Investigation and Comparison of Coplanar Versus Noncoplanar Intensity-Modulated Radiation Therapy (IMRT) Techniques in Glioblastoma Multiforme Tumors
Background: This study aimed to make a comparison among 4 coplanar and noncoplanar intensity-modulated radiation therapy (IMRT) techniques in glioblastoma multiforme (GBM) tumors, to achieve an optimal treatment technique considering the absorbed doses of organs at risk. Methods: Treatment planning...
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| Format: | Article |
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Isfahan University of Medical Sciences
2018-07-01
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| Series: | مجله دانشکده پزشکی اصفهان |
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| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/9947 |
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| author | Roya Parhizkar-Kalnadani Keyvan Jabbari Seyyed Rabie Mahdavi Golbarg Esmaili |
| author_facet | Roya Parhizkar-Kalnadani Keyvan Jabbari Seyyed Rabie Mahdavi Golbarg Esmaili |
| author_sort | Roya Parhizkar-Kalnadani |
| collection | DOAJ |
| description | Background: This study aimed to make a comparison among 4 coplanar and noncoplanar intensity-modulated radiation therapy (IMRT) techniques in glioblastoma multiforme (GBM) tumors, to achieve an optimal treatment technique considering the absorbed doses of organs at risk.
Methods: Treatment planning and contouring were performed on 20 patients with glioblastoma multiforme tumors in 2 phases based on Radiation Therapy Oncology Group (RTOG) protocol. Four coplanar and noncoplanar intensity-modulated radiation therapy techniques at 6 and 15 MV energy levels were compared. Finally, comparing the conformity and homogeneity indices, and maximum and mean doses (using dose volume histogram), the optimal treatment technique was proposed.
Findings: The absorbed doses of critical organs in the cases of noncoplanar techniques reduced drastically compared with the cases of coplanar techniques. Increase in energy levels in noncoplanar techniques did not impose any significant changes.
Conclusion: The absorbed doses of all critical organs in noncoplanar technique with 6 MV energy level reduced significantly. Besides, in this technique, there was no neutron contamination, because of the employment of 6 MV energy. |
| first_indexed | 2024-03-12T09:51:43Z |
| format | Article |
| id | doaj.art-de17bf8470ba4affad5076b25079bf65 |
| institution | Directory Open Access Journal |
| issn | 1027-7595 1735-854X |
| language | fas |
| last_indexed | 2024-03-12T09:51:43Z |
| publishDate | 2018-07-01 |
| publisher | Isfahan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشکده پزشکی اصفهان |
| spelling | doaj.art-de17bf8470ba4affad5076b25079bf652023-09-02T12:31:57ZfasIsfahan University of Medical Sciencesمجله دانشکده پزشکی اصفهان1027-75951735-854X2018-07-013647847848410.22122/jims.v36i478.99472977Investigation and Comparison of Coplanar Versus Noncoplanar Intensity-Modulated Radiation Therapy (IMRT) Techniques in Glioblastoma Multiforme TumorsRoya Parhizkar-Kalnadani0Keyvan Jabbari1Seyyed Rabie Mahdavi2Golbarg Esmaili3MSc Student, Department of Medical Physics and Engineering, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranAssociate Professor, Department of Medical Physics and Engineering, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranAssociate Professor, Department of Medical Physics and Engineering, School of Medicine, Iran University of Medical Sciences, Tehran, IranPhD, Department of Medical Physics, School of Medicine, Iran University of Medical Sciences, Tehran, IranBackground: This study aimed to make a comparison among 4 coplanar and noncoplanar intensity-modulated radiation therapy (IMRT) techniques in glioblastoma multiforme (GBM) tumors, to achieve an optimal treatment technique considering the absorbed doses of organs at risk. Methods: Treatment planning and contouring were performed on 20 patients with glioblastoma multiforme tumors in 2 phases based on Radiation Therapy Oncology Group (RTOG) protocol. Four coplanar and noncoplanar intensity-modulated radiation therapy techniques at 6 and 15 MV energy levels were compared. Finally, comparing the conformity and homogeneity indices, and maximum and mean doses (using dose volume histogram), the optimal treatment technique was proposed. Findings: The absorbed doses of critical organs in the cases of noncoplanar techniques reduced drastically compared with the cases of coplanar techniques. Increase in energy levels in noncoplanar techniques did not impose any significant changes. Conclusion: The absorbed doses of all critical organs in noncoplanar technique with 6 MV energy level reduced significantly. Besides, in this technique, there was no neutron contamination, because of the employment of 6 MV energy.http://jims.mui.ac.ir/index.php/jims/article/view/9947Treatment protocolsGlioblastoma multiformeRadiation therapy |
| spellingShingle | Roya Parhizkar-Kalnadani Keyvan Jabbari Seyyed Rabie Mahdavi Golbarg Esmaili Investigation and Comparison of Coplanar Versus Noncoplanar Intensity-Modulated Radiation Therapy (IMRT) Techniques in Glioblastoma Multiforme Tumors مجله دانشکده پزشکی اصفهان Treatment protocols Glioblastoma multiforme Radiation therapy |
| title | Investigation and Comparison of Coplanar Versus Noncoplanar Intensity-Modulated Radiation Therapy (IMRT) Techniques in Glioblastoma Multiforme Tumors |
| title_full | Investigation and Comparison of Coplanar Versus Noncoplanar Intensity-Modulated Radiation Therapy (IMRT) Techniques in Glioblastoma Multiforme Tumors |
| title_fullStr | Investigation and Comparison of Coplanar Versus Noncoplanar Intensity-Modulated Radiation Therapy (IMRT) Techniques in Glioblastoma Multiforme Tumors |
| title_full_unstemmed | Investigation and Comparison of Coplanar Versus Noncoplanar Intensity-Modulated Radiation Therapy (IMRT) Techniques in Glioblastoma Multiforme Tumors |
| title_short | Investigation and Comparison of Coplanar Versus Noncoplanar Intensity-Modulated Radiation Therapy (IMRT) Techniques in Glioblastoma Multiforme Tumors |
| title_sort | investigation and comparison of coplanar versus noncoplanar intensity modulated radiation therapy imrt techniques in glioblastoma multiforme tumors |
| topic | Treatment protocols Glioblastoma multiforme Radiation therapy |
| url | http://jims.mui.ac.ir/index.php/jims/article/view/9947 |
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