Catamenial Epilepsy
When seizures occur in clusters during certain stages of the menstrual cycle (perimenstrual and periovulatory stages), it is defined as catamenial epilepsy. The prevalence varies between 10% and 70%. There are 3 patterns of catamenial epilepsy: perimenstrual (most common), periovulatory, and seizure...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2018-01-01
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| Series: | Archives of Epilepsy |
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| Online Access: |
http://archepilepsy.org/archives/archive-detail/article-preview/catamenial-epilepsy/54919
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| _version_ | 1827888776445165568 |
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| author | Rabia Gökçen GÖZÜBATIK ÇELİK Çiğdem ÖZKARA |
| author_facet | Rabia Gökçen GÖZÜBATIK ÇELİK Çiğdem ÖZKARA |
| author_sort | Rabia Gökçen GÖZÜBATIK ÇELİK |
| collection | DOAJ |
| description | When seizures occur in clusters during certain stages of the menstrual cycle (perimenstrual and periovulatory stages), it is defined as catamenial epilepsy. The prevalence varies between 10% and 70%. There are 3 patterns of catamenial epilepsy: perimenstrual (most common), periovulatory, and seizures in the insufficient luteal phase. In the pathophysiology of this occurrence, the neuroactive properties of the reproduction-associated steroid hormones (direct membrane-associated short-term effect and intracellular receptor/genomic-related longterm effect) and their cyclic changes in serum levels play a role in the susceptibility of the epileptogenic area to neuroactive steroids. Among steroid hormones, while progesterone and neurosteroids are known as anticonvulsants, estrogen, the best known proconvulsant, has been found in recent studies to also have anticonvulsant effects related to Neuropeptide Y. Hormonal (medroxyprogesterone acetate, clomiphene, triptorelin, leuprolide, progesterone, goserelin), non-hormonal (acetazolamide, clobazam, lamotrigine, levetiracetam), and neurosteroidbased therapies (ganaxolone) are used in the treatment of catamenial epilepsy. Seizure control and menstrual cycle maintenance, measurement of the blood level of antiepileptic drugs before and after menstruation and adjustment of the drug dosage as required, intermittent benzodiazepine administration, acetazolamide, or hormonal treatments such as oral contraceptives during menstruation are among the treatment strategies for catamenial epilepsy. |
| first_indexed | 2024-03-12T20:39:36Z |
| format | Article |
| id | doaj.art-de1e5eb0c5fb49a38a5f2cb915f0c799 |
| institution | Directory Open Access Journal |
| issn | 2792-0550 |
| language | English |
| last_indexed | 2024-03-12T20:39:36Z |
| publishDate | 2018-01-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Archives of Epilepsy |
| spelling | doaj.art-de1e5eb0c5fb49a38a5f2cb915f0c7992023-08-01T11:13:34ZengGalenos YayineviArchives of Epilepsy2792-05502018-01-01241304010.14744/epilepsi.2018.2534913049054Catamenial EpilepsyRabia Gökçen GÖZÜBATIK ÇELİK0Çiğdem ÖZKARA1 Bakırköy Prof Dr. Mazhar Osman Ruh Sağlığı ve Sinir Hastalıkları Eğitim Araştırma Hastanesi Nöroloji Bölümü, İstanbul Istanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Nöroloji Anabilim Dalı, İstanbul When seizures occur in clusters during certain stages of the menstrual cycle (perimenstrual and periovulatory stages), it is defined as catamenial epilepsy. The prevalence varies between 10% and 70%. There are 3 patterns of catamenial epilepsy: perimenstrual (most common), periovulatory, and seizures in the insufficient luteal phase. In the pathophysiology of this occurrence, the neuroactive properties of the reproduction-associated steroid hormones (direct membrane-associated short-term effect and intracellular receptor/genomic-related longterm effect) and their cyclic changes in serum levels play a role in the susceptibility of the epileptogenic area to neuroactive steroids. Among steroid hormones, while progesterone and neurosteroids are known as anticonvulsants, estrogen, the best known proconvulsant, has been found in recent studies to also have anticonvulsant effects related to Neuropeptide Y. Hormonal (medroxyprogesterone acetate, clomiphene, triptorelin, leuprolide, progesterone, goserelin), non-hormonal (acetazolamide, clobazam, lamotrigine, levetiracetam), and neurosteroidbased therapies (ganaxolone) are used in the treatment of catamenial epilepsy. Seizure control and menstrual cycle maintenance, measurement of the blood level of antiepileptic drugs before and after menstruation and adjustment of the drug dosage as required, intermittent benzodiazepine administration, acetazolamide, or hormonal treatments such as oral contraceptives during menstruation are among the treatment strategies for catamenial epilepsy. http://archepilepsy.org/archives/archive-detail/article-preview/catamenial-epilepsy/54919 antiepilepticsepilepsymenstrual cycleestrogen; pathophysiologyprogesteronereproductive hormone replacement therapy |
| spellingShingle | Rabia Gökçen GÖZÜBATIK ÇELİK Çiğdem ÖZKARA Catamenial Epilepsy Archives of Epilepsy antiepileptics epilepsy menstrual cycle estrogen; pathophysiology progesterone reproductive hormone replacement therapy |
| title | Catamenial Epilepsy |
| title_full | Catamenial Epilepsy |
| title_fullStr | Catamenial Epilepsy |
| title_full_unstemmed | Catamenial Epilepsy |
| title_short | Catamenial Epilepsy |
| title_sort | catamenial epilepsy |
| topic | antiepileptics epilepsy menstrual cycle estrogen; pathophysiology progesterone reproductive hormone replacement therapy |
| url |
http://archepilepsy.org/archives/archive-detail/article-preview/catamenial-epilepsy/54919
|
| work_keys_str_mv | AT rabiagokcengozubatikcelik catamenialepilepsy AT cigdemozkara catamenialepilepsy |