking an oral anticoagulant, 26.1% had low gait speed, 8.4% had elevated depressive symptoms, 5.7% had elevated anxiety symptoms, 41.1% were cognitively impaired, and 41.6% had potentially impaired AF‐related QOL. Participants with low gait speed were significantly more likely to have elevated depressive symptoms (adjusted odds ratio: 2.1, 95% CI: 1.3–3.4), elevated anxiety symptoms (adjusted odds ratio: 2.2, 95% CI: 1.2–3.9), and cognitive impairment (adjusted odds ratio: 1.5, 95% CI: 1.1–2.1). Impaired AF‐related QOL did not differ by gait speed after adjustment for clinical characteristics (adjusted odds ratio: 1.1, 95% CI: 0.8–1.5). Conclusions Twenty‐six percent of older adults with AF had low gait speed, and low gait speed was associated with impaired mood and cognition. Further research is needed to determine whether declines in gait speed lead to impaired mood and cognition or whether these conditions develop concurrently.https://www.ahajournals.org/doi/10.1161/JAHA.119.013212anxietyatrial fibrillationcognitiondepressionquality of life |
| spellingShingle | Francesca R. Marino Darleen M. Lessard Jane S. Saczynski David D. McManus Luke G. Silverman‐Lloyd Christopher M. Benson Michael J. Blaha Molly E. Waring Gait Speed and Mood, Cognition, and Quality of Life in Older Adults With Atrial Fibrillation Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease anxiety atrial fibrillation cognition depression quality of life |
| title | Gait Speed and Mood, Cognition, and Quality of Life in Older Adults With Atrial Fibrillation |
| title_full | Gait Speed and Mood, Cognition, and Quality of Life in Older Adults With Atrial Fibrillation |
| title_fullStr | Gait Speed and Mood, Cognition, and Quality of Life in Older Adults With Atrial Fibrillation |
| title_full_unstemmed | Gait Speed and Mood, Cognition, and Quality of Life in Older Adults With Atrial Fibrillation |
| title_short | Gait Speed and Mood, Cognition, and Quality of Life in Older Adults With Atrial Fibrillation |
| title_sort | gait speed and mood cognition and quality of life in older adults with atrial fibrillation |
| topic | anxiety atrial fibrillation cognition depression quality of life |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.119.013212 |
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