HI A ASSOCIATION WITH CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA
Summary: OBJECTIVE Many associations have been found between specific HLA antigens and increased susceptibility to various diseases . So we tried to associate class I and class II antigens with acute lymphoblastic leukemia . We also demonstrate the presence of antibodies in serum of acute lymphoblas...
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| Format: | Article |
| Language: | English |
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College of Medicine University of Baghdad
2005-07-01
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| Series: | مجلة كلية الطب |
| Subjects: | |
| Online Access: | http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/1647 |
| _version_ | 1797370109395730432 |
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| author | BATOOL M. MAHDI salalwa M. Shareef |
| author_facet | BATOOL M. MAHDI salalwa M. Shareef |
| author_sort | BATOOL M. MAHDI |
| collection | DOAJ |
| description | Summary:
OBJECTIVE Many associations have been found between specific HLA antigens and increased susceptibility to various diseases . So we tried to associate class I and class II antigens with acute lymphoblastic leukemia . We also demonstrate the presence of antibodies in serum of acute lymphoblastic leukemic patients against HLA class I.
DESIGN: Prospective study.
SETTING: Tissue typing and histocompatibility center at Al- Karamah Teaching Hospital. PATIENTS AND METHOD: 70 acute lymphoblastic leukemia patients from pediatric hospitals. HLA ( human leukocyte antigens) typing done for them by serological method and cross matching and blood grouping were also done for them.
RESULTS: there was significant difference between patients and control groups regarding HLA -C6.DR1, DR4, DR7, DQ1.DQ2 ,DQ3, DQ4. There was 14.2 % (10/70) of patients had antibodies against HLA class I. There was no significant association between blood group and acute lymphoblastic leukemia .
CONCLUSION: Genetic factor increased susceptibility with acute lymphoblastic leukemia ( HLA- DR1 DQ1, HLA - DR4 DQ4, HLA- DR4 DQ3, HLA- DR7 DQ2. This HLA typing increased susceptibility to be affected with leukemia after infection.
RECOMMEND A TION: HLA typing was done to acute lymphoblastic leukemic patients by molecular -DNA based method (PCR-SSP, RSCA) in addition to serological method. |
| first_indexed | 2024-03-08T17:56:43Z |
| format | Article |
| id | doaj.art-de1ac5ac4fce430e902250518407d12c |
| institution | Directory Open Access Journal |
| issn | 0041-9419 2410-8057 |
| language | English |
| last_indexed | 2024-03-08T17:56:43Z |
| publishDate | 2005-07-01 |
| publisher | College of Medicine University of Baghdad |
| record_format | Article |
| series | مجلة كلية الطب |
| spelling | doaj.art-de1ac5ac4fce430e902250518407d12c2024-01-02T04:42:28ZengCollege of Medicine University of Baghdadمجلة كلية الطب0041-94192410-80572005-07-0147210.32007/1647140-144HI A ASSOCIATION WITH CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIABATOOL M. MAHDI0salalwa M. Shareef1Al-kindi college of medicine Department of microbiology.university of Baghdad, college of medicine.Summary: OBJECTIVE Many associations have been found between specific HLA antigens and increased susceptibility to various diseases . So we tried to associate class I and class II antigens with acute lymphoblastic leukemia . We also demonstrate the presence of antibodies in serum of acute lymphoblastic leukemic patients against HLA class I. DESIGN: Prospective study. SETTING: Tissue typing and histocompatibility center at Al- Karamah Teaching Hospital. PATIENTS AND METHOD: 70 acute lymphoblastic leukemia patients from pediatric hospitals. HLA ( human leukocyte antigens) typing done for them by serological method and cross matching and blood grouping were also done for them. RESULTS: there was significant difference between patients and control groups regarding HLA -C6.DR1, DR4, DR7, DQ1.DQ2 ,DQ3, DQ4. There was 14.2 % (10/70) of patients had antibodies against HLA class I. There was no significant association between blood group and acute lymphoblastic leukemia . CONCLUSION: Genetic factor increased susceptibility with acute lymphoblastic leukemia ( HLA- DR1 DQ1, HLA - DR4 DQ4, HLA- DR4 DQ3, HLA- DR7 DQ2. This HLA typing increased susceptibility to be affected with leukemia after infection. RECOMMEND A TION: HLA typing was done to acute lymphoblastic leukemic patients by molecular -DNA based method (PCR-SSP, RSCA) in addition to serological method.http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/1647ALL, HLA typing, antibodies, blood group. |
| spellingShingle | BATOOL M. MAHDI salalwa M. Shareef HI A ASSOCIATION WITH CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA مجلة كلية الطب ALL, HLA typing, antibodies, blood group. |
| title | HI A ASSOCIATION WITH CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA |
| title_full | HI A ASSOCIATION WITH CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA |
| title_fullStr | HI A ASSOCIATION WITH CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA |
| title_full_unstemmed | HI A ASSOCIATION WITH CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA |
| title_short | HI A ASSOCIATION WITH CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA |
| title_sort | hi a association with childhood acute lymphoblastic leukemia |
| topic | ALL, HLA typing, antibodies, blood group. |
| url | http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/1647 |
| work_keys_str_mv | AT batoolmmahdi hiaassociationwithchildhoodacutelymphoblasticleukemia AT salalwamshareef hiaassociationwithchildhoodacutelymphoblasticleukemia |